Search Results - "Kelher, Marguerite R."

Structural organization of the neutrophil NADPH oxidase: phosphorylation and translocation during priming and activation by Sheppard, Forest R., Kelher, Marguerite R., Moore, Ernest E., McLaughlin, Nathan J. D., Banerjee, Anirban, Silliman, Christopher C.

“…The reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is part of the microbicidal arsenal used by human polymorphonuclear neutrophils (PMNs)…”
Get full text

Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury by Khan, Samina Yasmin, Kelher, Marguerite R., Heal, Joanna M., Blumberg, Neil, Boshkov, Lynn K., Phipps, Richard, Gettings, Kelly F., McLaughlin, Nathan J., Silliman, Christopher C.

“…Transfusion-related acute lung injury (TRALI) is a form of posttransfusion acute pulmonary insufficiency that has been linked to the infusion of biologic…”
Get full text

Plasma from stored packed red blood cells and MHC class I antibodies causes acute lung injury in a 2-event in vivo rat model by Kelher, Marguerite R., Masuno, Tomhiko, Moore, Ernest E., Damle, Sagar, Meng, Xianzhong, Song, Yong, Liang, Xiayuan, Niedzinski, Jerry, Geier, Steven S., Khan, Samina Y., Gamboni-Robertson, Fabia, Silliman, Christopher C.

“…Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion death. We hypothesize that TRALI requires 2 events: (1) the clinical…”
Get full text

Donor antibodies to HNA-3a implicated in TRALI reactions prime neutrophils and cause PMN-mediated damage to human pulmonary microvascular endothelial cells in a two-event in vitro model by Silliman, Christopher C., Curtis, Brian R., Kopko, Patricia M., Khan, Samina Y., Kelher, Marguerite R., Schuller, Randy M., Sannoh, Baindu, Ambruso, Daniel R.

“…Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related mortality. Antibodies to HNA-3a are commonly implicated in TRALI. We…”
Get full text

Hypertonic Saline Inhibits Arachidonic Acid Priming of the Human Neutrophil Oxidase by Lee, Luis, M.D, Kelher, Marguerite R., M.S, Moore, Ernest E., M.D, Banerjee, Anirban, Ph.D, Silliman, Christopher C., M.D., Ph.D

“…Background Arachidonic acid (AA, and its leukotriene derivatives, e.g., LTB4 ) is an inflammatory mediator in post-shock mesenteric lymph that appears to act…”
Get full text

Elucidating the molecular mechanisms of fibrinolytic shutdown after severe injury: The role of thrombin-activatable fibrinolysis inhibitor by Coleman, Julia R., Moore, Ernest E., Kelher, Marguerite R., Jones, Kenneth, Cohen, Mitchell J., Banerjee, Anirban, Silliman, Christopher C.

“…The mechanisms underlying trauma-induced coagulopathy remain elusive. Hyperfibrinolysis has been linked to increased plasminogen activation and antiprotease…”
Get full text

Bradykinin release following trauma and hemorrhagic shock causes pulmonary alveolar leak in a rodent model by Eitel, Andrew, Moore, Ernest E., Kelher, Marguerite R., Cohen, Mitchell J., Kissau, Daniel, Hadley, Jamie B., Debot, Margaret, Banerjee, Anirban, Silliman, Christopher C.

“…Hemorrhage accounts for 40% of the preventable death following severe injury. Activation of systemic coagulation produces bradykinin (BK), which may cause leak…”
Get full text

Losing the forest for the trees: The complexities of fibrinolysis will never be explained with one variable alone by Coleman, Julia R, Moore, Ernest E, Kelher, Marguerite R, Jones, Kenneth, Cohen, Mitchell J, Banerjee, Anirban, Silliman, Christopher C

Get full text

Female platelets have distinct functional activity compared with male platelets: Implications in transfusion practice and treatment of trauma-induced coagulopathy by Coleman, Julia R, Moore, Ernest E, Kelher, Marguerite R, Samuels, Jason M, Cohen, Mitchell J, Sauaia, Angela, Banerjee, Anirban, Silliman, Christopher C, Peltz, Erik D

“…Females are hypercoagulable and have survival benefit in trauma-induced coagulopathy (TIC). The mechanism for this sex-specific hypercoagulability is unknown…”
Get full text

Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS by Nunns, Geoffrey R., Vigneshwar, Navin, Kelher, Marguerite R., Stettler, Gregory R., Gera, Lajos, Reisz, Julie A., D’Alessandro, Angelo, Ryon, Joshua, Hansen, Kirk C., Gamboni, Fabia, Moore, Ernest E., Peltz, Erik D., Cohen, Mitchell J., Jones, Kenneth L., Sauaia, Angela, Liang, Xiayuan, Banerjee, Anirban, Ghasabyan, Arsen, Chandler, James G., Rodawig, Sophia, Jones, Carter, Eitel, Andrew, Hom, Patrick, Silliman, Christopher C.

“…OBJECTIVES:Identify the metabolites that are increased in the plasma of severely injured patients that developed ARDS versus severely injured patients that did…”
Get full text

A pilot study of the metabolic profiles of apheresis platelets modified by donor age and sex and in vitro short‐term incubation with sex hormones by Hadley, Jamie B., Kelher, Marguerite R., D'Alessandro, Angelo, Gamboni, Fabia, Hansen, Kirk, Coleman, Julia, Jones, Kenneth, Cohen, Mitchell, Moore, Ernest E., Banerjee, Anirban, Silliman, Christopher C.

