Search Results - "Kelber, Jonathan A"

Role of connexins in metastatic breast cancer and melanoma brain colonization by Stoletov, Konstantin, Strnadel, Jan, Zardouzian, Erin, Momiyama, Masashi, Park, Frederick D, Kelber, Jonathan A, Pizzo, Donald P, Hoffman, Robert, VandenBerg, Scott R, Klemke, Richard L

“…Breast cancer and melanoma cells commonly metastasize to the brain using homing mechanisms that are poorly understood. Cancer patients with brain metastases…”
Get full text

A hypusine-eIF5A-PEAK1 switch regulates the pathogenesis of pancreatic cancer by Fujimura, Ken, Wright, Tracy, Strnadel, Jan, Kaushal, Sharmeela, Metildi, Cristina, Lowy, Andrew M, Bouvet, Michael, Kelber, Jonathan A, Klemke, Richard L

“…Deregulation of protein synthesis is a hallmark of cancer cell proliferation, survival, and metastatic progression. eIF5A1 and its highly related isoform…”
Get full text

Targeting SMAD-Dependent Signaling: Considerations in Epithelial and Mesenchymal Solid Tumors by Runa, Farhana, Ortiz-Soto, Gabriela, de Barros, Natan Roberto, Kelber, Jonathan A

“…SMADs are the canonical intracellular effector proteins of the TGF-β (transforming growth factor-β). SMADs translocate from plasma membrane receptors to the…”
Get full text

Aqueous humor TGFβ and fibrillin-1 in Tsk mice reveal clues to POAG pathogenesis by Tan, James C., Ko, MinHee K., Woo, Jeong-Im, Lu, Kenneth L., Kelber, Jonathan A.

“…Aqueous humor (AH) and blood levels of transforming growth factor β (TGFβ) are elevated in idiopathic primary open angle glaucoma (POAG) representing a disease…”
Get full text

PEAK1 Acts as a Molecular Switch to Regulate Context-Dependent TGFβ Responses in Breast Cancer by Agajanian, Megan, Campeau, Anaamika, Hoover, Malachia, Hou, Alexander, Brambilla, Daniel, Kim, Sa La, Klemke, Richard L, Kelber, Jonathan A

“…Transforming Growth Factor β (TGFβ) has dual functions as both a tumor suppressor and a promoter of cancer progression within the tumor microenvironment, but…”
Get full text

Fibrillin-1 mutant mouse captures defining features of human primary open glaucoma including anomalous aqueous humor TGF beta-2 by Ko, MinHee K., Woo, Jeong-Im, Gonzalez, Jose M., Kim, Gayeoun, Sakai, Lynn, Peti-Peterdi, Janos, Kelber, Jonathan A., Hong, Young-Kwon, Tan, James C.

“…Primary open angle glaucoma (POAG) features an optic neuropathy, elevated aqueous humor (AH) TGFβ2, and major risk factors of central corneal thickness (CCT),…”
Get full text

GRP78 and Cripto Form a Complex at the Cell Surface and Collaborate To Inhibit Transforming Growth Factor β Signaling and Enhance Cell Growth by Shani, Gidi, Fischer, Wolfgang H., Justice, Nicholas J., Kelber, Jonathan A., Vale, Wylie, Gray, Peter C.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression by Wang, Yingchun, Kelber, Jonathan A, Tran Cao, Hop S, Cantin, Greg T, Lin, Rui, Wang, Wei, Kaushal, Sharmeela, Bristow, Jeanne M, Edgington, Thomas S, Hoffman, Robert M, Bouvet, Michael, Yates, 3rd, John R, Klemke, Richard L

“…Regulation of the actin-myosin cytoskeleton plays a central role in cell migration and cancer progression. Here, we report the discovery of a…”
Get full text

CRIPTO/GRP78 Signaling Maintains Fetal and Adult Mammary Stem Cells Ex Vivo by Spike, Benjamin T., Kelber, Jonathan A., Booker, Evan, Kalathur, Madhuri, Rodewald, Rose, Lipianskaya, Julia, La, Justin, He, Marielle, Wright, Tracy, Klemke, Richard, Wahl, Geoffrey M., Gray, Peter C.

