Search Results - "Keiser, W."

Unique characteristics of AAV1, 2, and 5 viral entry, intracellular trafficking, and nuclear import define transduction efficiency in HeLa cells by Keiser, Nicholas W, Yan, Ziying, Zhang, Yulong, Lei-Butters, Diana C M, Engelhardt, John F

“…Biological differences between recombinant adeno-associated virus (rAAV) serotypes define their efficiencies in expressing a transgene in a particular target…”
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Distinct transduction difference between adeno-associated virus type 1 and type 6 vectors in human polarized airway epithelia by Yan, Z, Lei-Butters, D C M, Keiser, N W, Engelhardt, J F

“…Of the many biologically isolated adeno-associated virus (AAV) serotypes, AAV1 and AAV6 share the highest degree of sequence homology, with only six different…”
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Chondroitin Sulfate is the Primary Receptor for a Peptide-Modified AAV That Targets Brain Vascular Endothelium In Vivo by Geoghegan, James C, Keiser, Nicholas W, Okulist, Anna, Martins, Inês, Wilson, Matthew S, Davidson, Beverly L

“…Recently, we described a peptide-modified AAV2 vector (AAV-GMN) containing a capsid-displayed peptide that directs in vivo brain vascular targeting and…”
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Infection Is Not Required for Mucoinflammatory Lung Disease in CFTR-Knockout Ferrets by Rosen, Bradley H, Evans, T Idil Apak, Moll, Shashanna R, Gray, Jaimie S, Liang, Bo, Sun, Xingshen, Zhang, Yulong, Jensen-Cody, Chandler W, Swatek, Anthony M, Zhou, Weihong, He, Nan, Rotti, Pavana G, Tyler, Scott R, Keiser, Nicholas W, Anderson, Preston J, Brooks, Leonard, Li, Yalan, Pope, R Marshall, Rajput, Maheen, Hoffman, Eric A, Wang, Kai, Harris, J Kirk, Parekh, Kalpaj R, Gibson-Corley, Katherine N, Engelhardt, John F

“…Classical interpretation of cystic fibrosis (CF) lung disease pathogenesis suggests that infection initiates disease progression, leading to an exuberant…”
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New animal models of cystic fibrosis: what are they teaching us? by Keiser, Nicholas W, Engelhardt, John F

“…PURPOSE OF REVIEWCystic fibrosis is the first human genetic disease to benefit from the directed engineering of three different species of animal models (mice,…”
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A Novel Chimeric Adenoassociated Virus 2/Human Bocavirus 1 Parvovirus Vector Efficiently Transduces Human Airway Epithelia by Yan, Ziying, Keiser, Nicholas W, Song, Yi, Deng, Xuefeng, Cheng, Fang, Qiu, Jianming, Engelhardt, John F

“…Human bocavirus virus-1 (HBoV1), a newly discovered autonomous parvovirus with a 5,500 nt genome, efficiently infects human-polarized airway epithelia (HAE)…”
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Defective innate immunity and hyperinflammation in newborn cystic fibrosis transmembrane conductance regulator-knockout ferret lungs by Keiser, Nicholas W, Birket, Susan E, Evans, Idil A, Tyler, Scott R, Crooke, Adrianne K, Sun, Xingshen, Zhou, Weihong, Nellis, Joseph R, Stroebele, Elizabeth K, Chu, Kengyeh K, Tearney, Guillermo J, Stevens, Mark J, Harris, J Kirk, Rowe, Steven M, Engelhardt, John F

“…Mucociliary clearance (MCC) and submucosal glands are major components of airway innate immunity that have impaired function in cystic fibrosis (CF). Although…”
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Abnormal endocrine pancreas function at birth in cystic fibrosis ferrets by Olivier, Alicia K, Yi, Yaling, Sun, Xingshen, Sui, Hongshu, Liang, Bo, Hu, Shanming, Xie, Weiliang, Fisher, John T, Keiser, Nicholas W, Lei, Diana, Zhou, Weihong, Yan, Ziying, Li, Guiying, Evans, Turan I A, Meyerholz, David K, Wang, Kai, Stewart, Zoe A, Norris, Andrew W, Engelhardt, John F

“…Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it…”
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Lung phenotype of juvenile and adult cystic fibrosis transmembrane conductance regulator-knockout ferrets by Sun, Xingshen, Olivier, Alicia K, Liang, Bo, Yi, Yaling, Sui, Hongshu, Evans, Turan I A, Zhang, Yulong, Zhou, Weihong, Tyler, Scott R, Fisher, John T, Keiser, Nicholas W, Liu, Xiaoming, Yan, Ziying, Song, Yi, Goeken, J Adam, Kinyon, Joann M, Fligg, Danielle, Wang, Xiaoyan, Xie, Weiliang, Lynch, Thomas J, Kaminsky, Paul M, Stewart, Zoe A, Pope, R Marshall, Frana, Timothy, Meyerholz, David K, Parekh, Kalpaj, Engelhardt, John F

