Search Results - "Kellam, B"

Agonist-occupied A₃ adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells by Cordeaux, Y, Briddon, S.J, Alexander, S.P.H, Kellam, B, Hill, S.J

“…G protein-coupled receptors are known to be organized within different membrane compartments or microdomains of individual cells. Here, we have used a…”
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Noise-induced sleep disruption from wind turbines: scientific updates and acoustical standards by Ellenbogen, Jeffrey M, Kellam, Colleen B, Hankard, Michael

“…Abstract Wind energy appears to place global environmental benefits against local human health, particularly sleep. The result is a significant challenge to…”
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Surface engineering of living myoblasts via selective periodate oxidation by De Bank, P. A., Kellam, B., Kendall, D. A., Shakesheff, K. M.

“…Cell surface molecules are vital for normal cell activity. To study the functions of these molecules or manipulate cell behavior, the ability to decorate cell…”
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Quantitative Analysis of the Formation and Diffusion of A1-Adenosine Receptor-Antagonist Complexes in Single Living Cells by Briddon, S. J., Middleton, R. J., Cordeaux, Y., Flavin, F. M., Weinstein, J. A., George, M. W., Kellam, B., Hill, S. J., Black, James W.

“…The A1-adenosine receptor ( A1- AR) is a G protein-coupled receptor that mediates many of the physiological effects of adenosine in the brain, heart, kidney,…”
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Fluorophore-tagged GPCR ligands by Middleton, Richard J, Kellam, Barrie

“…Fluorescently tagged drug molecules can be successfully employed to visualize the location of their receptor target at the single-cell level. Furthermore, if…”
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Quantitative analysis of the formation and diffusion of A 1 -adenosine receptor-antagonist complexes in single living cells by Briddon, S. J., Middleton, R. J., Cordeaux, Y., Flavin, F. M., Weinstein, J. A., George, M. W., Kellam, B., Hill, S. J.

“…The A 1 -adenosine receptor (A 1 -AR) is a G protein-coupled receptor that mediates many of the physiological effects of adenosine in the brain, heart, kidney,…”
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Tenderfoot Preemie vs a manual lancet: a clinical evaluation by Kellam, B, Sacks, L M, Wailer, J L, Kathen, C, McLaurin, C, Doster, C, Schnaible, S, Youmans, M

“…To compare the amount of time required to collect a blood specimen, the number of heel punctures required, and the rate of hematology re-collections required…”
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Chemical modification of mammalian cell surfaces by Kellam, Barrie, De Bank, Paul A, Shakesheff, Kevin M

“…The mammalian cell surface is a highly heterogeneous chemical environment with proteins, carbohydrates, lipids and composite molecules controlling vital cell…”
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Using extended pedigrees to identify novel autism spectrum disorder (ASD) candidate genes by Woodbury-Smith, Marc, Paterson, Andrew D., Thiruvahindrapduram, Bhooma, Lionel, Anath C., Marshall, Christian R., Merico, Daniele, Fernandez, Bridget A., Duku, Eric, Sutcliffe, James S., O’Conner, Irene, Chrysler, Christina, Thompson, Ann, Kellam, Barbara, Tammimies, Kristiina, Walker, Susan, Yuen, Ryan K. C., Uddin, Mohammed, Howe, Jennifer L., Parlier, Morgan, Whitten, Kathy, Szatmari, Peter, Vieland, Veronica J., Piven, Joseph, Scherer, Stephen W.

“…Copy number variation has emerged as an important cause of phenotypic variation, particularly in relation to some complex disorders. Autism spectrum disorder…”
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Clot lysis for thrombosed central venous catheters in pediatric patients by Kellam, B, Fraze, D, Kanarek, K S

“…Central venous catheters (CVC) in pediatric patients provide a reliable method for administration of total parenteral nutrition and chemotherapy. Catheter…”
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Agonist‐occupied A 3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells by Cordeaux, Y., Briddon, S. J., Alexander, S. P. H., Kellam, B., Hill, S. J.

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Isolation and characterization of a previously unrecognized myosin heavy chain gene present in the Syrian hamster by McCully, J D, Wang, R X, Kellam, B, Sole, M J, Liew, C C

“…A full length (25,000 base-pair) myosin heavy chain gene completely contained within a single cosmid clone was isolated from a Syrian hamster cosmid genomic…”
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Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor by Yates, Andrew S, Doughty, Stephen W, Kendall, David A, Kellam, Barrie

“…In silico modelling was used to guide the positioning of the fluorescent dye NBD-F on the cannabinoid CB2 receptor agonist JWH-015. While the ultimate…”
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Binding of the Anticancer Prodrug CB1954 to the Activating Enzyme NQO2 Revealed by the Crystal Structure of Their Complex by AbuKhader, Majed, Heap, John, De Matteis, Cristina, Kellam, Barrie, Doughty, Stephen W, Minton, Nigel, Paoli, Massimo

“…CB1954 is an attractive prodrug for directed-enzyme prodrug therapy (DEPT) and a conventional prodrug against tumors in which the enzyme NQO2 is highly…”
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New Fluorescent Adenosine A sub(1)-Receptor Agonists That Allow Quantification of Ligand-Receptor Interactions in Microdomains of Single Living Cells by Middleton, R J, Briddon, S J, Cordeaux, Y, Yates, A S, Dale, CL, George, M W, Baker, J G, Hill, S J, Kellam, B

“…Fluorescence spectroscopy is becoming a valuable addition to the array of techniques available for scrutinizing ligand-receptor interactions in biological…”
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Convenient syntheses of (3 S,5 S)-carbapenam-3-carboxylates and their biosynthetic relevance by Bycroft, Barrie W, Chhabra, Siri Ram, Kellam, Barrie, Smith, Paul

“…Starting from readily available glutamate derivatives, facile stereoselective syntheses of (3 S,5 S)-carbapenam-3-carboxylates have been developed. Their…”
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Generalized Quasilinear Simulation of Turbulent Channel Flow by Kellam, Colleen B

“…Direct numerical simulation (DNS) of wall-bounded turbulent flows in physically relevant parameter regimes remains infeasible in many cases of practical…”
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Application of fluorescence correlation spectroscopy to the measurement of agonist binding to a G-protein coupled receptor at the single cell level by Briddon, Stephen J, Middleton, Richard J, Yates, Andrew S, George, Michael W, Kellam, Barrie, Hill, Stephen J

“…The A1-adenosine receptor (A1-AR) is a member of the G-protein coupled receptor superfamily, which has significant pathophysiological importance in disorders…”
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N α-Dmc protected amino acid aglycones: versatile hydrogenolysis stable acceptors for O-glycosylation by Kellam, Barrie, Ward, Paul A., Abdul Rahim, Aisyah S., Chhabra, Siri Ram

“…[Display omitted] N α-(4,4-Dimethyl-2,6-dioxocyclohexylidenemethylene) (Dmc) protected l-serine, l-threonine and l-homoserine have been prepared as tert-butyl…”
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Solid phase synthesis of C-terminal carbohydrate modified enkephalins by Drouillat, Bruno, Kellam, Barrie, Dekany, Gyula, Starr, Mike S., Toth, Istvan

“…1-Azido-2,3,4-tri- O-acetyl- β-D-glucuronic acid ( 1), immobilised on 2-chlorotrityl and NovaSyn TGR resin, was efficiently reduced to its corresponding resin…”
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