Search Results - "Kellems, Rodney E."

Comprehensive Characterization of Alternative Polyadenylation in Human Cancer by Xiang, Yu, Ye, Youqiong, Lou, Yanyan, Yang, Yang, Cai, Chunyan, Zhang, Zhao, Mills, Tingting, Chen, Ning-Yuan, Kim, Yoonjin, Muge Ozguc, Fatma, Diao, Lixia, Karmouty-Quintana, Harry, Xia, Yang, Kellems, Rodney E, Chen, Zheng, Blackburn, Michael R, Yoo, Seung-Hee, Shyu, Ann-Bin, Mills, Gordon B, Han, Leng

“…Alternative polyadenylation (APA) is emerging as a major post-transcriptional mechanism for gene regulation, and dysregulation of APA contributes to several…”
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Inflammation, Autoimmunity, and Hypertension: The Essential Role of Tissue Transglutaminase by Liu, Chen, Kellems, Rodney E., Xia, Yang

“…Abstract Inflammatory cytokines cause hypertension when introduced into animals. Additional evidence indicates that cytokines induce the production of…”
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Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia by Sun, Kaiqi, Zhang, Yujin, D’Alessandro, Angelo, Nemkov, Travis, Song, Anren, Wu, Hongyu, Liu, Hong, Adebiyi, Morayo, Huang, Aji, Wen, Yuan E., Bogdanov, Mikhail V., Vila, Alejandro, O’Brien, John, Kellems, Rodney E., Dowhan, William, Subudhi, Andrew W., Jameson-Van Houten, Sonja, Julian, Colleen G., Lovering, Andrew T., Safo, Martin, Hansen, Kirk C., Roach, Robert C., Xia, Yang

“…Sphingosine-1-phosphate (S1P) is a bioactive signalling lipid highly enriched in mature erythrocytes, with unknown functions pertaining to erythrocyte…”
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Interleukin 6 Underlies Angiotensin II–Induced Hypertension and Chronic Renal Damage by Zhang, Weiru, Wang, Wei, Yu, Hong, Zhang, Yujin, Dai, Yingbo, Ning, Chen, Tao, Lijian, Sun, Hong, Kellems, Rodney E, Blackburn, Michael R, Xia, Yang

“…Chronic kidney disease (CKD) is a prevalent life-threatening disease frequently associated with hypertension, progression to renal fibrosis, and eventual renal…”
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Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice by Irani, Roxanna A, Ramin, Susan M, Zhou, Cissy C, Popek, Edwina J, Zhang, Yujin, Hicks, M John, Mi, Tiejuan, Kellems, Rodney E, Xia, Yang, Zhang, Hong

“…Pre-eclampsia affects approximately 5% of pregnancies and remains a leading cause of maternal and neonatal mortality and morbidity in the United States and the…”
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Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude Hypoxia by Liu, Hong, Zhang, Yujin, Wu, Hongyu, D’Alessandro, Angelo, Yegutkin, Gennady G, Song, Anren, Sun, Kaiqi, Li, Jessica, Cheng, Ning-Yuan, Huang, Aji, Edward Wen, Yuan, Weng, Ting Ting, Luo, Fayong, Nemkov, Travis, Sun, Hong, Kellems, Rodney E, Karmouty-Quintana, Harry, Hansen, Kirk C, Zhao, Bihong, Subudhi, Andrew W, Jameson-Van Houten, Sonja, Julian, Colleen G, Lovering, Andrew T, Eltzschig, Holger K, Blackburn, Michael R, Roach, Robert C, Xia, Yang

“…BACKGROUND:High altitude is a challenging condition caused by insufficient oxygen supply. Inability to adjust to hypoxia may lead to pulmonary edema, stroke,…”
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Sphingosine‐1‐phosphate receptor 1 mediates elevated IL‐6 signaling to promote chronic inflammation and multitissue damage in sickle cell disease by Zhao, Shushan, Adebiyi, Morayo G., Zhang, Yujin, Couturier, Jacob P., Fan, Xuegong, Zhang, Hongqi, Kellems, Rodney E., Lewis, Dorothy E., Xia, Yang