“…Background Platelets are part of innate immunity and comprise the cellular portion of hemostasis. Platelets express sex hormone receptors on their plasma…”
Get full text

Identification of lipids that accumulate during the routine storage of prestorage leukoreduced red blood cells and cause acute lung injury by Silliman, Christopher C., Moore, Ernest E., Kelher, Marguerite R., Khan, Samina Y., Gellar, Lauren, Elzi, David J.

“…BACKGROUND: Lipids accumulate during the storage of red blood cells (RBCs), prime neutrophils (PMNs), and have been implicated in transfusion‐related acute…”
Get full text

Hormones, age, and sex affect platelet responsiveness in vitro by Hadley, Jamie B., Kelher, Marguerite R., Coleman, Julia R., Kelly, Kathleen K., Dumont, Larry J., Esparza, Orlando, Banerjee, Anirban, Cohen, Mitchell J., Jones, Kenneth, Silliman, Christopher C.

“…Background Female sex confers a survival advantage following severe injury in the setting of trauma‐induced coagulopathy, with female platelets having…”
Get full text

Antibodies to major histocompatibility complex class II antigens directly prime neutrophils and cause acute lung injury in a two-event in vivo rat model by Kelher, Marguerite R., Banerjee, Anirban, Gamboni, Fabia, Anderson, Cameron, Silliman, Christopher C.

“…BACKGROUND Transfusion‐related acute lung injury (TRALI) is a significant cause of mortality, especially after transfusions containing antibodies to major…”
Get full text

BLOOD TYPE O IS A RISK FACTOR FOR HYPERFIBRINOLYSIS AND MASSIVE TRANSFUSION AFTER SEVERE INJURY by DeBot, Margot, Eitel, Andrew P., Moore, Ernest E., Sauaia, Angela, Lutz, Patrick, Schaid, Terry R., Hadley, Jamie B., Kissau, Daniel J., Cohen, Mitchell J., Kelher, Marguerite R., Silliman, Christopher C.

“…Background: Blood type O is the most common blood type and has lower von Willebrand factor (vWF) levels (25%-35% lower than non-O blood types). von Willebrand…”
Get full text

A proposed clinical coagulation score for research in trauma-induced coagulopathy by Eitel, Andrew P., Moore, Ernest E., Sauaia, Angela, Kelher, Marguerite R., Vigneshwar, Navin G., Bartley, Matthew G., Hadley, Jamie B., Burlew, Clay C., Campion, Eric M., Fox, Charles J., Lawless, Ryan A., Pieracci, Frederic M., Platnick, Kenneth B., Moore, Hunter B., Cohen, Mitchell J., Silliman, Christopher C.

“…Trauma-induced coagulopathy (TIC) has been the subject of intense study for greater than a century, and it is associated with high morbidity and mortality. The…”
Get full text

The α-globin chain of hemoglobin potentiates tissue plasminogen activator induced hyperfibrinolysis in vitro by Morton, Alexander P., Hadley, Jamie B., Ghasabyan, Arsen, Kelher, Marguerite R., Moore, Ernest E., Bevers, Shaun, Dzieciatkowska, Monika, Hansen, Kirk C., Cohen, Mitchell S., Banerjee, Anirban, Silliman, Christopher C.

“…Severe injury predisposes patients to trauma-induced coagulopathy, which may be subdivided by the state of fibrinolysis. Systemic hyperfibrinolysis (HF) occurs…”
Get full text

PAS‐C platelets contain less plasma protein, lower anti‐A and anti‐B titers, and decreased HLA antibody specificities compared to plasma platelets by Weisberg, Stuart P., Shaz, Beth H., Tumer, Gizem, Silliman, Chris C., Kelher, Marguerite R., Cohn, Claudia S.

“…BACKGROUND Platelets (PLTs) collected and stored in PLT additive solution Intersol (PAS‐C) are presumed to reduce recipient exposure to donor plasma…”
Get full text

Experimental prestorage filtration removes antibodies and decreases lipids in RBC supernatants mitigating TRALI in vivo by Silliman, Christopher C., Kelher, Marguerite R., Khan, Samina Y., LaSarre, Monica, West, F. Bernadette, Land, Kevin J., Mish, Barbara, Ceriano, Linda, Sowemimo-Coker, Samuel

“…Transfusion-related acute lung injury (TRALI) remains a significant cause of transfusion-related mortality with red cell transfusion. We hypothesize that…”
Get full text

Thrombin stimulates increased plasminogen activator inhibitor-1 release from liver compared to lung endothelium by Huebner, Benjamin R., Moore, Ernest E., Moore, Hunter B., Gonzalez, Eduardo, Kelher, Marguerite R., Sauaia, Angela, Banerjee, Anirban, Silliman, Christopher C.

“…Plasminogen activator inhibitor-1 (PAI-1) is a major regulator of the fibrinolytic system, covalently binding to tissue plasminogen activator and blocking its…”
Get full text