“…Chronic bacterial lung infections in cystic fibrosis (CF) are caused by defects in the CF transmembrane conductance regulator chloride channel. Previously, we…”
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Gastrointestinal Pathology in Juvenile and Adult CFTR -Knockout Ferrets by Sun, Xingshen, Olivier, Alicia K, Yi, Yaling, Pope, Christopher E, Hayden, Hillary S, Liang, Bo, Sui, Hongshu, Zhou, Weihong, Hager, Kyle R, Zhang, Yulong, Liu, Xiaoming, Yan, Ziying, Fisher, John T, Keiser, Nicholas W, Song, Yi, Tyler, Scott R, Goeken, J. Adam, Kinyon, Joann M, Radey, Matthew C, Fligg, Danielle, Wang, Xiaoyan, Xie, Weiliang, Lynch, Thomas J, Kaminsky, Paul M, Brittnacher, Mitchell J, Miller, Samuel I, Parekh, Kalpaj, Meyerholz, David K, Hoffman, Lucas R, Frana, Timothy, Stewart, Zoe A, Engelhardt, John F

“…Cystic fibrosis (CF) is a multiorgan disease caused by loss of a functional cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel in many…”
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Southwest Oncology Group phase II trial of concurrent carboplatin, etoposide, and radiation for poor-risk stage III non-small-cell lung cancer by Lau, D H, Crowley, J J, Gandara, D R, Hazuka, M B, Albain, K S, Leigh, B, Fletcher, W S, Lanier, K S, Keiser, W L, Livingston, R B

“…A phase II study was conducted by the Southwest Oncology Group (SWOG) to assess the efficacy and toxicity of concurrent carboplatin, etoposide, and thoracic…”
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Glandular Proteome Identifies Antiprotease Cystatin C as a Critical Modulator of Airway Hydration and Clearance by Evans, T Idil Apak, Joo, Nam Soo, Keiser, Nicholas W, Yan, Ziying, Tyler, Scott R, Xie, Weiliang, Zhang, Yulong, Hsiao, Jordy J, Cho, Hyung-Ju, Wright, Michael E, Wine, Jeffrey J, Engelhardt, John F

“…Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel lead to viscous secretions from submucosal glands that cannot be…”
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Spatial and temporal expression patterns of the choroideremia gene in the mouse retina by Keiser, Nicholas W, Tang, Waixing, Wei, Zhangyong, Bennett, Jean

“…Choroideremia (CHM), an X-linked retinal disease, is caused by mutations affecting the CHM gene. This gene encodes REP-1, which functions in the covalent…”
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Directing Integrin-linked Endocytosis of Recombinant AAV Enhances Productive FAK-dependent Transduction by Kaminsky, Paul M, Keiser, Nicholas W, Yan, Ziying, Lei-Butters, Diana CM, Engelhardt, John F

“…Recombinant adeno-associated virus (rAAV) is a widely used gene therapy vector. Although a wide range of rAAV serotypes can effectively enter most cell types,…”
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Gene delivery to the airway by Keiser, Nicholas W, Engelhardt, John F

“…This unit describes generation of and gene transfer to several commonly used airway models. Isolation and transduction of primary airway epithelial cells are…”
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886. AAV-Mediated Somatic Gene Transfer as an Approach To Delineate Pathogenic Mechanisms in an Autosomal Dominant Blindness Disorder Resembling Age-Related Macular Degeneration (AMD) by Keiser, Nicholas W., Maminishkis, Arvydas, Bennicelli, Jeannette L., Miller, Sheldon S., Bennett, Jean

“…Malattia Leventinese (ML) is an autosomal dominant inherited macular degeneration with a middle-age onset. Phenotypically, the disease closely resembles…”
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Empirical validation of the Marital Satisfaction Inventory: An actuarial approach by Snyder, Douglas K, Wills, Robert M, Keiser, Thomas W

“…Despite the proliferation of self-report measures of marital satisfaction, few satisfy even minimal criteria of reliability and validity. The current study…”
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Schizotype and the Wechsler Digit Span Test by Keiser, T W

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Capecitabine (X) plus irinotecan (XELIRI) as first-line treatment for metastatic colorectal cancer (MCRC): Final safety findings from a phase II trial by Patt, Y. Z., Liebmann, J., Diamandidis, D., Eckhardt, S. G., Javle, M., Justice, G. R., Keiser, W., Lee, F. C., Miller, W., Lin, E.

“…Abstract only…”
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Capecitabine (X) plus irinotecan (XELIRI) as first-line treatment for metastatic colorectal cancer (MCRC): Final safety findings from a phase II trial by Patt, Y. Z., Liebmann, J., Diamandidis, D., Eckhardt, S. G., Javle, M., Justice, G. R., Keiser, W., Lee, F. C., Miller, W., Lin, E.

“…Abstract only…”
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