Search Results - "Keller, Evan T."

Stromal cells in tumor microenvironment and breast cancer by Mao, Yan, Keller, Evan T., Garfield, David H., Shen, Kunwei, Wang, Jianhua

“…Cancer is a systemic disease encompassing multiple components of both tumor cells themselves and host stromal cells. It is now clear that stromal cells in the…”
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Primary prostate cancer educates bone stroma through exosomal pyruvate kinase M2 to promote bone metastasis by Dai, Jinlu, Escara-Wilke, June, Keller, Jill M, Jung, Younghun, Taichman, Russell S, Pienta, Kenneth J, Keller, Evan T

“…Prostate cancer (PCa) metastasizes selectively to bone through unknown mechanisms. In the current study, we identified exosome-mediated transfer of pyruvate…”
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Integrative differential expression and gene set enrichment analysis using summary statistics for scRNA-seq studies by Ma, Ying, Sun, Shiquan, Shang, Xuequn, Keller, Evan T., Chen, Mengjie, Zhou, Xiang

“…Differential expression (DE) analysis and gene set enrichment (GSE) analysis are commonly applied in single cell RNA sequencing (scRNA-seq) studies. Here, we…”
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Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases by Sottnik, Joseph L, Dai, Jinlu, Zhang, Honglai, Campbell, Brittany, Keller, Evan T

“…Cross-talk between tumor cells and their microenvironment is critical for malignant progression. Cross-talk mediators, including soluble factors and direct…”
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Metformin targets multiple signaling pathways in cancer by Lei, Yong, Yi, Yanhua, Liu, Yang, Liu, Xia, Keller, Evan T, Qian, Chao-Nan, Zhang, Jian, Lu, Yi

“…Metformin, an inexpensive and well-tolerated oral agent commonly used in the first-line treatment of type 2 diabetes,has become the focus of intense research…”
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Apoptosis-induced CXCL5 accelerates inflammation and growth of prostate tumor metastases in bone by Roca, Hernan, Jones, Jacqueline D, Purica, Marta C, Weidner, Savannah, Koh, Amy J, Kuo, Robert, Wilkinson, John E, Wang, Yugang, Daignault-Newton, Stephanie, Pienta, Kenneth J, Morgan, Todd M, Keller, Evan T, Nör, Jacques E, Shea, Lonnie D, McCauley, Laurie K

“…During tumor progression, immune system phagocytes continually clear apoptotic cancer cells in a process known as efferocytosis. However, the impact of…”
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Single-Cell Transcriptomics Analysis Identifies Nuclear Protein 1 as a Regulator of Docetaxel Resistance in Prostate Cancer Cells by Schnepp, Patricia M, Shelley, Greg, Dai, Jinlu, Wakim, Nicole, Jiang, Hui, Mizokami, Atsushi, Keller, Evan T

“…The majority of patients with prostate cancer treated with docetaxel develop resistance to it. To better understand the mechanism behind the acquisition of…”
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MT1-MMP-Dependent Control of Skeletal Stem Cell Commitment via a β1-Integrin/YAP/TAZ Signaling Axis by Tang, Yi, Rowe, R. Grant, Botvinick, Elliot L., Kurup, Abhishek, Putnam, Andrew J., Seiki, Motoharu, Weaver, Valerie M., Keller, Evan T., Goldstein, Steven, Dai, Jinlu, Begun, Dana, Saunders, Thomas, Weiss, Stephen J.

“…In vitro, topographical and biophysical cues arising from the extracellular matrix (ECM) direct skeletal stem cell (SSC) commitment and differentiation…”
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Mangiferin attenuates TH1/TH2 cytokine imbalance in an ovalbumin-induced asthmatic mouse model by Guo, Hong-Wei, Yun, Chen-Xia, Hou, Guang-Han, Du, Jun, Huang, Xin, Lu, Yi, Keller, Evan T, Zhang, Jian, Deng, Jia-Gang

“…Mangiferin is a major bioactive ingredient in Mangifera indica Linn. (Anacardiaceae) leaves. Aqueous extract of such leaves have been used as an indigenous…”
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Polarization of Prostate Cancer-associated Macrophages Is Induced by Milk Fat Globule-EGF Factor 8 (MFG-E8)-mediated Efferocytosis by Soki, Fabiana N., Koh, Amy J., Jones, Jacqueline D., Kim, Yeo Won, Dai, Jinlu, Keller, Evan T., Pienta, Kenneth J., Atabai, Kamran, Roca, Hernan, McCauley, Laurie K.