“…Sphingosine‐1‐phosphate (S1P) is a biolipid involved in chronic inflammation in several inflammatory disorders. Recent studies revealed that elevated S1P…”
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Erythrocytes retain hypoxic adenosine response for faster acclimatization upon re-ascent by Song, Anren, Zhang, Yujin, Han, Leng, Yegutkin, Gennady G., Liu, Hong, Sun, Kaiqi, D’Alessandro, Angelo, Li, Jessica, Karmouty-Quintana, Harry, Iriyama, Takayuki, Weng, Tingting, Zhao, Shushan, Wang, Wei, Wu, Hongyu, Nemkov, Travis, Subudhi, Andrew W., Jameson-Van Houten, Sonja, Julian, Colleen G., Lovering, Andrew T., Hansen, Kirk C., Zhang, Hong, Bogdanov, Mikhail, Dowhan, William, Jin, Jianping, Kellems, Rodney E., Eltzschig, Holger K., Blackburn, Michael, Roach, Robert C., Xia, Yang

“…Faster acclimatization to high altitude upon re-ascent is seen in humans; however, the molecular basis for this enhanced adaptive response is unknown. We…”
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Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression by Zhang, Yujin, Berka, Vladimir, Song, Anren, Sun, Kaiqi, Wang, Wei, Zhang, Weiru, Ning, Chen, Li, Chonghua, Zhang, Qibo, Bogdanov, Mikhail, Alexander, Danny C, Milburn, Michael V, Ahmed, Mostafa H, Lin, Han, Idowu, Modupe, Zhang, Jun, Kato, Gregory J, Abdulmalik, Osheiza Y, Zhang, Wenzheng, Dowhan, William, Kellems, Rodney E, Zhang, Pumin, Jin, Jianping, Safo, Martin, Tsai, Ah-Lim, Juneja, Harinder S, Xia, Yang

“…Sphingosine-1-phosphate (S1P) is a bioactive lipid that regulates multicellular functions through interactions with its receptors on cell surfaces. S1P is…”
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Elevated placental adenosine signaling contributes to the pathogenesis of preeclampsia by Iriyama, Takayuki, Sun, Kaiqi, Parchim, Nicholas F, Li, Jessica, Zhao, Cheng, Song, Anren, Hart, Laura A, Blackwell, Sean C, Sibai, Baha M, Chan, Lee-Nien L, Chan, Teh-Sheng, Hicks, M John, Blackburn, Michael R, Kellems, Rodney E, Xia, Yang

“…Preeclampsia is a prevalent hypertensive disorder of pregnancy and a leading cause of maternal and neonatal morbidity and mortality worldwide. This pathogenic…”
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Detrimental effects of adenosine signaling in sickle cell disease by Xia, Yang, Zhang, Yujin, Dai, Yingbo, Wen, Jiaming, Zhang, Weiru, Grenz, Almut, Sun, Hong, Tao, Lijian, Lu, Guangxiu, Alexander, Danny C, Milburn, Michael V, Carter-Dawson, Louvenia, Lewis, Dorothy E, Zhang, Wenzheng, Eltzschig, Holger K, Kellems, Rodney E, Blackburn, Michael R, Juneja, Harinder S

“…Yujin Zhang et al . discovered that the concentration of adenosine in the blood is increased both in a mouse model of sickle cell disease and in humans with…”
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Erythrocyte adenosine A2B receptor prevents cognitive and auditory dysfunction by promoting hypoxic and metabolic reprogramming by Qiang, Qingfen, Manalo, Jeanne M, Sun, Hong, Zhang, Yujin, Song, Anren, Wen, Alexander Q, Wen, Y Edward, Chen, Changhan, Liu, Hong, Cui, Ying, Nemkov, Travis, Reisz, Julie A, Edwards Iii, George, Perreira, Fred A, Kellems, Rodney E, Soto, Claudio, D'Alessandro, Angelo, Xia, Yang

“…Hypoxia drives aging and promotes age-related cognition and hearing functional decline. Despite the role of erythrocytes in oxygen (O2) transport, their role…”
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Elevated Adenosine Induces Placental DNA Hypomethylation Independent of A2B Receptor Signaling in Preeclampsia by Huang, Aji, Wu, Hongyu, Iriyama, Takayuki, Zhang, Yujin, Sun, Kaiqi, Song, Anren, Liu, Hong, Peng, Zhangzhe, Tang, Lili, Lee, Minjung, Huang, Yun, Ni, Xin, Kellems, Rodney E, Xia, Yang

“…Preeclampsia is a prevalent pregnancy hypertensive disease with both maternal and fetal morbidity and mortality. Emerging evidence indicates that global…”
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Autoantibody-mediated IL-6-dependent endothelin-1 elevation underlies pathogenesis in a mouse model of preeclampsia by Zhou, Cissy Chenyi, Irani, Roxanna A, Dai, Yingbo, Blackwell, Sean C, Hicks, M John, Ramin, Susan M, Kellems, Rodney E, Xia, Yang

