Search Results - "Keizer, David"

Insights into dynamic properties of water in lipidic cubic phases by 2D nuclear Overhauser effect (NOE) NMR spectroscopy by Meikle, Thomas G., Keizer, David W., Separovic, Frances, Yao, Shenggen

“…[Display omitted] Two-dimensional NOE (nuclear Overhauser effect) NMR spectroscopy was employed to investigate the dynamic properties of water within lyotropic…”
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Diffusion of Peptides and Small Molecules Encapsulated in Lipidic Cubic Phases by Band-Selective Excitation Short Transient 1 H PGSE NMR by Yao, Shenggen, Meikle, Thomas G, Keizer, David W, Separovic, Frances

“…In model membrane systems, such as lipidic cubic phases (LCPs), H NMR spectra are dominated by resonances from water and lipid molecules. The measurement of…”
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Diffusion of Peptides and Small Molecules Encapsulated in Lipidic Cubic Phases by Band-Selective Excitation Short Transient 1H PGSE NMR by Yao, Shenggen, Meikle, Thomas G., Keizer, David W., Separovic, Frances

“…In model membrane systems, such as lipidic cubic phases (LCPs), 1H NMR spectra are dominated by resonances from water and lipid molecules. The measurement of…”
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NMR techniques for investigating antimicrobial peptides in model membranes and bacterial cells by Sani, Marc-Antoine, Rajput, Sunnia, Keizer, David W., Separovic, Frances

“…•NMR methodologies described for study of antimicrobial peptides in lipid environments.•Review of advances in NMR technology to perform in-cell structural…”
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Utilizing magnetic resonance techniques to study membrane interactions of amyloid peptides by Rajput, Sunnia, Sani, Marc-Antoine, Keizer, David W, Separovic, Frances

“…Alzheimer's disease (AD) is a common neurodegenerative condition that involves the extracellular accumulation of amyloid plaques predominantly consisting of Aβ…”
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The impact of size and charge on the pulmonary pharmacokinetics and immunological response of the lungs to PLGA nanoparticles after intratracheal administration to rats by Haque, Shadabul, Pouton, Colin W., McIntosh, Michelle P., Ascher, David B, Keizer, David W, Whittaker, Michael R., Kaminskas, Lisa M.

“…Polylactide-co-glycolide (PLGA) nanoparticles are one of the most commonly explored biodegradable polymeric drug carriers for inhaled delivery. Despite their…”
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NMR measurement of biomolecular translational and rotational motion for evaluating changes of protein oligomeric state in solution by Yao, Shenggen, Keizer, David W., Babon, Jeffrey J., Separovic, Frances

“…Defining protein oligomeric state and/or its changes in solution is of significant interest for many biophysical studies carried out in vitro, especially when…”
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Physiochemical Characterization and Stability of Lipidic Cubic Phases by Solution NMR by Meikle, Thomas, Keizer, David W, Babon, Jeffrey J, Drummond, Calum J, Separovic, Frances, Conn, Charlotte E, Yao, Shenggen

“…Lipidic inverse bicontinuous cubic phases (LCPs), formed via the spontaneous self-assembly of lipids such as monoolein, have found increasing applications in…”
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Structural insights into BCL2 pro-survival protein interactions with the key autophagy regulator BECN1 following phosphorylation by STK4/MST1 by Lee, Erinna F., Smith, Nicholas A., Soares da Costa, Tatiana P., Meftahi, Nastaran, Yao, Shenggen, Harris, Tiffany J., Tran, Sharon, Pettikiriarachchi, Anne, Perugini, Matthew A., Keizer, David W., Evangelista, Marco, Smith, Brian J., Fairlie, W. Douglas

“…BECN1/Beclin 1 is a critical protein in the initiation of autophagosome formation. Recent studies have shown that phosphorylation of BECN1 by STK4/MST1 at…”
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Chemical Exchange of Hydroxyl Groups in Lipidic Cubic Phases Characterized by NMR by Meikle, Thomas G, Keizer, David W, Babon, Jeffrey J, Drummond, Calum J, Separovic, Frances, Conn, Charlotte E, Yao, Shenggen

