Search Results - "Kelley, Ann C."

Elongation Factor G Bound to the Ribosome in an Intermediate State of Translocation by Tourigny, David S., Fernández, Israel S., Kelley, Ann C., Ramakrishnan, V.

“…A key step of translation by the ribosome is translocation, which involves the movement of messenger RNA (mRNA) and transfer RNA (tRNA) with respect to the…”
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Mechanism for Activation of GTP Hydrolysis on the Ribosome by Voorhees, Rebecca M, Schmeing, T. Martin, Kelley, Ann C, Ramakrishnan, V

“…Protein synthesis requires several guanosine triphosphatase (GTPase) factors, including elongation factor Tu (EF-Tu), which delivers aminoacyl-transfer RNAs…”
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Crystal structure of the hybrid state of ribosome in complex with the guanosine triphosphatase release factor 3 by Jin, Hong, Kelley, Ann C, Ramakrishnan, V

“…Protein release factor 3 (RF3), a guanosine triphosphatase, binds to ribosome after release of the nascent peptide and promotes dissociation of the class I…”
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Decoding in the Absence of a Codon by tmRNA and SmpB in the Ribosome by Neubauer, Cajetan, Gillet, Reynald, Kelley, Ann C., Ramakrishnan, V.

“…In bacteria, ribosomes stalled at the end of truncated messages are rescued by transfer-messenger RNA (tmRNA), a bifunctional molecule that acts as both a…”
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Crystal Structure of the Ribosome Bound to EF-Tu and Aminoacyl-tRNA by Schmeing, T. Martin, Voorhees, Rebecca M, Kelley, Ann C, Gao, Yong-Gui, Murphy, Frank V. IV, Weir, John R, Ramakrishnan, V

“…The ribosome selects a correct transfer RNA (tRNA) for each amino acid added to the polypeptide chain, as directed by messenger RNA. Aminoacyl-tRNA is…”
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Molecular Architecture of a Eukaryotic Translational Initiation Complex by Fernández, Israel S., Bai, Xiao-Chen, Hussain, Tanweer, Kelley, Ann C., Lorsch, Jon R., Ramakrishnan, V., Scheres, Sjors H. W.

“…The last step in eukaryotic translational initiation involves the joining of the large and small subunits of the ribosome, with initiator transfer RNA…”
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How mutations in tRNA distant from the anticodon affect the fidelity of decoding by Schmeing, T Martin, Voorhees, Rebecca M, Kelley, Ann C, Ramakrishnan, V

“…It has long been known that mutations in the body of the tRNA can affect translational fidelity, but how? The crystal structures of the 70S ribosome complexed…”
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The Structural Basis for mRNA Recognition and Cleavage by the Ribosome-Dependent Endonuclease RelE by Neubauer, Cajetan, Gao, Yong-Gui, Andersen, Kasper R., Dunham, Christine M., Kelley, Ann C., Hentschel, Jendrik, Gerdes, Kenn, Ramakrishnan, V., Brodersen, Ditlev E.

“…Translational control is widely used to adjust gene expression levels. During the stringent response in bacteria, mRNA is degraded on the ribosome by the…”
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Structure of the 70S ribosome bound to release factor 2 and a substrate analog provides insights into catalysis of peptide release by Jin, Hong, Kelley, Ann C, Loakes, David, Ramakrishnan, V

“…We report the crystal structure of release factor 2 bound to ribosome with an aminoacyl tRNA substrate analog at the ribosomal P site, at 3.1 Å resolution. The…”
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GTPase activation of elongation factor EF-Tu by the ribosome during decoding by Schuette, Jan-Christian, Murphy IV, Frank V, Kelley, Ann C, Weir, John R, Giesebrecht, Jan, Connell, Sean R, Loerke, Justus, Mielke, Thorsten, Zhang, Wei, Penczek, Pawel A, Ramakrishnan, V, Spahn, Christian M T

