Search Results - "Kelleher, Neil L"

Proteoforms as the next proteomics currency by Smith, Lloyd M, Kelleher, Neil L

“…Identifying precise molecular forms of proteins can improve our understanding of function Proteoforms—the different forms of proteins produced from the genome…”
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Top Down proteomics: Facts and perspectives by Catherman, Adam D., Skinner, Owen S., Kelleher, Neil L.

“…•Top Down versus Bottom Up proteomics analysis.•Separations methods for Top Down proteomics.•Developments in mass spectrometry instrumentation and…”
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Progress in Top-Down Proteomics and the Analysis of Proteoforms by Toby, Timothy K, Fornelli, Luca, Kelleher, Neil L

“…From a molecular perspective, enactors of function in biology are intact proteins that can be variably modified at the genetic, transcriptional, or…”
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Precision proteomics: The case for high resolution and high mass accuracy by Mann, Matthias, Kelleher, Neil L

“…Proteomics has progressed radically in the last 5 years and is now on par with most genomic technologies in throughput and comprehensiveness. Analyzing peptide…”
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Decoding protein modifications using top-down mass spectrometry by Siuti, Nertila, Kelleher, Neil L

“…Top-down mass spectrometry is an emerging technology which strives to preserve the post-translationally modified forms of proteins present in vivo by measuring…”
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Metabolomics and genomics in natural products research: complementary tools for targeting new chemical entities by Caesar, Lindsay K, Montaser, Rana, Keller, Nancy P, Kelleher, Neil L

“…Covering: 2010 to 2021Organisms in nature have evolved into proficient synthetic chemists, utilizing specialized enzymatic machinery to biosynthesize an…”
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A computational framework to explore large-scale biosynthetic diversity by Navarro-Muñoz, Jorge C., Selem-Mojica, Nelly, Mullowney, Michael W., Kautsar, Satria A., Tryon, James H., Parkinson, Elizabeth I., De Los Santos, Emmanuel L. C., Yeong, Marley, Cruz-Morales, Pablo, Abubucker, Sahar, Roeters, Arne, Lokhorst, Wouter, Fernandez-Guerra, Antonio, Cappelini, Luciana Teresa Dias, Goering, Anthony W., Thomson, Regan J., Metcalf, William W., Kelleher, Neil L., Barona-Gomez, Francisco, Medema, Marnix H.

“…Genome mining has become a key technology to exploit natural product diversity. Although initially performed on a single-genome basis, the process is now being…”
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Epiproteomics: quantitative analysis of histone marks and codes by mass spectrometry by Zheng, Yupeng, Huang, Xiaoxiao, Kelleher, Neil L

“…[Display omitted] •A useful reference for quantitative analysis of histone modifications.•Three general approaches to analyze histone modifications by mass…”
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Proteoform: a single term describing protein complexity by Smith, Lloyd M, Kelleher, Neil L

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Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas by Piunti, Andrea, Hashizume, Rintaro, Morgan, Marc A, Bartom, Elizabeth T, Horbinski, Craig M, Marshall, Stacy A, Rendleman, Emily J, Ma, Quanhong, Takahashi, Yoh-hei, Woodfin, Ashley R, Misharin, Alexander V, Abshiru, Nebiyu A, Lulla, Rishi R, Saratsis, Amanda M, Kelleher, Neil L, James, C David, Shilatifard, Ali

“…Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however,…”
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Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation by Shaw, Jared B, Li, Wenzong, Holden, Dustin D, Zhang, Yan, Griep-Raming, Jens, Fellers, Ryan T, Early, Bryan P, Thomas, Paul M, Kelleher, Neil L, Brodbelt, Jennifer S

“…The top-down approach to proteomics offers compelling advantages due to the potential to provide complete characterization of protein sequence and…”
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The Human Proteoform Atlas: a FAIR community resource for experimentally derived proteoforms by Hollas, Michael A R, Robey, Matthew T, Fellers, Ryan T, LeDuc, Richard D, Thomas, Paul M, Kelleher, Neil L

“…Abstract The Human Proteoform Atlas (HPfA) is a web-based repository of experimentally verified human proteoforms on-line at http://human-proteoform-atlas.org…”
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Mutant-IDH1-dependent chromatin state reprogramming, reversibility, and persistence by Turcan, Sevin, Makarov, Vladimir, Taranda, Julian, Wang, Yuxiang, Fabius, Armida W. M., Wu, Wei, Zheng, Yupeng, El-Amine, Nour, Haddock, Sara, Nanjangud, Gouri, LeKaye, H. Carl, Brennan, Cameron, Cross, Justin, Huse, Jason T., Kelleher, Neil L., Osten, Pavel, Thompson, Craig B., Chan, Timothy A.

