Search Results - "Keller, Kate E"

Pathogenesis of glaucoma: Extracellular matrix dysfunction in the trabecular meshwork‐A review by Keller, Kate E., Peters, Donna M.

“…The trabecular meshwork regulates aqueous humour outflow from the anterior chamber of the eye. It does this by establishing a tunable outflow resistance,…”
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Extracellular matrix in the trabecular meshwork: Intraocular pressure regulation and dysregulation in glaucoma by Vranka, Janice A., Kelley, Mary J., Acott, Ted S., Keller, Kate E.

“…The trabecular meshwork (TM) is located in the anterior segment of the eye and is responsible for regulating the outflow of aqueous humor. Increased resistance…”
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Consensus recommendations for trabecular meshwork cell isolation, characterization and culture by Keller, Kate E., Bhattacharya, Sanjoy K., Borrás, Theresa, Brunner, Thomas M., Chansangpetch, Sunee, Clark, Abbott F., Dismuke, W. Michael, Du, Yiqin, Elliott, Michael H., Ethier, C. Ross, Faralli, Jennifer A., Freddo, Thomas F., Fuchshofer, Rudolf, Giovingo, Michael, Gong, Haiyan, Gonzalez, Pedro, Huang, Alex, Johnstone, Murray A., Kaufman, Paul L., Kelley, Mary J., Knepper, Paul A., Kopczynski, Casey C., Kuchtey, John G., Kuchtey, Rachel W., Kuehn, Markus H., Lieberman, Raquel L., Lin, Shan C., Liton, Paloma, Liu, Yutao, Lütjen-Drecoll, Elke, Mao, Weiming, Masis-Solano, Marisse, McDonnell, Fiona, McDowell, Colleen M., Overby, Darryl R., Pattabiraman, Padmanabhan P., Raghunathan, Vijay K., Rao, P. Vasanth, Rhee, Douglas J., Chowdhury, Uttio Roy, Russell, Paul, Samples, John R., Schwartz, Donald, Stubbs, Evan B., Tamm, Ernst R., Tan, James C., Toris, Carol B., Torrejon, Karen Y., Vranka, Janice A., Wirtz, Mary K., Yorio, Thomas, Zhang, Jie, Zode, Gulab S., Fautsch, Michael P., Peters, Donna M., Acott, Ted S., Stamer, W. Daniel

“…Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow…”
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Digital spatial profiling of segmental outflow regions in trabecular meshwork reveals a role for ADAM15 by Faralli, Jennifer A, Filla, Mark S, Yang, Yong-Feng, Sun, Ying Ying, Johns, Kassidy, Keller, Kate E, Peters, Donna M

“…In this study we used a spatial transcriptomics approach to identify genes specifically associated with either high or low outflow regions in the trabecular…”
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Mapping molecular differences and extracellular matrix gene expression in segmental outflow pathways of the human ocular trabecular meshwork by Vranka, Janice A, Bradley, John M, Yang, Yong-Feng, Keller, Kate E, Acott, Ted S

“…Elevated intraocular pressure (IOP) is the primary risk factor for glaucoma, and lowering IOP remains the only effective treatment for glaucoma. The trabecular…”
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Tunneling nanotubes and actin cytoskeleton dynamics in glaucoma by Keller, Kate

“…A similar phalloidin-stained, TNT-like structure was found in TM tissue [Figure 1]A3. [...]TNTs can provide a direct and specific mode of cellular…”
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The Role of the IL-20 Subfamily in Glaucoma by Wirtz, Mary K., Keller, Kate E.

