Search Results - "Keith M. Davies"

Chemistry of the Diazeniumdiolates. 2. Kinetics and Mechanism of Dissociation to Nitric Oxide in Aqueous Solution by Davies, Keith M, Wink, David A, Saavedra, Joseph E, Keefer, Larry K

“…Diazeniumdiolate ions of structure R2N[N(O)NO]- (1) are of pharmacological interest because they spontaneously generate the natural bioregulatory species,…”
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Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family:  In Vitro Antileukemic Activity by Saavedra, Joseph E, Shami, Paul J, Wang, Lai Yi, Davies, Keith M, Booth, Melissa N, Citro, Michael L, Keefer, Larry K

“…We have designed a novel prodrug class that is stable in neutral aqueous media but releases bioactive nitric oxide (NO) on metabolism by esterase…”
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Nitric Oxide-Releasing Polymers Containing the [N(O)NO]- Group by Smith, Daniel J, Chakravarthy, Debashish, Pulfer, Sharon, Simmons, Maia L, Hrabie, Joseph A, Citro, Michael L, Saavedra, Joseph E, Davies, Keith M, Hutsell, Thomas C, Mooradian, Daniel L, Hanson, Stephen R, Keefer, Larry K

“…Ions of structure X[N(O)NO]- display broad-spectrum pharmacological activity that correlates with the rate and extent of their spontaneous, first-order…”
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HNO and NO Release from a Primary Amine-Based Diazeniumdiolate As a Function of pH by Salmon, Debra J, Torres de Holding, Claudia L, Thomas, Lynta, Peterson, Kyle V, Goodman, Gens P, Saavedra, Joseph E, Srinivasan, Aloka, Davies, Keith M, Keefer, Larry K, Miranda, Katrina M

“…The growing evidence that nitroxyl (HNO) has a rich pharmacological potential that differs from that of nitric oxide (NO) has intensified interest in HNO…”
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JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity by Shami, Paul J, Saavedra, Joseph E, Wang, Lai Y, Bonifant, Challice L, Diwan, Bhalchandra A, Singh, Shivendra V, Gu, Yijun, Fox, Stephen D, Buzard, Gregory S, Citro, Michael L, Waterhouse, David J, Davies, Keith M, Ji, Xinhua, Keefer, Larry K

“…We have previously shown that nitric oxide (NO) inhibits growth and induces differentiation and apoptosis in acute myeloid leukemia cells, with the HL-60 human…”
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PABA/NO as an Anticancer Lead:  Analogue Synthesis, Structure Revision, Solution Chemistry, Reactivity toward Glutathione, and in Vitro Activity by Saavedra, Joseph E, Srinivasan, Aloka, Buzard, Gregory S, Davies, Keith M, Waterhouse, David J, Inami, Keiko, Wilde, Thomas C, Citro, Michael L, Cuellar, Matthew, Deschamps, Jeffrey R, Parrish, Damon, Shami, Paul J, Findlay, Victoria J, Townsend, Danyelle M, Tew, Kenneth D, Singh, Shivendra, Jia, Lee, Ji, Xinhua, Keefer, Larry K

“…PABA/NO is a diazeniumdiolate of structure Me2NN(O)NOAr (where Ar is a 5-substituted-2,4-dinitrophenyl ring whose 5-substituent is N-methyl-p-aminobenzoic…”
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"NONOates" (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: convenient nitric oxide dosage forms by Keefer, L K, Nims, R W, Davies, K M, Wink, D A

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Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin by SAAVEDRA, J. E, MOORADIAN, D. L, MOWERY, K. A, SCHOENFISCH, M. H, CITRO, M. L, DAVIES, K. M, MEYERHOFF, M. E, KEEFER, L. K

“…We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they…”
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The Secondary Amine/Nitric Oxide Complex Ion R2N[N(O)NO]- as Nucleophile and Leaving Group in SNAr Reactions by Saavedra, Joseph E, Srinivasan, Aloka, Bonifant, Challice L, Chu, Jingxi, Shanklin, Anna P, Flippen-Anderson, Judith L, Rice, William G, Turpin, Jim A, Davies, Keith M, Keefer, Larry K

“…Ions of structure R2N[N(O)NO]- and their alkylation products have seen increasing use as nitric oxide (NO)-generating agents for biomedical research…”
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Diazeniumdiolate reactivity in model membrane systems by Dinh, Bach T., Price, Stacy E., Majul, Amr, El-Hajj, Mazen, Morozov, Victor, Hrabie, Joseph A., Davies, Keith M.

