Search Results - "Kelaidonis, Konstantinos"

A Global Review on Short Peptides: Frontiers and Perspectives by Apostolopoulos, Vasso, Bojarska, Joanna, Chai, Tsun-Thai, Elnagdy, Sherif, Kaczmarek, Krzysztof, Matsoukas, John, New, Roger, Parang, Keykavous, Lopez, Octavio Paredes, Parhiz, Hamideh, Perera, Conrad O, Pickholz, Monica, Remko, Milan, Saviano, Michele, Skwarczynski, Mariusz, Tang, Yefeng, Wolf, Wojciech M, Yoshiya, Taku, Zabrocki, Janusz, Zielenkiewicz, Piotr, AlKhazindar, Maha, Barriga, Vanessa, Kelaidonis, Konstantinos, Sarasia, Elham Mousavinezhad, Toth, Istvan

“…Peptides are fragments of proteins that carry out biological functions. They act as signaling entities via all domains of life and interfere with…”
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From Angiotensin II to Cyclic Peptides and Angiotensin Receptor Blockers (ARBs): Perspectives of ARBs in COVID-19 Therapy by Matsoukas, John, Apostolopoulos, Vasso, Zulli, Anthony, Moore, Graham, Kelaidonis, Konstantinos, Moschovou, Kalliopi, Mavromoustakos, Thomas

“…The octapeptide hormone angiotensin II is one of the most studied peptides with the aim of designing and synthesizing non-peptide mimetics for oral…”
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Understanding the Driving Forces That Trigger Mutations in SARS-CoV-2: Mutational Energetics and the Role of Arginine Blockers in COVID-19 Therapy by Ridgway, Harry, Chasapis, Christos T, Kelaidonis, Konstantinos, Ligielli, Irene, Moore, Graham J, Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Mavromoustakos, Thomas, Matsoukas, John M

“…SARS-CoV-2 is a global challenge due to its ability to mutate into variants that spread more rapidly than the wild-type virus. Because the molecular biology of…”
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Actions of Novel Angiotensin Receptor Blocking Drugs, Bisartans, Relevant for COVID-19 Therapy: Biased Agonism at Angiotensin Receptors and the Beneficial Effects of Neprilysin in the Renin Angiotensin System by Moore, Graham J., Ridgway, Harry, Kelaidonis, Konstantinos, Chasapis, Christos T., Ligielli, Irene, Mavromoustakos, Thomas, Bojarska, Joanna, Matsoukas, John M.

“…Angiotensin receptor blockers (ARBs) used in the treatment of hypertension and potentially in SARS-CoV-2 infection exhibit inverse agonist effects at…”
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Structural Features Influencing the Bioactive Conformation of Angiotensin II and Angiotensin A: Relationship between Receptor Desensitization, Addiction, and the Blood-Brain Barrier by Moore, Graham J, Ridway, Harry, Gadanec, Laura Kate, Apostolopoulos, Vasso, Zulli, Anthony, Swiderski, Jordan, Kelaidonis, Konstantinos, Vidali, Veroniki P, Matsoukas, Minos-Timotheos, Chasapis, Christos T, Matsoukas, John M

“…The N-terminal portion of the octapeptide angiotensin II (DRVYIHPF; AngII), a vasopressor peptide that favorably binds to, and activates, AngII type 1 receptor…”
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Molecular Epidemiology of SARS-CoV-2: The Dominant Role of Arginine in Mutations and Infectivity by Ridgway, Harry, Ntallis, Charalampos, Chasapis, Christos T, Kelaidonis, Konstantinos, Matsoukas, Minos-Timotheos, Plotas, Panagiotis, Apostolopoulos, Vasso, Moore, Graham, Tsiodras, Sotirios, Paraskevis, Dimitrios, Mavromoustakos, Thomas, Matsoukas, John M