“…Preeclampsia (PE) is a life-threatening hypertensive disorder of pregnancy. Elevated circulating endothelin-1 (ET-1) is associated with the disease. However…”
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Elevated adenosine signaling via adenosine A2B receptor induces normal and sickle erythrocyte sphingosine kinase 1 activity by Sun, Kaiqi, Zhang, Yujin, Bogdanov, Mikhail V., Wu, Hongyu, Song, Anren, Li, Jessica, Dowhan, William, Idowu, Modupe, Juneja, Harinder S., Molina, Jose G., Blackburn, Michael R., Kellems, Rodney E., Xia, Yang

“…Erythrocyte possesses high sphingosine kinase 1 (SphK1) activity and is the major cell type supplying plasma sphingosine-1-phosphate, a signaling lipid…”
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Elevated Ecto-5ʼ-nucleotidase-Mediated Increased Renal Adenosine Signaling Via A2B Adenosine Receptor Contributes to Chronic Hypertension by Zhang, Weiru, Zhang, Yujin, Wang, Wei, Dai, Yingbo, Ning, Chen, Luo, Renna, Sun, Kaiqi, Glover, Louise, Grenz, Almut, Sun, Hong, Tao, Lijian, Zhang, Wenzheng, Colgan, Sean P, Blackburn, Michael R, Eltzschig, Holger K, Kellems, Rodney E, Xia, Yang

“…RATIONALE:Hypertension is the most prevalent life-threatening disease worldwide and is frequently associated with chronic kidney disease (CKD). However, the…”
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Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease by Sun, Kaiqi, D’Alessandro, Angelo, Ahmed, Mostafa H., Zhang, Yujin, Song, Anren, Ko, Tzu-Ping, Nemkov, Travis, Reisz, Julie A., Wu, Hongyu, Adebiyi, Morayo, Peng, Zhangzhe, Gong, Jing, Liu, Hong, Huang, Aji, Wen, Yuan Edward, Wen, Alexander Q., Berka, Vladimir, Bogdanov, Mikhail V., Abdulmalik, Osheiza, Han, Leng, Tsai, Ah-lim, Idowu, Modupe, Juneja, Harinder S., Kellems, Rodney E., Dowhan, William, Hansen, Kirk C., Safo, Martin K., Xia, Yang

“…Elevated sphingosine 1-phosphate (S1P) is detrimental in Sickle Cell Disease (SCD), but the mechanistic basis remains obscure. Here, we report that increased…”
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Sustained Elevated Adenosine via ADORA2B Promotes Chronic Pain through Neuro-immune Interaction by Hu, Xia, Adebiyi, Morayo G., Luo, Jialie, Sun, Kaiqi, Le, Thanh-Thuy T., Zhang, Yujin, Wu, Hongyu, Zhao, Shushan, Karmouty-Quintana, Harry, Liu, Hong, Huang, Aji, Wen, Yuan Edward, Zaika, Oleg L., Mamenko, Mykola, Pochynyuk, Oleh M., Kellems, Rodney E., Eltzschig, Holger K., Blackburn, Michael R., Walters, Edgar T., Huang, Dong, Hu, Hongzhen, Xia, Yang

“…The molecular mechanisms of chronic pain are poorly understood and effective mechanism-based treatments are lacking. Here, we report that mice lacking…”
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Increased LIGHT leading to sFlt-1 elevation underlies the pathogenic link between hydatidiform mole and preeclampsia by Iriyama, Takayuki, Wang, Guan, Yoshikawa, Midori, Mimura, Nobuko, Matsui, Haruka, Sayama, Seisuke, Kumasawa, Keiichi, Nagamatsu, Takeshi, Koga, Kaori, Kotani, Tomomi, Niimi, Kaoru, Yamamoto, Eiko, Kellems, Rodney E., Xia, Yang, Osuga, Yutaka, Fujii, Tomoyuki

“…Hydatidiform moles are known to pose an extremely high risk of severe early-onset preeclampsia if left untreated. TNF superfamily cytokine, LIGHT has recently…”
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Angiotensin II Induces Soluble fms-Like Tyrosine Kinase-1 Release via Calcineurin Signaling Pathway in Pregnancy by Zhou, Cissy Chenyi, Ahmad, Shakil, Mi, TieJuan, Xia, Lingwei, Abbasi, Shahrzad, Hewett, Peter W, Sun, ChunXiao, Ahmed, Asif, Kellems, Rodney E, Xia, Yang

“…Maternal endothelial dysfunction in preeclampsia is associated with increased soluble fms-like tyrosine kinase-1 (sFlt-1), a circulating antagonist of vascular…”
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