“…The effect of small unilamellar phospholipid vesicles on the acid-catalyzed dissociation of nitric oxide from diazeniumdiolate ions, R 1R 2N[N(O)NO] −, [ 1: R…”
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Thiol activation of a model O2-aryl diazeniumdiolate prodrug in phospholipid vesicle media by Dinh, Bach T, Zanbrakji, Mohamad N, Dove, Kevin, Price, Stacy E, Peterson, Marit, Davies, Keith M

“…Thiolysis of the model diazeniumdiolate prodrug, O2-(2,4-dinitrophenyl) 1-(N,N-diethylamino)diazen-1-ium-1,2-diolate (DNP-DEA/NO), by glutathione (GSH),…”
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Diazeniumdiolate Ions as Leaving Groups in Anomeric Displacement Reactions:  A Protection−Deprotection Strategy for Ionic Diazeniumdiolates by Showalter, Brett M, Reynolds, Melissa M, Valdez, Carlos A, Saavedra, Joseph E, Davies, Keith M, Klose, John R, Chmurny, Gwendolyn N, Citro, Michael L, Barchi, Joseph J, Merz, Scott I, Meyerhoff, Mark E, Keefer, Larry K

“…Diazeniumdiolate ions [R2N−N(O)N−O-] are of growing interest pharmacologically for their ability to generate up to two molar equivalents of bioactive nitric…”
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Hydrolytic Reactivity Trends among Potential Prodrugs of the O2-Glycosylated Diazeniumdiolate Family. Targeting Nitric Oxide to Macrophages for Antileishmanial Activity by Valdez, Carlos A, Saavedra, Joseph E, Showalter, Brett M, Davies, Keith M, Wilde, Thomas C, Citro, Michael L, Barchi, Joseph J, Deschamps, Jeffrey R, Parrish, Damon, El-Gayar, Stefan, Schleicher, Ulrike, Bogdan, Christian, Keefer, Larry K

“…Glycosylated diazeniumdiolates of structure R2NN(O)NO−R′ (R′ = a saccharide residue) are potential prodrugs of the nitric oxide (NO)-releasing but…”
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Chemistry of the Diazeniumdiolates. 3. Photoreactivity by Srinivasan, Aloka, Kebede, Naod, Saavedra, Joseph E, Nikolaitchik, Alexander V, Brady, Daniel A, Yourd, Emily, Davies, Keith M, Keefer, Larry K, Toscano, John P

“…We have found O2-substituted diazeniumdiolates, compounds of structure R2N−N(O)NOR‘ that are under development for various possible pharmaceutical uses, to be…”
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Chemistry of the Diazeniumdiolates:  Z ⇌ E Isomerism by Wang, Yan-Ni, Bohle, D. Scott, Bonifant, Challice L, Chmurny, Gwendolyn N, Collins, Jack R, Davies, Keith M, Deschamps, Jeffrey, Flippen-Anderson, Judith L, Keefer, Larry K, Klose, John R, Saavedra, Joseph E, Waterhouse, David J, Ivanic, Joseph

“…Here, we explore the chemistry of the previously undocumented E form of diazeniumdiolates having the structure R1R2NN(O)NOR3. Reported crystallographic…”
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Localizing Antithrombotic and Vasodilatory Activity with a Novel, Ultrafast Nitric Oxide Donor by Saavedra, Joseph E, Southan, Garry J, Davies, Keith M, Lundell, Anders, Markou, Chris, Hanson, Stephen R, Adrie, Christophe, Hurford, William E, Zapol, Warren M, Keefer, Larry K

“…Reaction of nitric oxide (NO) with l-proline in methanolic sodium methoxide yields a diazeniumdiolate product, C5H7N3O4Na2·CH3OH (PROLI/NO), that can be…”
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Piperazine as a Linker for Incorporating the Nitric Oxide-Releasing Diazeniumdiolate Group into Other Biomedically Relevant Functional Molecules by Saavedra, Joseph E, Booth, Melissa N, Hrabie, Joseph A, Davies, Keith M, Keefer, Larry K

“…Synthetic procedures have been devised to exploit the bifunctional amine piperazine (pip) as a linker capable of attaching the nitric oxide (NO)-releasing…”
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Effect of hydrophobic structure on the catalysis of nitric oxide release from zwitterionic diazeniumdiolates in surfactant and liposome media by Dinh, Bach, Dove, Kevin, Jappar, Dilara, Hrabie, Joseph A., Davies, Keith M.

“…The effect of phospholipid liposomes and surfactant micelles on the rate of nitric oxide release from zwitterionic diazeniumdiolates, R 1R 2N[N(O)NO] −, with…”
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Unexpected Incorporation of Bromine at a Non-anomeric Position during the Synthesis of an O-Glycosylated Diazeniumdiolate by Saavedra, Joseph E, Davies, Keith M, Barchi, Joseph J, Keefer, Larry K

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Injectable formulation of disodium 1-[2-(carboxylato)pyrrolidin-1-yl]diazen-1-ium-1,2-diolate (PROLI/NO), an ultrafast nitric oxide donor prodrug by Waterhouse, David J, Saavedra, Joseph E, Davies, Keith M, Citro, Michael L, Xu, Xia, Powell, Douglas A, Grimes, George J, Potti, Gopal K, Keefer, Larry K

“…PROLI/NO is an agent of structure XN(O)==NONa (X = L-prolyl) whose 2-s half-life for nitric oxide (NO) release at physiological pH makes it an excellent…”
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