Search Results - "Keisuke Ito"

Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal by Ito, Kyoko, Ito, Keisuke

“…Although the stem cells of various tissues remain in the quiescent state to maintain their undifferentiated state, they also undergo cell divisions as…”
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Mitochondrial Contributions to Hematopoietic Stem Cell Aging by Morganti, Claudia, Ito, Keisuke

“…Mitochondrial dysfunction and stem cell exhaustion are two hallmarks of aging. In the hematopoietic system, aging is linked to imbalanced immune response and…”
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Retrograde transport of neurotrophic factor signaling: implications in neuronal development and pathogenesis by Ito, Keisuke, Enomoto, Hideki

“…Neurotrophic factors and their receptors play a central role in neuronal survival. Since neurons have a highly polarized morphology, target-derived…”
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Clinical results of the treatment for sacroiliac joint pain by radiofrequency neurotomy by Ito, Keisuke

“…•RFN allows us to selectively block pain transmission of the nerve fibers.•We were able to achieve sustainable pain relief in 85.1% (57 cases) of the…”
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Arteriolar niches maintain haematopoietic stem cell quiescence by Kunisaki, Yuya, Bruns, Ingmar, Scheiermann, Christoph, Ahmed, Jalal, Pinho, Sandra, Zhang, Dachuan, Mizoguchi, Toshihide, Wei, Qiaozhi, Lucas, Daniel, Ito, Keisuke, Mar, Jessica C., Bergman, Aviv, Frenette, Paul S.

“…Cell cycle quiescence is a critical feature contributing to haematopoietic stem cell (HSC) maintenance. Although various candidate stromal cells have been…”
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A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity by Waki, Toshiyuki, Mameda, Ryo, Nakano, Takuya, Yamada, Sayumi, Terashita, Miho, Ito, Keisuke, Tenma, Natsuki, Li, Yanbing, Fujino, Naoto, Uno, Kaichi, Yamashita, Satoshi, Aoki, Yuichi, Denessiouk, Konstantin, Kawai, Yosuke, Sugawara, Satoko, Saito, Kazuki, Yonekura-Sakakibara, Keiko, Morita, Yasumasa, Hoshino, Atsushi, Takahashi, Seiji, Nakayama, Toru

“…Land plants produce diverse flavonoids for growth, survival, and reproduction. Chalcone synthase is the first committed enzyme of the flavonoid biosynthetic…”
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Leukemia Stem Cells as a Potential Target to Achieve Therapy-Free Remission in Chronic Myeloid Leukemia by Ito, Kyoko, Ito, Keisuke

“…Leukemia stem cells (LSCs, also known as leukemia-initiating cells) not only drive leukemia initiation and progression, but also contribute to drug resistance…”
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Identification of lactic acid bacteria and yeasts, and characterization of food components of sourdoughs used in Japanese bakeries by Fujimoto, Akihito, Ito, Keisuke, Narushima, Noriko, Miyamoto, Takahisa

“…Sourdough is a low-pH, fermented product prepared using lactic acid bacteria and yeast mixed with rye flour, wheat flour, and water. It is used and backslopped…”
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Electron transport chain complex II sustains high mitochondrial membrane potential in hematopoietic stem and progenitor cells by Morganti, Claudia, Bonora, Massimo, Ito, Kyoko, Ito, Keisuke

“…The role of mitochondria in the fate determination of hematopoietic stem and progenitor cells (HSPCs) is not solely limited to the switch from glycolysis to…”
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Enhancement of transcription efficiency by TAR-Tat system increases the functional expression of human olfactory receptors by Ojiro, Ichie, Katsuyama, Hibiki, Kaneko, Ryusei, Ogasawara, Satoshi, Murata, Takeshi, Terada, Yuko, Ito, Keisuke

“…Humans have approximately 400 different olfactory receptors (hORs) and recognize odorants through the repertoire of hOR responses. Although the cell surface…”
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Live visualization of a functional RET‐EGFP chimeric receptor in homozygous knock‐in mice by Sunardi, Mukhamad, Ito, Keisuke, Enomoto, Hideki

“…The GDNF Family Ligands (GFLs) regulate neural development and kidney organogenesis by activating the RET receptor tyrosine kinase. Many RET‐dependent…”
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Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging by Luo, Hanzhi, Mu, Wei-Chieh, Karki, Rajendra, Chiang, Hou-Hsien, Mohrin, Mary, Shin, Jiyung J., Ohkubo, Rika, Ito, Keisuke, Kanneganti, Thirumala-Devi, Chen, Danica