“…We have used single‐particle reconstruction in cryo‐electron microscopy to determine a structure of the Thermus thermophilus ribosome in which the ternary…”
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The ribosome triggers the stringent response by RelA via a highly distorted tRNA by Agirrezabala, Xabier, Fernández, Israel S, Kelley, Ann C, Cartón, David Gil, Ramakrishnan, Venki, Valle, Mikel

“…The bacterial stringent response links nutrient starvation with the transcriptional control of genes. This process is initiated by the stringent factor RelA,…”
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Modification of 16S ribosomal RNA by the KsgA methyltransferase restructures the 30S subunit to optimize ribosome function by Demirci, Hasan, Murphy, 4th, Frank, Belardinelli, Riccardo, Kelley, Ann C, Ramakrishnan, V, Gregory, Steven T, Dahlberg, Albert E, Jogl, Gerwald

“…All organisms incorporate post-transcriptional modifications into ribosomal RNA, influencing ribosome assembly and function in ways that are poorly understood…”
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Crystal structure of the ribosome recycling factor bound to the ribosome by Ramakrishnan, V, Dunham, Christine M, Kelley, Ann C, Weixlbaumer, Albert, Petry, Sabine, Selmer, Maria

“…In bacteria, disassembly of the ribosome at the end of translation is facilitated by an essential protein factor termed ribosome recycling factor (RRF), which…”
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Crystal Structure of a Bioactive Pactamycin Analog Bound to the 30S Ribosomal Subunit by Tourigny, David S., Fernández, Israel S., Kelley, Ann C., Vakiti, Ramkrishna Reddy, Chattopadhyay, Amit Kumar, Dorich, Stéphane, Hanessian, Stephen, Ramakrishnan, V.

“…Biosynthetically and chemically derived analogs of the antibiotic pactamycin and de-6-methylsalicylyl (MSA)-pactamycin have attracted recent interest as…”
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Response to Comment on “The Mechanism for Activation of GTP Hydrolysis on the Ribosome” by Voorhees, Rebecca M., Schmeing, T. Martin, Kelley, Ann C., Ramakrishnan, V.

“…Our report of the crystal structure of elongation factor Tu (EF-Tu) and aminoacyl–transfer RNA bound to the ribosome with a guanosine triphosphate (GTP) analog…”
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Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome by Kelley, Ann C, Voorhees, Rebecca M, Weixlbaumer, Albert, Ramakrishnan, V, Loakes, David

“…Protein synthesis is catalyzed in the peptidyl transferase center of the ribosome. The structure of the 70S ribosome containing tRNAs now gives insight into…”
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Unusual base pairing during the decoding of a stop codon by the ribosome by Fernández, Israel S., Ng, Chyan Leong, Kelley, Ann C., Wu, Guowei, Yu, Yi-Tao, Ramakrishnan, V.

“…Here, the structure of the 30S ribosomal subunit and the 70S ribosome in complex with a messenger RNA with pseudouridine in the place of uridine reveals…”
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Insights into Translational Termination from the Structure of RF2 Bound to the Ribosome by Weixlbaumer, Albert, Jin, Hong, Neubauer, Cajetan, Voorhees, Rebecca M, Petry, Sabine, Kelley, Ann C, Ramakrishnan, Venki

“…The termination of protein synthesis occurs through the specific recognition of a stop codon in the A site of the ribosome by a release factor (RF), which then…”
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Structure of the Ribosome with Elongation Factor G Trapped in the Posttranslocational State by Gao, Yong-Gui, Selmer, Maria, Dunham, Christine M, Weixlbaumer, Albert, Kelley, Ann C, Ramakrishnan, V

“…Elongation factor G (EF-G) is a guanosine triphosphatase (GTPase) that plays a crucial role in the translocation of transfer RNAs (tRNAs) and messenger RNA…”
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Structure of the 70S Ribosome Complexed with mRNA and tRNA by Selmer, Maria, Dunham, Christine M, Murphy, Frank V. IV, Weixlbaumer, Albert, Petry, Sabine, Kelley, Ann C, Weir, John R, Ramakrishnan, V

“…The crystal structure of the bacterial 70S ribosome refined to 2.8 angstrom resolution reveals atomic details of its interactions with messenger RNA (mRNA) and…”
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