“…Glaucoma is a common disease that leads to loss of peripheral vision and, if left untreated, ultimately to blindness. While the exact cause(s) of glaucoma is…”
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Inhibition of hyaluronan synthesis reduces versican and fibronectin levels in trabecular meshwork cells by Keller, Kate E, Sun, Ying Ying, Vranka, Janice A, Hayashi, Lauren, Acott, Ted S

“…Hyaluronan (HA) is a major component of the extracellular matrix (ECM) and is synthesized by three HA synthases (HAS). Similarities between the HAS2 knockout…”
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Extracellular Matrix Gene Alternative Splicing by Trabecular Meshwork Cells in Response to Mechanical Stretching by Keller, Kate E, Kelley, Mary J, Acott, Ted S

“…Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In…”
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The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells by Yang, Yong-Feng, Sun, Ying Ying, Peters, Donna M, Keller, Kate E

“…The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular…”
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Specialized Podosome- or Invadopodia-like Structures (PILS) for Focal Trabecular Meshwork Extracellular Matrix Turnover by Aga, Mini, Bradley, John M, Keller, Kate E, Kelley, Mary J, Acott, Ted S

“…There are distinctive areas of colocalization of matrix metalloproteinase (MMP)-2 and -14 on trabecular meshwork (TM) cells that resemble podosomes or…”
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Normal and glaucomatous outflow regulation by Acott, Ted S., Vranka, Janice A., Keller, Kate E., Raghunathan, VijayKrishna, Kelley, Mary J.

“…Glaucoma remains only partially understood, particularly at the level of intraocular pressure (IOP) regulation. Trabecular meshwork (TM) and Schlemm's canal…”
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Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma by Keller, Kate E, Yang, Yong-Feng, Sun, Ying Ying, Sykes, Renee, Gaudette, Natalie Donna, Samples, John R, Acott, Ted S, Wirtz, Mary K

“…To determine whether interleukin-20 receptors (IL-20R) are expressed in trabecular meshwork cells and the effect of a T104M mutation in IL-20R2 on downstream…”
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Phenotypic and Functional Alterations in Tunneling Nanotubes Formed by Glaucomatous Trabecular Meshwork Cells by Sun, Ying Ying, Bradley, John M, Keller, Kate E

“…Trabecular meshwork (TM) cells detect and coordinate responses to intraocular pressure (IOP) in the eye. TM cells become dysfunctional in glaucoma where IOP is…”
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Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation by Sun, Ying Ying, Yang, Yong-Feng, Keller, Kate E

“…The actin cytoskeleton plays a key role in outflow regulation through the trabecular meshwork (TM). Although actin stress fibers are a target of glaucoma…”
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Nanotubules and Cellular Communication in Trabecular Meshwork Cells by Keller, Kate E, Kaech Petrie, Stefanie

“…Glaucoma causes dysfunction to tissues located in the anterior and posterior eye. In the anterior eye, the trabecular meshwork (TM) is the site of…”
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Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease by Chinnery, Holly R., Keller, Kate E.

“…Cellular communication is an essential process for the development and maintenance of all tissues including the eye. Recently, a new method of cellular…”
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Glaucomatous cell derived matrices differentially modulate non-glaucomatous trabecular meshwork cellular behavior by Raghunathan, Vijay Krishna, Benoit, Julia, Kasetti, Ramesh, Zode, Gulab, Salemi, Michelle, Phinney, Brett S., Keller, Kate E., Staverosky, Julia A., Murphy, Christopher J., Acott, Ted, Vranka, Janice

“…[Display omitted] Ocular hypertension is a causal risk-factor to developing glaucoma. This is associated with stiffening of the trabecular meshwork (TM), the…”
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Tunneling Nanotubes are Novel Cellular Structures That Communicate Signals Between Trabecular Meshwork Cells by Keller, Kate E, Bradley, John M, Sun, Ying Ying, Yang, Yong-Feng, Acott, Ted S

“…The actin cytoskeleton of trabecular meshwork (TM) cells plays a role in regulating aqueous humor outflow. Many studies have investigated stress fibers, but…”
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Profiling IOP-Responsive Genes in the Trabecular Meshwork and Optic Nerve Head in a Rat Model of Controlled Elevation of Intraocular Pressure by Lozano, Diana C, Yang, Yong-Feng, Cepurna, William O, Smoody, Barbara F, Ing, Eliesa, Morrison, John C, Keller, Kate E

“…The rat controlled elevation of intraocular pressure (CEI) model allows study of in vivo responses to short-term exposure to defined intraocular pressures…”
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