“…Little is known about the extracellular signaling factors that govern mammary stem cell behavior. Here, we identify CRIPTO and its cell-surface receptor GRP78…”
Get full text

Editorial: Mechanisms of microenvironment governed plasticity and progression in solid tumors by Kelber, Jonathan A, Iwanicki, Marcin, Kruithof-de Julio, Marianna, Spike, Benjamin T, Martínez-Montemayor, Michelle M

Get full text

A novel method for RNA extraction from FFPE samples reveals significant differences in biomarker expression between orthotopic and subcutaneous pancreatic cancer patient-derived xenografts by Hoover, Malachia, Adamian, Yvess, Brown, Mark, Maawy, Ali, Chang, Alexander, Lee, Jacqueline, Gharibi, Armen, Katz, Matthew H, Fleming, Jason, Hoffman, Robert M, Bouvet, Michael, Doebler, Robert, Kelber, Jonathan A

“…Next-generation sequencing (NGS) can identify and validate new biomarkers of cancer onset, progression and therapy resistance. Substantial archives of…”
Get full text

Designer TGFβ superfamily ligands with diversified functionality by Allendorph, George P, Read, Jessica D, Kawakami, Yasuhiko, Kelber, Jonathan A, Isaacs, Michael J, Choe, Senyon

“…Transforming Growth Factor--beta (TGFβ) superfamily ligands, including Activins, Growth and Differentiation Factors (GDFs), and Bone Morphogenetic Proteins…”
Get full text

Cripto Is a Noncompetitive Activin Antagonist That Forms Analogous Signaling Complexes with Activin and Nodal by Kelber, Jonathan A., Shani, Gidi, Booker, Evan C., Vale, Wylie W., Gray, Peter C.

“…Cripto plays critical roles during embryogenesis and has been implicated in promoting the growth and spread of tumors. Cripto is required for signaling by…”
Get full text

Identification of a PEAK1/ZEB1 signaling axis during TGFβ/fibronectin-induced EMT in breast cancer by Agajanian, Megan, Runa, Farhana, Kelber, Jonathan A.

“…Transforming Growth Factor beta (TGFβ) is the archetypal member of the TGFβ superfamily of ligands and has pleiotropic functions during normal development,…”
Get full text

Multidimensional screening of pancreatic cancer spheroids reveals vulnerabilities in mitotic and cell-matrix adhesion signaling that associate with metastatic progression and decreased patient survival by Aquino, Albert-Fred, Runa, Farhana, Shoma, Jannatul F., Todd, Audrey, Wallace, Matthew, de Barros, Natan Roberto, Kelber, Jonathan A.

“…Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy, with a median survival of less than 12 months and a 5-year survival of less than…”
Get full text

ITGA1 is a pre-malignant biomarker that promotes therapy resistance and metastatic potential in pancreatic cancer by Gharibi, Armen, La Kim, Sa, Molnar, Justin, Brambilla, Daniel, Adamian, Yvess, Hoover, Malachia, Hong, Julie, Lin, Joy, Wolfenden, Laurelin, Kelber, Jonathan A.

“…Pancreatic ductal adenocarcinoma (PDAC) has single-digit 5-year survival rates at <7%. There is a dire need to improve pre-malignant detection methods and…”
Get full text

Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness by Soman, Pranav, Kelber, Jonathan A, Lee, Jin Woo, Wright, Tracy N, Vecchio, Kenneth S, Klemke, Richard L, Chen, Shaochen

“…Abstract Our current understanding of 3-dimensional (3D) cell migration is primarily based on results from fibrous scaffolds with randomly organized internal…”
Get full text

A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers by Hamalian, Sarkis, Güth, Robert, Runa, Farhana, Sanchez, Francesca, Vickers, Eric, Agajanian, Megan, Molnar, Justin, Nguyen, Tuan, Gamez, Joshua, Humphries, Jonathan D., Nayak, Anupma, Humphries, Martin J., Tchou, Julia, Zervantonakis, Ioannis K., Kelber, Jonathan A.

“…Intercellular mechanisms by which the stromal microenvironment contributes to solid tumor progression and targeted therapy resistance remain poorly understood,…”
Get full text

Cell surface GRP78 promotes stemness in normal and neoplastic cells by Conner, Clay, Lager, Tyson W., Guldner, Ian H., Wu, Min-Zu, Hishida, Yuriko, Hishida, Tomoaki, Ruiz, Sergio, Yamasaki, Amanda E., Gilson, Robert C., Belmonte, Juan Carlos Izpisua, Gray, Peter C., Kelber, Jonathan A., Zhang, Siyuan, Panopoulos, Athanasia D.

“…Reliable approaches to identify stem cell mechanisms that mediate aggressive cancer could have great therapeutic value, based on the growing evidence of…”
Get full text

Identification of myosin II as a cripto binding protein and regulator of cripto function in stem cells and tissue regeneration by Hoover, Malachia, Runa, Farhana, Booker, Evan, Diedrich, Jolene K., Duell, Erika, Williams, Blake, Arellano-Garcia, Caroline, Uhlendorf, Toni, La Kim, Sa, Fischer, Wolfgang, Moresco, James, Gray, Peter C., Kelber, Jonathan A.

“…Cripto regulates stem cell function in normal and disease contexts via TGFbeta/activin/nodal, PI3K/Akt, MAPK and Wnt signaling. Still, the molecular mechanisms…”
Get full text