“…, , , , Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global challenge due to its ability to mutate into variants that spread more rapidly…”
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Computational and Enzymatic Studies of Sartans in SARS-CoV-2 Spike RBD-ACE2 Binding: The Role of Tetrazole and Perspectives as Antihypertensive and COVID-19 Therapeutics by Kelaidonis, Konstantinos, Ligielli, Irene, Letsios, Spiros, Vidali, Veroniki P, Mavromoustakos, Thomas, Vassilaki, Niki, Moore, Graham J, Hoffmann, Weronika, Węgrzyn, Katarzyna, Ridgway, Harry, Chasapis, Christos T, Matsoukas, John M

“…This study is an extension of current research into a novel class of synthetic antihypertensive drugs referred to as "bisartans", which are bis-alkylated…”
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Role of Angiotensin II in Cardiovascular Diseases: Introducing Bisartans as a Novel Therapy for Coronavirus 2019 by Swiderski, Jordan, Gadanec, Laura Kate, Apostolopoulos, Vasso, Moore, Graham J, Kelaidonis, Konstantinos, Matsoukas, John M, Zulli, Anthony

“…Cardiovascular diseases (CVDs) are the main contributors to global morbidity and mortality. Major pathogenic phenotypes of CVDs include the development of…”
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Discovery of a new generation of angiotensin receptor blocking drugs: Receptor mechanisms and in silico binding to enzymes relevant to SARS-CoV-2 by Ridgway, Harry, Moore, Graham J., Mavromoustakos, Thomas, Tsiodras, Sotirios, Ligielli, Irene, Kelaidonis, Konstantinos, Chasapis, Christos T., Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Petty, Russell, Karakasiliotis, Ioannis, Gorgoulis, Vassilis G., Matsoukas, John M.

“…Binding energies and dissociation constants of sartans bound to RBD/ACE2 complex. [Display omitted] The discovery and facile synthesis of a new class of…”
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Receptor Interactions of Angiotensin II and Angiotensin Receptor Blockers—Relevance to COVID-19 by Moore, Graham J., Pires, Jose M., Kelaidonis, Konstantinos, Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Matsoukas, John M.

“…Angiotensin II (Ang II) may contain a charge relay system (CRS) involving Tyr/His/carboxylate, which creates a tyrosinate anion for receptor activation. Energy…”
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Modification of Graphite/SiO2 Film Electrodes with Hybrid Organic–Inorganic Perovskites for the Detection of Vasoconstrictor Bisartan 4-Butyl-Ν,Ν-bis{[2-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}imidazolium Bromide by Papathanidis, Georgios, Ioannou, Anna, Spyrou, Alexandros, Mandrapylia, Aggeliki, Kelaidonis, Konstantinos, Matsoukas, John, Koutselas, Ioannis, Topoglidis, Emmanuel

“…In the present work, a hybrid organic–inorganic semiconductor (HOIS) has been used to modify the surface of a graphite paste/silica (G–SiO2) film electrode on…”
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W254 in furin functions as a molecular gate promoting anti-viral drug binding: Elucidation of putative drug tunneling and docking by non-equilibrium molecular dynamics by Ridgway, Harry, Orbell, John D., Matsoukas, Minos-Timotheos, Kelaidonis, Konstantinos, Moore, Graham J., Tsiodras, Sotiris, Gorgoulis, Vasilis G., Chasapis, Christos T., Apostolopoulos, Vasso, Matsoukas, John M.

“…Furins are serine endoproteases that process precursor proteins into their biologically active forms, and they play essential roles in normal metabolism and…”
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Novel Approaches in the Immunotherapy of Multiple Sclerosis: Cyclization of Myelin Epitope Peptides and Conjugation with Mannan by Matsoukas, John M, Ligielli, Irene, Chasapis, Christos T, Kelaidonis, Konstantinos, Apostolopoulos, Vasso, Mavromoustakos, Thomas