“…Aging-associated defects in hematopoietic stem cells (HSCs) can manifest in their progeny, leading to aberrant activation of the NLRP3 inflammasome in…”
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The Oncogenic MicroRNA miR-22 Targets the TET2 Tumor Suppressor to Promote Hematopoietic Stem Cell Self-Renewal and Transformation by Song, Su Jung, Ito, Keisuke, Ala, Ugo, Kats, Lev, Webster, Kaitlyn, Sun, Su Ming, Jongen-Lavrencic, Mojca, Manova-Todorova, Katia, Teruya-Feldstein, Julie, Avigan, David E., Delwel, Ruud, Pandolfi, Pier Paolo

“…MicroRNAs are frequently deregulated in cancer. Here we show that miR-22 is upregulated in myelodysplastic syndrome (MDS) and leukemia and its aberrant…”
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Physical interactions among flavonoid enzymes in snapdragon and torenia reveal the diversity in the flavonoid metabolon organization of different plant species by Fujino, Naoto, Tenma, Natsuki, Waki, Toshiyuki, Ito, Keisuke, Komatsuzaki, Yuki, Sugiyama, Keigo, Yamazaki, Tatsuya, Yoshida, Saori, Hatayama, Masayoshi, Yamashita, Satoshi, Tanaka, Yoshikazu, Motohashi, Reiko, Denessiouk, Konstantin, Takahashi, Seiji, Nakayama, Toru

“…Summary Flavonoid metabolons (weakly‐bound multi‐enzyme complexes of flavonoid enzymes) are believed to occur in diverse plant species. However, how flavonoid…”
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Frictional melting and thermal fracturing recorded in pelagic sedimentary rocks of the Jurassic accretionary complex, central Japan by Ujiie, Kohtaro, Ito, Keisuke, Nagate, Ayaka, Tabata, Hiroki

“…Deep ocean drilling revealed that shallow seismic slip in subduction zones is localized along weak pelagic clay, resulting in devastating tsunamis. However,…”
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Identification and distinct regulation of three di/tripeptide transporters in Aspergillus oryzae by Tanaka, Mizuki, Ito, Keisuke, Matsuura, Tomomi, Kawarasaki, Yasuaki, Gomi, Katsuya

“…The uptake of di/tripeptides is mediated by the proton-dependent oligopeptide transporter (POT) family. In this study, 3 POT family transporters, designated…”
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Non-catalytic Roles of Tet2 Are Essential to Regulate Hematopoietic Stem and Progenitor Cell Homeostasis by Ito, Kyoko, Lee, Joun, Chrysanthou, Stephanie, Zhao, Yilin, Josephs, Katherine, Sato, Hiroyo, Teruya-Feldstein, Julie, Zheng, Deyou, Dawlaty, Meelad M., Ito, Keisuke

“…The Ten-eleven translocation (TET) enzymes regulate gene expression by promoting DNA demethylation and partnering with chromatin modifiers. TET2, a member of…”
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Human TRPA1 activation by terpenes derived from the essential oil of daidai, Citrus aurantium L. var. daidai Makino by Terada, Yuko, Yamashita, Rie, Ihara, Nozomi, Yamazaki-Ito, Toyomi, Takahashi, Yuma, Masuda, Haruka, Sakuragawa, Satoshi, Ito, Sohei, Ito, Keisuke, Watanabe, Tatsuo

“…Daidai (bitter orange, Citrus aurantium) is characterized by its fresh citrus scent. In Japanese cuisine, its juice is an important ingredient. As tons of…”
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A new screening method for identifying chemosensory receptors responding to agonist by Tsuchiya, Sakura, Terada, Yuko, Matsuyama, Minami, Yamazaki-Ito, Toyomi, Ito, Keisuke

“…ABSTRACT Humans sense taste and smell of various chemical substances through approximately 430 chemosensory receptors. The overall picture of…”
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PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release by Giorgi, Carlotta, Ito, Keisuke, Lin, Hui-Kuan, Santangelo, Clara, Wieckowski, Mariusz R, Lebiedzinska, Magdalena, Bononi, Angela, Bonora, Massimo, Duszynski, Jerzy, Bernardi, Rosa, Rizzuto, Rosario, Tacchetti, Carlo, Pinton, Paolo, Pandolfi, Pier Paolo

“…The promyelocytic leukemia (PML) tumor suppressor is a pleiotropic modulator of apoptosis. However, the molecular basis for such a diverse proapoptotic role is…”
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