Search Results - "Keita, A. V."
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Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro
Published in Gut (01-01-2008)“…Persistent stress and life events affect the course of ulcerative colitis and irritable bowel syndrome by largely unknown mechanisms. Corticotropin-releasing…”
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Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn's disease
Published in The Journal of pathology (01-06-2008)“…In Crohn's disease (CD), inflammation is driven by luminal commensal micro-organisms; however, mechanisms of early phases of inflammation need further…”
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The intestinal barrier and its regulation by neuroimmune factors
Published in Neurogastroenterology and motility (01-07-2010)“…Background The ability to control uptake across the mucosa and protect from damage of harmful substances from the lumen is defined as intestinal barrier…”
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Vasoactive intestinal polypeptide regulates barrier function via mast cells in human intestinal follicle‐associated epithelium and during stress in rats
Published in Neurogastroenterology and motility (01-06-2013)“…Background Vasoactive intestinal polypeptide (VIP) has been implicated as a regulator of intestinal barrier function and inflammation. Our aim was to elucidate…”
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Differential effects of dietary fibres on colonic barrier function in elderly individuals with gastrointestinal symptoms
Published in Scientific reports (07-09-2018)“…Gastrointestinal problems are common in elderly and often associated with psychological distress and increased levels of corticotrophin-releasing hormone, a…”
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Stress‐induced barrier disruption of rat follicle‐associated epithelium involves corticotropin‐releasing hormone, acetylcholine, substance P, and mast cells
Published in Neurogastroenterology and motility (01-07-2010)“…Background The follicle‐associated epithelium (FAE) is specialized in uptake and sampling of luminal antigens and bacteria. We previously showed that stress…”
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Depressive symptoms in ulcerative colitis and Crohn's disease - differences in improvement at 1 year follow-up
Published in JOURNAL OF CROHNS & COLITIS (2024)“…Background : Mental health (MH) has been reported to be poorer among patients with inflammatory bowel disease (IBD) than general population. However, it is not…”
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Prognostic potential of mucosal proteins in Ulcerative Colitis
Published in JOURNAL OF CROHNS & COLITIS (2024)“…Background : Better prognostic measures for ulcerative colitis (UC) could significantly advance patient care. While the prognostic capacity of circulating…”
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Preclinical protein signatures in blood predict Crohn's disease and Ulcerative colitis several years before the diagnosis
Published in JOURNAL OF CROHNS & COLITIS (2024)“…Background : We aimed to identify protein signatures predictive of a future diagnosis of inflammatory bowel disease (IBD). Methods : We conducted a…”
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Systemic Inflammation in Preclinical Ulcerative Colitis
Published in Gastroenterology (New York, N.Y. 1943) (01-11-2021)“…Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive…”
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A novel diagnostic serum protein signature for paediatric Inflammatory Bowel Disease: A discovery and validation study in two independent inception cohorts
Published in JOURNAL OF CROHNS & COLITIS (2023)Get full text
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Identification and validation of a lipidomic signature as a novel diagnostic biomarker of paediatric Inflammatory Bowel Disease
Published in JOURNAL OF CROHNS & COLITIS (2023)Get full text
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A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts
Published in JOURNAL OF CROHNS & COLITIS (2023)Get full text
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Human skin-resident CD8+ T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a
Published in Immunity (Cambridge, Mass.) (13-06-2023)“…The integrin CD49a marks highly cytotoxic epidermal-tissue-resident memory (TRM) cells, but their differentiation from circulating populations remains poorly…”
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Fecal Biomarkers of Neutrophil and Eosinophil Origin Reflect the Response to Biological Therapy and Corticosteroids in Patients With Inflammatory Bowel Disease
Published in Clinical and translational gastroenterology (2023)“…INTRODUCTIONFecal calprotectin (FC) is a noninvasive tool for examining response to biologics in inflammatory bowel disease (IBD), but its performance in…”
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Translocation of Crohn's disease Escherichia coli across M-cells: contrasting effects of soluble plant fibres and emulsifiers
Published in Gut (01-10-2010)“…Crohn's disease is common in developed nations where the typical diet is low in fibre and high in processed food. Primary lesions overlie Peyer's patches and…”
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Faecal biomarkers for diagnosis and prediction of disease course in treatment‐naïve patients with IBD
Published in Alimentary pharmacology & therapeutics (01-09-2024)“…Summary Background Faecal biomarkers can be used to assess inflammatory bowel disease (IBD). Aim To explore the performance of some promising biomarkers in…”
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Neurotrophic Factors Protect the Intestinal Barrier from Rotavirus Insult in Mice
Published in mBio (01-01-2020)“…Increased intestinal permeability has been proposed as a mechanism of rotavirus-induced diarrhea. Studies with humans and mice have, however, shown that…”
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Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
Published in Nature communications (2024)“…Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel…”
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