“…Multiple Sclerosis (MS) is a serious autoimmune disease. The patient in an advanced state of the disease has restrained mobility and remains handicapped. It is…”
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Diminazene Aceturate Reduces Angiotensin II Constriction and Interacts with the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus 2 by Matsoukas, John M., Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Kelaidonis, Konstantinos, Ligielli, Irene, Moschovou, Kalliopi, Georgiou, Nikitas, Plotas, Panagiotis, Chasapis, Christos T., Moore, Graham, Ridgway, Harry, Mavromoustakos, Thomas

“…Diminazene aceturate (DIZE) is a putative angiotensin-converting enzyme 2 (ACE2) activator and angiotensin type 1 receptor antagonist (AT1R). Its simple…”
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The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases by Chasapis, Christos T, Kelaidonis, Konstantinos, Ridgway, Harry, Apostolopoulos, Vasso, Matsoukas, John M

“…Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome…”
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Network-Based Prediction of Side Effects of Repurposed Antihypertensive Sartans against COVID-19 via Proteome and Drug-Target Interactomes by Kiouri, Despoina P, Ntallis, Charalampos, Kelaidonis, Konstantinos, Peana, Massimiliano, Tsiodras, Sotirios, Mavromoustakos, Thomas, Giuliani, Alessandro, Ridgway, Harry, Moore, Graham J, Matsoukas, John M, Chasapis, Christos T

“…The potential of targeting the Renin-Angiotensin-Aldosterone System (RAAS) as a treatment for the coronavirus disease 2019 (COVID-19) is currently under…”
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Facile and efficient syntheses of a series of N-benzyl and N-biphenylmethyl substituted imidazole derivatives based on (E)-urocanic acid, as angiotensin II AT1 receptor blockers by Agelis, George, Kelaidonis, Konstantinos, Resvani, Amalia, Kalavrizioti, Dimitra, Androutsou, Maria-Eleni, Plotas, Panagiotis, Vlahakos, Demetrios, Koukoulitsa, Catherine, Tselios, Theodore, Mavromoustakos, Thomas, Matsoukas, John

“…In the present work, a facile and efficient route for the synthesis of a series of N-substituted imidazole derivatives is described. Docking studies have…”
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Solid phase synthesis of a glycopeptide analogue using the acid sensitive 4-methoxybenzhydryl bromide resin by Tselios, Theodore, Kelaidonis, Konstantinos, Resvani, Amalia, Prousalis, Konstantinos, Matsoukas, John, Tsegenidis, Theodore

“…A convenient solid phase synthesis of a Thrombin Receptor Glycopeptide Mimetic analogue namely,…”
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Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies by Ridgway, Harry, Moore, Graham J, Gadanec, Laura Kate, Zulli, Anthony, Apostolopoulos, Vasso, Hoffmann, Weronika, Węgrzyn, Katarzyna, Vassilaki, Niki, Mpekoulis, George, Zouridakis, Marios, Giastas, Petros, Vidali, Veroniki P, Kelaidonis, Konstantinos, Matsoukas, Minos-Timotheos, Dimitriou, Marios, Mavromoustakos, Thomas, Tsiodras, Sotirios, Gorgoulis, Vassilis G, Karakasiliotis, Ioannis, Chasapis, Christos T, Matsoukas, John M

“…Hypertension worsens outcomes in SARS-CoV-2 patients. Sartans, a type of antihypertensive angiotensin receptor blocker-(ARB), reduce COVID-19 morbidity and…”
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Density functional theory and enzyme studies support interactions between angiotensin receptor blockers and angiotensin converting enzyme-2: Relevance to coronavirus 2019 by Apostolopoulos, Vasso, Georgiou, Nikitas, Tzeli, Demeter, Mavromoustakos, Thomas, Moore, Graham J., Kelaidonis, Konstantinos, Matsoukas, Minos-Timotheos, Tsiodras, Sotirios, Swiderski, Jordan, Kate Gadanec, Laura, Zulli, Anthony, Chasapis, Christos T., Matsoukas, John M.

“…[Display omitted] •Introducing “bisartans, novel sartan-like ARBs•ACC519T has promising antiviral abilities by strongly binding to the centre of…”
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