“…Mutations in IDH1 and IDH2 (encoding isocitrate dehydrogenase 1 and 2) drive the development of gliomas and other human malignancies. Mutant IDH1 induces…”
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Identification and Quantification of Proteoforms by Mass Spectrometry by Schaffer, Leah V., Millikin, Robert J., Miller, Rachel M., Anderson, Lissa C., Fellers, Ryan T., Ge, Ying, Kelleher, Neil L., LeDuc, Richard D., Liu, Xiaowen, Payne, Samuel H., Sun, Liangliang, Thomas, Paul M., Tucholski, Trisha, Wang, Zhe, Wu, Si, Wu, Zhijie, Yu, Dahang, Shortreed, Michael R., Smith, Lloyd M.

“…A proteoform is a defined form of a protein derived from a given gene with a specific amino acid sequence and localized post‐translational modifications. In…”
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A Cell-Based Approach to the Human Proteome Project by Kelleher, Neil L.

“…The general scope of a project to determine the protein molecules that comprise the cells within the human body is framed. By focusing on protein primary…”
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Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids by Martin, Rey W., Des Soye, Benjamin J., Kwon, Yong-Chan, Kay, Jennifer, Davis, Roderick G., Thomas, Paul M., Majewska, Natalia I., Chen, Cindy X., Marcum, Ryan D., Weiss, Mary Grace, Stoddart, Ashleigh E., Amiram, Miriam, Ranji Charna, Arnaz K., Patel, Jaymin R., Isaacs, Farren J., Kelleher, Neil L., Hong, Seok Hoon, Jewett, Michael C.

“…Cell-free protein synthesis has emerged as a powerful approach for expanding the range of genetically encoded chemistry into proteins. Unfortunately, efforts…”
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A Highly Productive, One-Pot Cell-Free Protein Synthesis Platform Based on Genomically Recoded Escherichia coli by Des Soye, Benjamin J, Gerbasi, Vincent R, Thomas, Paul M, Kelleher, Neil L, Jewett, Michael C

“…The site-specific incorporation of non-canonical amino acids (ncAAs) into proteins via amber suppression provides access to novel protein properties,…”
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On the Scalability and Requirements of Whole Protein Mass Spectrometry by Compton, Philip D, Zamdborg, Leonid, Thomas, Paul M, Kelleher, Neil L

“…Top-down proteomics has improved over the past decade despite the significant challenges presented by the analysis of large protein ions. Here, the detection…”
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Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability by Rickels, Ryan, Herz, Hans-Martin, Sze, Christie C, Cao, Kaixiang, Morgan, Marc A, Collings, Clayton K, Gause, Maria, Takahashi, Yoh-hei, Wang, Lu, Rendleman, Emily J, Marshall, Stacy A, Krueger, Annika, Bartom, Elizabeth T, Piunti, Andrea, Smith, Edwin R, Abshiru, Nebiyu A, Kelleher, Neil L, Dorsett, Dale, Shilatifard, Ali

“…Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants…”
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Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids by Amiram, Miriam, Haimovich, Adrian D, Fan, Chenguang, Wang, Yane-Shih, Aerni, Hans-Rudolf, Ntai, Ioanna, Moonan, Daniel W, Ma, Natalie J, Rovner, Alexis J, Hong, Seok Hoon, Kelleher, Neil L, Goodman, Andrew L, Jewett, Michael C, Söll, Dieter, Rinehart, Jesse, Isaacs, Farren J

“…Non-standard amino acids are incorporated into proteins at large numbers of sites using evolved translation components in recoded bacteria. Expansion of the…”
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