“…Proton transportation in proximity to the lipid bilayer membrane surface, where chemical exchange represents a primary pathway, is of significant interest in…”
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In-cell Solid-State NMR Studies of Antimicrobial Peptides by Separovic, Frances, Keizer, David W, Sani, Marc-Antoine

“…Antimicrobial peptides (AMPs) have attracted attention as alternatives to classic antibiotics due to their expected limited pressure on bacterial resistance…”
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Heteronuclear NMR spectroscopy of proteins encapsulated in cubic phase lipids by Meikle, Thomas G., Sethi, Ashish, Keizer, David W., Babon, Jeffrey J., Separovic, Frances, Gooley, Paul R., Conn, Charlotte E., Yao, Shenggen

“…[Display omitted] •Successful encapsulation of 15N-enriched proteins in lipidic cubic phase.•No significant structural changes for LPC encapsulation were…”
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Measuring translational diffusion coefficients of peptides and proteins by PFG-NMR using band-selective RF pulses by Yao, Shenggen, Weber, Daniel K., Separovic, Frances, Keizer, David W.

“…Molecular translational self-diffusion, a measure of diffusive motion, provides information on the effective molecular hydrodynamic radius, as well as…”
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NMR spectroscopy of lipidic cubic phases by Rajput, Sunnia, Yao, Shenggen, Keizer, David W., Sani, Marc-Antoine, Separovic, Frances

“…Lipidic cubic phase (LCP) structures have been used for stabilisation and crystallisation of membrane proteins and show promising properties as drug carriers…”
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A solution NMR view of lipidic cubic phases: Structure, dynamics, and beyond by Meikle, Thomas G, Keizer, David W, Separovic, Frances, Yao, Shenggen

“…•A systematic review for the characterization of lipidic cubic phases (LCPs) by solution NMR is presented.•Various aspects of LCPs readily accessible by…”
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Nuclear Magnetic Resonance Study of the Peptide FRANCESSEPAROVIC by Karas, John A, Keizer, David W, Marc-Antoine Sani

“…As an eminent ambassador of STEM and renowned NMR spectroscopist, Frances Separovic is an internationally famous name, but could it also be a valuable…”
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The BECN1 N-terminal domain is intrinsically disordered by Lee, Erinna F, Perugini, Matthew A, Pettikiriarachchi, Anne, Evangelista, Marco, Keizer, David W, Yao, Shenggen, Fairlie, W Douglas

“…BECN1/Beclin 1 has a critical role in the early stages of autophagosome formation. Recently, structures of its central and C-terminal domains were reported,…”
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Characterisation of the conformational preference and dynamics of the intrinsically disordered N-terminal region of Beclin 1 by NMR spectroscopy by Yao, Shenggen, Lee, Erinna F., Pettikiriarachchi, Anne, Evangelista, Marco, Keizer, David W., Fairlie, W. Douglas

“…Beclin 1 is a 450 amino acid protein that plays critical roles in the early stages of autophagosome formation. We recently reported the successful expression,…”
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Measuring translational diffusion of 15N-enriched biomolecules in complex solutions with a simplified 1H-15N HMQC-filtered BEST sequence by Yao, Shenggen, Meikle, Thomas G., Sethi, Ashish, Separovic, Frances, Babon, Jeffrey J., Keizer, David W.

“…Pulsed-field gradient nuclear magnetic resonance has seen an increase in applications spanning a broad range of disciplines where molecular translational…”
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Nutation frequency modulation on NMR signal of nuclear spins in chemical exchange with solvent water under the BEST conditions by Yao, Shenggen, Keizer, David W.

“…Solvent exchange properties of protein backbone amide protons provide valuable residue‐specific information on protein solvent accessibility, structure…”
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