A Mixed-Methods Assessment of the Feasibility of Conducting Neurosurgical Clinical Research in Uganda

A Mixed-Methods Assessment of the Feasibility of Conducting Neurosurgical Clinical Research in Uganda

Clinical research is necessary to evaluate neurosurgical interventions, yet clinical trials are conducted less frequently in low- and middle-income countries. Because specific barriers, facilitating factors, and strategies for neurosurgical clinical research in Uganda have not been previously identi...

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Published in:World neurosurgery Vol. 183; pp. e71 - e87
Main Authors: Petitt, Zoey, Ordonez, Yesel Trillo, Kelkar, Yuveer, Shakir, Muhammad, Ott, Maura, Patel, Yash, Agwu, Chibueze, Khalafallah, Adham M., Mullikin, Alexandria, Tang, Alan, Davis, Jenna, Ssembatya, Joseph Mary, Choi, Shinbe, Deng, Di D., Headley, Jennifer, Obiga, Oscar, Haglund, Michael M., Fuller, Anthony T.
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-03-2024
Subjects:
Data collection
Feasibility
Feasibility Studies
Global neurosurgery
Hospitals
Humans
Neurosurgery
Neurosurgical Procedures
Neurosurgical research
Uganda
Uganda
FGD
RCT
HIC
Research
Global neurosurgery
MNRH
HIV
Neurosurgical research
GCS
Data collection
LMIC
Uganda
Feasibility
TBI
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Summary:Clinical research is necessary to evaluate neurosurgical interventions, yet clinical trials are conducted less frequently in low- and middle-income countries. Because specific barriers, facilitating factors, and strategies for neurosurgical clinical research in Uganda have not been previously identified, this study evaluated neurosurgical providers' perspectives on clinical research and documentation patterns of neurosurgical variables at Mulago National Referral Hospital. Retrospective review of 166 neurosurgical patient charts assessed the frequency of documentation of key variables. Twenty-two providers working in neurosurgery participated in 6 focus group discussions with qualitative analysis utilizing the framework method. Chart review showed that primary diagnosis (99.4%), pupil light response (97.6%), and computed tomography scan results (93.3%) were documented for most patients. Cranial nerve exam (61.5%), pupil size (69.9%), and time to neurosurgical intervention (45%) were documented less frequently. On average, Glasgow Coma Scale was documented for 86.6% of days hospitalized, while vital signs were documented for 12.3%. In most focus group discussions, participants identified follow-up, financing, recruitment, time, approval, and sociocultural factors as research barriers. Participants described how the current health workforce facilitates successful research. To improve research capacity, suggested strategies focused on research networks, data collection, leadership, participant recruitment, infrastructure, and implementation. At Mulago National Referral Hospital, there was variability in the frequency of documentation of neurosurgical variables, which may impact data collection for future studies. While multiple barriers were identified, sociocultural, financing, and time barriers greatly impacted neurosurgical clinical research. Despite that, identified facilitating factors and strategies could be utilized to support neurosurgical research capacity growth.
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ISSN:1878-8750
1878-8769
1878-8769
DOI:10.1016/j.wneu.2023.11.079