Search Results - "Kellett, Andrew"

Molecular methods for assessment of non-covalent metallodrug-DNA interactions by Kellett, Andrew, Molphy, Zara, Slator, Creina, McKee, Vickie, Farrell, Nicholas P

“…The binding of small molecule metallodrugs to discrete regions of nucleic acids is an important branch of medicinal chemistry and the nature of these…”
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Two‐Photon Polymerization: Fundamentals, Materials, and Chemical Modification Strategies by O'Halloran, Seán, Pandit, Abhay, Heise, Andreas, Kellett, Andrew

“…Two‐photon polymerization (TPP) has become a premier state‐of‐the‐art method for microscale fabrication of bespoke polymeric devices and surfaces. With…”
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A phosphate-targeted dinuclear Cu(II) complex combining major groove binding and oxidative DNA cleavage by Molphy, Zara, Montagner, Diego, Bhat, Satish S, Slator, Creina, Long, Conor, Erxleben, Andrea, Kellett, Andrew

“…Abstract Free radical generation is an inevitable consequence of aerobic existence and is implicated in a wide variety of pathological conditions including…”
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Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors by Banasiak, Anna, Zuin Fantoni, Nicolò, Kellett, Andrew, Colleran, John

“…Several classes of copper complexes are known to induce oxidative DNA damage that mediates cell death. These compounds are potentially useful anticancer agents…”
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Triggering autophagic cell death with a di-manganese(II) developmental therapeutic by Slator, Creina, Molphy, Zara, McKee, Vickie, Kellett, Andrew

“…There is an unmet need for novel metal-based chemotherapeutics with alternative modes of action compared to clinical agents such as cisplatin and…”
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Anticancer activity, DNA binding and cell mechanistic studies of estrogen-functionalised Cu(II) complexes by Barrett, Stephen, De Franco, Michele, Kellett, Andrew, Dempsey, Eithne, Marzano, Cristina, Erxleben, Andrea, Gandin, Valentina, Montagner, Diego

“…Four estrogen-functionalised copper complexes were synthesised and investigated as electrochemical active DNA binding and cleavage agents. These complexes…”
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The phosphate clamp: sequence selective nucleic acid binding profiles and conformational induction of endonuclease inhibition by cationic Triplatin complexes by Prisecaru, Andreea, Molphy, Zara, Kipping, Ralph G, Peterson, Erica J, Qu, Yun, Kellett, Andrew, Farrell, Nicholas P

“…The substitution-inert polynuclear platinum(II) complex (PPC) series, [{trans-Pt(NH3)2(NH2(CH2)nNH3)}2-μ-(trans-Pt(NH3)2(NH2(CH2)nNH2)2}](NO3)8, where n = 5…”
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Radical-induced DNA damage by cytotoxic square-planar copper(II) complexes incorporating o-phthalate and 1,10-phenanthroline or 2,2′-dipyridyl by Kellett, Andrew, Howe, Orla, O'Connor, Mark, McCann, Malachy, Creaven, Bernadette S., McClean, Siobhán, Foltyn-Arfa Kia, Agnieszka, Casey, Alan, Devereux, Michael

“…DNA-targeting copper(II) reagents have emerged as suitable drug candidates owing to the clinical success of the copper-activated, natural chemotherapeutic drug…”
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Process-relevant concentrations of the leachable bDtBPP impact negatively on CHO cell production characteristics by Kelly, Paul S., McSweeney, Shane, Coleman, Orla, Carillo, Sara, Henry, Michael, Chandran, Deepak, Kellett, Andrew, Bones, Jonathan, Clynes, Martin, Meleady, Paula, Barron, Niall

“…The biopharmaceutical industry has invested considerably in the implementation of single‐use disposable bioreactors in place of or in addition to their…”
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Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity by McCann, Malachy, Curran, Robert, Ben-Shoshan, Marcia, McKee, Vickie, Tahir, Asif Ali, Devereux, Michael, Kavanagh, Kevin, Creaven, Bernadette S, Kellett, Andrew

