Search Results - "Kell, B"

Large-scale sequestration of atmospheric carbon via plant roots in natural and agricultural ecosystems: why and how by Kell, Douglas B.

“…The soil holds twice as much carbon as does the atmosphere, and most soil carbon is derived from recent photosynthesis that takes carbon into root structures…”
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Breeding crop plants with deep roots: their role in sustainable carbon, nutrient and water sequestration by Kell, Douglas B.

“…• Background The soil represents a reservoir that contains at least twice as much carbon as does the atmosphere, yet (apart from 'root crops') mainly just the…”
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The Biology of Lactoferrin, an Iron-Binding Protein That Can Help Defend Against Viruses and Bacteria by Kell, Douglas B., Heyden, Eugene L., Pretorius, Etheresia

“…Lactoferrin is a nutrient classically found in mammalian milk. It binds iron and is transferred via a variety of receptors into and between cells, serum, bile,…”
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The Transporter-Mediated Cellular Uptake and Efflux of Pharmaceutical Drugs and Biotechnology Products: How and Why Phospholipid Bilayer Transport Is Negligible in Real Biomembranes by Kell, Douglas B

“…Over the years, my colleagues and I have come to realise that the likelihood of pharmaceutical drugs being able to diffuse through whatever unhindered…”
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Persistent clotting protein pathology in Long COVID/Post-Acute Sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin by Pretorius, Etheresia, Vlok, Mare, Venter, Chantelle, Bezuidenhout, Johannes A., Laubscher, Gert Jacobus, Steenkamp, Janami, Kell, Douglas B.

“…Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is…”
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The dormant blood microbiome in chronic, inflammatory diseases by Potgieter, Marnie, Bester, Janette, Kell, Douglas B., Pretorius, Etheresia

“…Blood in healthy organisms is seen as a ‘sterile’ environment: it lacks proliferating microbes. Dormant or not-immediately-culturable forms are not absent,…”
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Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently by Currin, Andrew, Swainston, Neil, Day, Philip J, Kell, Douglas B

“…The amino acid sequence of a protein affects both its structure and its function. Thus, the ability to modify the sequence, and hence the structure and…”
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FragNet, a Contrastive Learning-Based Transformer Model for Clustering, Interpreting, Visualizing, and Navigating Chemical Space by Shrivastava, Aditya Divyakant, Kell, Douglas B

“…The question of molecular similarity is core in cheminformatics and is usually assessed via a comparison based on vectors of properties or molecular…”
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Implications of endogenous roles of transporters for drug discovery: hitchhiking and metabolite-likeness by Kell, Douglas B.

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Proteomic Evidence for Amyloidogenic Cross-Seeding in Fibrinaloid Microclots by Kell, Douglas B, Pretorius, Etheresia

“…In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein monomers, with protofibrils and fibrils exhibiting a cross-β…”
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SARS-CoV-2 spike protein S1 induces fibrin(ogen) resistant to fibrinolysis: implications for microclot formation in COVID-19 by Grobbelaar, Lize M., Venter, Chantelle, Vlok, Mare, Ngoepe, Malebogo, Laubscher, Gert Jacobus, Lourens, Petrus Johannes, Steenkamp, Janami, Kell, Douglas B., Pretorius, Etheresia

“…Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection, the cause of coronavirus disease 2019 (COVID-19), is characterized by…”
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Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19 (PASC) by Pretorius, Etheresia, Venter, Chantelle, Laubscher, Gert Jacobus, Kotze, Maritha J, Oladejo, Sunday O, Watson, Liam R, Rajaratnam, Kanshu, Watson, Bruce W, Kell, Douglas B

“…Fibrin(ogen) amyloid microclots and platelet hyperactivation previously reported as a novel finding in South African patients with the coronavirus 2019 disease…”
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Proteomics of fibrin amyloid microclots in long COVID/post-acute sequelae of COVID-19 (PASC) shows many entrapped pro-inflammatory molecules that may also contribute to a failed fibrinolytic system by Kruger, Arneaux, Vlok, Mare, Turner, Simone, Venter, Chantelle, Laubscher, Gert Jacobus, Kell, Douglas B, Pretorius, Etheresia

“…Post-acute sequelae of COVID-19 (PASC), also now known as long COVID, has become a major global health and economic burden. Previously, we provided evidence…”
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Computational cluster validation in post-genomic data analysis by Handl, Julia, Knowles, Joshua, Kell, Douglas B.

“…Motivation The discovery of novel biological knowledge from the ab initio analysis of post-genomic data relies upon the use of unsupervised processing methods,…”
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Erythrocyte, Platelet, Serum Ferritin, and P-Selectin Pathophysiology Implicated in Severe Hypercoagulation and Vascular Complications in COVID-19 by Venter, Chantelle, Bezuidenhout, Johannes Andries, Laubscher, Gert Jacobus, Lourens, Petrus Johannes, Steenkamp, Janami, Kell, Douglas B, Pretorius, Etheresia

“…Progressive respiratory failure is seen as a major cause of death in severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2)-induced infection. Relatively…”
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Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes by Grobler, Corlia, Maphumulo, Siphosethu C, Grobbelaar, L Mireille, Bredenkamp, Jhade C, Laubscher, Gert J, Lourens, Petrus J, Steenkamp, Janami, Kell, Douglas B, Pretorius, Etheresia

“…Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), also known as coronavirus disease 2019 (COVID-19)-induced infection, is strongly associated with…”
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The biology of ergothioneine, an antioxidant nutraceutical by Borodina, Irina, Kenny, Louise C., McCarthy, Cathal M., Paramasivan, Kalaivani, Pretorius, Etheresia, Roberts, Timothy J., van der Hoek, Steven A., Kell, Douglas B.

“…Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes,…”
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Systems biology, metabolic modelling and metabolomics in drug discovery and development by Kell, Douglas B.

“…Unlike signalling pathways, metabolic networks are subject to strict stoichiometric constraints. Metabolomics amplifies changes in the proteome, and represents…”
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The Role of Lipopolysaccharide-Induced Cell Signalling in Chronic Inflammation by Page, Martin J., Kell, Douglas B., Pretorius, Etheresia

“…Lipopolysaccharide (LPS) is the main structural component of the outer membrane of most Gram-negative bacteria and has diverse immunostimulatory and…”
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Is Porphyromonas gingivalis involved in Parkinson’s disease? by Olsen, Ingar, Kell, Douglas B., Pretorius, Etheresia

“…Porphyromonas gingivalis , a major subgingival plaque bacterium in periodontitis, has recently attracted much attention as a possible microbial driver in…”
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