“…Tumor cells secrete factors that modulate macrophage activation and polarization into M2 type tumor-associated macrophages, which promote tumor growth,…”
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Exosome-derived microRNAs contribute to prostate cancer chemoresistance by Li, Jing, Yang, Xin, Guan, Hao, Mizokami, Atsushi, Keller, Evan T, Xu, Xiaozhen, Liu, Xia, Tan, Jiyong, Hu, Longyuan, Lu, Yi, Zhang, Jian

“…Certain microRNAs (miRNAs) play a key role in cancer cell chemoresistance. However, the pleiotropic functions of exosome-derived miRNAs on developing…”
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Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42–PAK1 axis by Guo, Yaxiu, Zhang, Zhisong, Wei, Huiting, Wang, Jingyu, Lv, Junqiang, Zhang, Kai, Keller, Evan T, Yao, Zhi, Wang, Quan

“…Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections and plays a role in prostatic carcinogenesis and prostate cancer (PCa)…”
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Enterobacter ludwigii protects DSS-induced colitis through choline-mediated immune tolerance by Li, Qianqian, Sun, Xuan, Yu, Kaiyuan, Lv, Junqiang, Miao, Chunhui, Yang, Jianming, Wang, Song, Fu, Zheng, Sun, Yamin, Zhang, Hong, Zhang, Zhi-Song, Keller, Evan T., Yao, Zhi, Wang, Quan

“…Commensal intestinal bacteria play key roles in regulating host immune tolerance; however, bacterial strains and related metabolites directly involved in this…”
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Cabozantinib Inhibits Prostate Cancer Growth and Prevents Tumor-Induced Bone Lesions by JINLU DAI, HONGLAI ZHANG, KARATSINIDES, Andreas, KELLER, Jill M, KOZLOFF, Kenneth M, AFTAB, Dana T, SCHIMMOLLER, Frauke, KELLER, Evan T

“…Cabozantinib, an orally available multityrosine kinase inhibitor with activity against mesenchymal epithelial transition factor (MET) and VEGF receptor 2…”
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Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer by Rupp, Brittany, Owen, Sarah, Ball, Harrison, Smith, Kaylee Judith, Gunchick, Valerie, Keller, Evan T, Sahai, Vaibhav, Nagrath, Sunitha

“…As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into…”
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Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications by Hovelson, Daniel H., Udager, Aaron M., McDaniel, Andrew S., Grivas, Petros, Palmbos, Phillip, Tamura, Shuzo, Lazo de la Vega, Lorena, Palapattu, Ganesh, Veeneman, Brendan, El-Sawy, Layla, Sadis, Seth E., Morgan, Todd M., Montgomery, Jeffrey S., Weizer, Alon Z., Day, Kathleen C., Neamati, Nouri, Liebert, Monica, Keller, Evan T., Day, Mark L., Mehra, Rohit, Tomlins, Scott A.

“…Integrated molecular profiling has identified intrinsic expression-based bladder cancer molecular subtypes. Despite frequent histological diversity, robustness…”
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Cigarette smoke-associated inflammation impairs bone remodeling through NFκB activation by Lu, Yi, Di, Yuanpu Peter, Chang, Ming, Huang, Xin, Chen, Qiuyan, Hong, Ni, Kahkonen, Beth A, Di, Marissa E, Yu, Chunyan, Keller, Evan T, Zhang, Jian

“…Cigarette smoking constitutes a major lifestyle risk factor for osteoporosis and hip fracture. It is reported to impair the outcome of many clinical…”
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Macrofluidic recirculating model of skeletal metastasis by Osawa, Takahiro, Wang, Wenchu, Dai, Jinlu, Keller, Evan T.

“…While microfluidic systems model aspects of metastasis, they are limited to artificially created tissues of limited complexity. We set out to develop an in…”
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Down-regulation of E-cadherin enhances prostate cancer chemoresistance via Notch signaling by Wang, Wenchu, Wang, Lihui, Mizokami, Atsushi, Shi, Junlin, Zou, Chunlin, Dai, Jinlu, Keller, Evan T, Lu, Yi, Zhang, Jian

“…The chemoresistance of prostate cancer (PCa) is invariably associated with the aggressiveness and metastasis of this disease. New emerging evidence indicates…”
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An infection-induced RhoB-Beclin 1-Hsp90 complex enhances clearance of uropathogenic Escherichia coli by Miao, Chunhui, Yu, Mingyu, Pei, Geng, Ma, Zhenyi, Zhang, Lisong, Yang, Jianming, Lv, Junqiang, Zhang, Zhi-Song, Keller, Evan T., Yao, Zhi, Wang, Quan

“…Host cells use several anti-bacterial pathways to defend against pathogens. Here, using a uropathogenic Escherichia coli (UPEC) infection model, we demonstrate…”
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