“…[Ag(2)(9-aca)(2)] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)(2.3)(CH(3)CN)(0.7)](9-aca) (3),…”
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Assessment of DNA Topoisomerase I Unwinding Activity, Radical Scavenging Capacity, and Inhibition of Breast Cancer Cell Viability of N -alkyl-acridones and N , N' -dialkyl-9,9'-biacridylidenes by Krokidis, Marios G, Molphy, Zara, Efthimiadou, Eleni K, Kokoli, Marianna, Argyri, Smaragda-Maria, Dousi, Irini, Masi, Annalisa, Papadopoulos, Kyriakos, Kellett, Andrew, Chatgilialoglu, Chryssostomos

“…The anticancer activity of acridone derivatives has attracted increasing interest, therefore, a variety of substituted analogs belonging to this family have…”
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[Cu(TPMA)(Phen)](ClO4)2: Metallodrug Nanocontainer Delivery and Membrane Lipidomics of a Neuroblastoma Cell Line Coupled with a Liposome Biomimetic Model Focusing on Fatty Acid Reactivity by Toniolo, Gianluca, Louka, Maria, Menounou, Georgia, Fantoni, Nicolò Zuin, Mitrikas, George, Efthimiadou, Eleni K, Masi, Annalisa, Bortolotti, Massimo, Polito, Letizia, Bolognesi, Andrea, Kellett, Andrew, Ferreri, Carla, Chatgilialoglu, Chryssostomos

“…The use of copper complexes for redox and oxidative-based mechanisms in therapeutic strategies is an important field of multidisciplinary research. Here, a…”
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Gene Editing with Artificial DNA Scissors by Gibney, Alex, Kellett, Andrew

“…Artificial metallo‐nucleases (AMNs) are small molecule DNA cleavage agents, also known as DNA molecular scissors, and represent an important class of…”
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Australian integrative oncology services: a mixed-method study exploring the views of cancer survivors by Hunter, Jennifer, Ussher, Jane, Parton, Chloe, Kellett, Andrew, Smith, Caroline, Delaney, Geoff, Oyston, Eleanor

“…The significant use of traditional and complementary medicine (T&CM) by cancer survivors is well documented. The aim of this study was to explore cancer…”
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Third‐Generation Sequencing of Epigenetic DNA by Searle, Bethany, Müller, Markus, Carell, Thomas, Kellett, Andrew

“…The discovery of epigenetic bases has revolutionised the understanding of disease and development. Among the most studied epigenetic marks are cytosines…”
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Copper bis -Dipyridoquinoxaline Is a Potent DNA Intercalator that Induces Superoxide-Mediated Cleavage via the Minor Groove by Molphy, Zara, McKee, Vickie, Kellett, Andrew

“…Herein, we report the synthesis, characterisation, X-ray crystallography, and oxidative DNA binding interactions of the copper artificial metallo-nuclease…”
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Di-copper metallodrugs promote NCI-60 chemotherapy via singlet oxygen and superoxide production with tandem TA/TA and AT/AT oligonucleotide discrimination by Slator, Creina, Molphy, Zara, McKee, Vickie, Long, Conor, Brown, Tom, Kellett, Andrew

“…Abstract In order to expand the current repertoire of cancer treatments and to help circumvent limitations associated with resistance, the identification of…”
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Analysis of non-canonical three- and four-way DNA junctions by McGorman, Bríonna, Poole, Simon, López, Miguel Vázquez, Kellett, Andrew

“…[Display omitted] •Multiplex fluorescent polyacrylamide gel electrophoresis (PAGE) for the visualisation of three- and four-way DNA junctions.•Microscale…”
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Click and Cut: a click chemistry approach to developing oxidative DNA damaging agents by McStay, Natasha, Slator, Creina, Singh, Vandana, Gibney, Alex, Westerlund, Fredrik, Kellett, Andrew

“…Metallodrugs provide important first-line treatment against various forms of human cancer. To overcome chemotherapeutic resistance and widen treatment…”
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DNA‐Targeted Metallodrugs: An Untapped Source of Artificial Gene Editing Technology by Fantoni, Nicolò Zuin, Brown, Tom, Kellett, Andrew

“…DNA binding metal complexes are synonymous with anticancer drug discovery. Given the array of structural and chemical reactivity properties available through…”
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