Physiological anticoagulants and activated protein C resistance in childhood stroke

Immunological and functional protein S, protein C and antithrombin III levels and anticoagulant responses to activated protein C were measured in 24 patients with stroke in childhood. No hereditary deficiencies were found. The protein S levels in healthy controls of younger age did not differ from t...

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Bibliographic Details
Published in:	Acta pædiatrica (Oslo) Vol. 85; no. 2; p. 242
Main Authors:	Riikonen, R S, Vahtera, E M, Kekomäki, R M
Format:	Journal Article
Language:	English
Published:	Norway 01-02-1996
Subjects:	Adolescent Antithrombin III - physiology Cerebrovascular Disorders - diagnosis Cerebrovascular Disorders - physiopathology Child Child, Preschool Female Humans Infant, Newborn Male Partial Thromboplastin Time Protein C - physiology Protein S - physiology Protein S Deficiency
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Summary:	Immunological and functional protein S, protein C and antithrombin III levels and anticoagulant responses to activated protein C were measured in 24 patients with stroke in childhood. No hereditary deficiencies were found. The protein S levels in healthy controls of younger age did not differ from the adult levels. For optimal screening of protein S deficiency, measurements using functional as well as immunological assays are recommended. Appropriate criteria for the diagnosis of the deficiencies must be carefully applied if unnecessary anxiety and inappropriate treatment of children are to be avoided.
ISSN:	0803-5253
DOI:	10.1111/j.1651-2227.1996.tb14002.x