Search Results - "Keller, Patrick W"
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Effect of Thrombin on Human Amnion Mesenchymal Cells, Mouse Fetal Membranes, and Preterm Birth
Published in The Journal of biological chemistry (09-05-2014)“…Here, we investigated the effects of thrombin on matrix metalloproteinases (MMPs) and prostaglandin (PG) synthesis in fetal membranes. Thrombin activity was…”
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Fetal Fibronectin Signaling Induces Matrix Metalloproteases and Cyclooxygenase-2 (COX-2) in Amnion Cells and Preterm Birth in Mice
Published in The Journal of biological chemistry (18-01-2013)“…Fetal fibronectin (fFN) in cervical and vaginal secretions has been used as a predictor of preterm delivery. Here, we clarified the pathological function of…”
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3
Dysregulation of fibulin-5 and matrix metalloproteases in epithelial ovarian cancer
Published in Oncotarget (06-03-2018)“…Fibulin 5 (FBLN5) is an extracellular matrix glycoprotein that suppresses matrix metalloprotease 9 (MMP-9), angiogenesis and epithelial cell motility. Here, we…”
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Failure of Pelvic Organ Support in Mice Deficient In Fibulin-3
Published in The American journal of pathology (2009)“…Fibulin-5 is crucial for normal elastic fiber synthesis in the vaginal wall; more than 90% of fibulin-5-knockout mice develop pelvic organ prolapse by 20 weeks…”
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Effect of Myogenic Stem Cells on Contractile Properties of the Repaired and Unrepaired Transected External Anal Sphincter in an Animal Model
Published in Obstetrics and gynecology (New York. 1953) (01-04-2010)“…To estimate the effect of myogenic stem cells on contractile function of the external anal sphincter after transection with or without repair in an animal…”
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Journal Article Conference Proceeding -
6
Neuraminidase-1 is required for the normal assembly of elastic fibers
Published in American journal of physiology. Lung cellular and molecular physiology (01-10-2008)“…The assembly of elastic fibers in tissues that undergo repeated cycles of extension and recoil, such as the lungs and blood vessels, is dependent on the proper…”
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Regulation of Elastolytic Proteases in the Mouse Vagina During Pregnancy, Parturition, and Puerperium
Published in Biology of reproduction (01-03-2008)“…Recent evidence indicates that failure of elastic fiber assembly and synthesis is involved in the pathophysiology of pelvic organ prolapse in mice. It has been…”
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Vaginal estrogen: a dual-edged sword in postoperative healing of the vaginal wall
Published in Menopause (New York, N.Y.) (01-07-2017)“…OBJECTIVE:Reconstructive surgery for pelvic organ prolapse is plagued with high failure rates possibly due to impaired healing or regeneration of the vaginal…”
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Androgens Upregulate Endometrial Epithelial Progesterone Receptor Expression: Potential Implications for Endometriosis
Published in Reproductive sciences (Thousand Oaks, Calif.) (01-10-2017)“…Androgenic compounds have been implicated in induction of endometrial atrophy yet the mechanisms of androgen effects on human endometrium have not been well…”
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Effects of vaginal conjugated equine estrogens and ospemifene on the rat vaginal wall and lower urinary tract
Published in Biology of reproduction (01-01-2017)“…Although the positive effects of vaginal estrogens and the selective estrogen receptor modulator, ospemifene (OS), on the vaginal epithelium are well…”
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Regulation of Elastolytic Proteases in the Mouse Vagina During Pregnancy, Parturition, and Puerperium1
Published in Biology of reproduction (01-03-2008)“…Recent evidence indicates that failure of elastic fiber assembly and synthesis is involved in the pathophysiology of pelvic organ prolapse in mice. It has been…”
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12
Estrogen Alters Remodeling of the Vaginal Wall after Surgical Injury in Guinea Pigs
Published in Biology of reproduction (01-12-2013)“…Loss of pelvic organ support (i.e., pelvic organ prolapse) is common in menopausal women. Surgical reconstruction of pelvic organ prolapse is plagued with high…”
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13
Myogenic stem cell-laden hydrogel scaffold in wound healing of the disrupted external anal sphincter
Published in International Urogynecology Journal (01-06-2015)“…Objective To evaluate the effect of myogenic stem cell-laden hydrogel scaffold on contractile function and histomorphology of the external anal sphincter (EAS)…”
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Recovery of the Injured External Anal Sphincter After Injection of Local or Intravenous Mesenchymal Stem Cells
Published in Obstetrics and gynecology (New York. 1953) (01-01-2012)“…OBJECTIVES:To understand the endogenous process of wound healing after anal sphincter injury and to determine possible mechanisms by which mesenchymal stem…”
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Journal Article Conference Proceeding -
15
Estrogen Alters Remodeling of the Vaginal Wall after Surgical Injury in Guinea Pigs1
Published in Biology of reproduction (01-12-2013)“…Loss of pelvic organ support (i.e., pelvic organ prolapse) is common in menopausal women. Surgical reconstruction of pelvic organ prolapse is plagued with high…”
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Journal Article