Search Results - "Keir, J."

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus by Cantó, Carles, Menzies, Keir J., Auwerx, Johan

“…NAD+ has emerged as a vital cofactor that can rewire metabolism, activate sirtuins, and maintain mitochondrial fitness through mechanisms such as the…”
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The role of mitochondria in stem cell fate and aging by Zhang, Hongbo, Menzies, Keir J, Auwerx, Johan

“…The importance of mitochondria in energy metabolism, signal transduction and aging in post-mitotic tissues has been well established. Recently, the crucial…”
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Repairing Mitochondrial Dysfunction in Disease by Sorrentino, Vincenzo, Menzies, Keir J, Auwerx, Johan

“…Mitochondria are essential organelles for many aspects of cellular homeostasis, including energy harvesting through oxidative phosphorylation. Alterations of…”
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Protein acetylation in metabolism — metabolites and cofactors by Menzies, Keir J., Zhang, Hongbo, Katsyuba, Elena, Auwerx, Johan

“…Key Points Acetylation is a key post-translational modification that integrates metabolic flux and physiological processes within cells, including circadian…”
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NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice by Zhang, Hongbo, Ryu, Dongryeol, Wu, Yibo, Gariani, Karim, Wang, Xu, Luan, Peiling, D'Amico, Davide, Ropelle, Eduardo R., Lutolf, Matthias P., Aebersold, Ruedi, Schoonjans, Kristina, Menzies, Keir J., Auwerx, Johan

“…Adult stem cells (SCs) are essential for tissue maintenance and regeneration yet are susceptible to senescence during aging. We demonstrate the importance of…”
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Sirtuin 1-mediated Effects of Exercise and Resveratrol on Mitochondrial Biogenesis by Menzies, Keir J., Singh, Kaustabh, Saleem, Ayesha, Hood, David A.

“…The purpose of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise- and resveratrol (RSV)-induced skeletal muscle mitochondrial biogenesis…”
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Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle by Pirinen, Eija, Cantó, Carles, Jo, Young Suk, Morato, Laia, Zhang, Hongbo, Menzies, Keir J., Williams, Evan G., Mouchiroud, Laurent, Moullan, Norman, Hagberg, Carolina, Li, Wei, Timmers, Silvie, Imhof, Ralph, Verbeek, Jef, Pujol, Aurora, van Loon, Barbara, Viscomi, Carlo, Zeviani, Massimo, Schrauwen, Patrick, Sauve, Anthony A., Schoonjans, Kristina, Auwerx, Johan

“…We previously demonstrated that the deletion of the poly(ADP-ribose)polymerase (Parp)-1 gene in mice enhances oxidative metabolism, thereby protecting against…”
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Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice by Gariani, Karim, Menzies, Keir J., Ryu, Dongryeol, Wegner, Casey J., Wang, Xu, Ropelle, Eduardo R., Moullan, Norman, Zhang, Hongbo, Perino, Alessia, Lemos, Vera, Kim, Bohkyung, Park, Young‐Ki, Piersigilli, Alessandra, Pham, Tho X., Yang, Yue, Ku, Chai Siah, Koo, Sung I., Fomitchova, Anna, Cantó, Carlos, Schoonjans, Kristina, Sauve, Anthony A., Lee, Ji‐Young, Auwerx, Johan

“…With no approved pharmacological treatment, nonalcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease in Western countries…”
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Global community breaks at 60 m on mesophotic coral reefs by Lesser, Michael P., Slattery, Marc, Laverick, Jack H., Macartney, Keir J., Bridge, Tom C., Pandolfi, John

“…Aim Mesophotic coral ecosystems (MCEs) are unique communities that support a high proportion of depth‐endemic species distinct from shallow‐water coral reefs…”
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SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing Hepatic Reverse Cholesterol Transport by Stein, Sokrates, Oosterveer, Maaike H., Mataki, Chikage, Xu, Pan, Lemos, Vera, Havinga, Rick, Dittner, Claudia, Ryu, Dongryeol, Menzies, Keir J., Wang, Xu, Perino, Alessia, Houten, Sander M., Melchior, Frauke, Schoonjans, Kristina

“…Reverse cholesterol transport (RCT) is an antiatherogenic process in which excessive cholesterol from peripheral tissues is transported to the liver and…”
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Placental Mitochondrial Function and Dysfunction in Preeclampsia by Jahan, Fahmida, Vasam, Goutham, Green, Alex E, Bainbridge, Shannon A, Menzies, Keir J

“…The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and…”
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Quantifying sponge communities from shallow to mesophotic depths using orthorectified imagery by Lesser, Michael P., Slattery, Marc, Macartney, Keir J.

“…Mesophotic coral reefs are estimated to represent up to 80% of the total areal coverage for coral reefs worldwide. Quantifying mesophotic coral reef community…”
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Social isolation, loneliness and physical performance in older-adults: fixed effects analyses of a cohort study by Philip, Keir E. J., Polkey, Michael I., Hopkinson, Nicholas S., Steptoe, Andrew, Fancourt, Daisy

“…Isolation and loneliness are related to various aspects of health. Physical performance is a central component of health. However, its relationship with…”
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Correction: Quantifying sponge communities from shallow to mesophotic depths using orthorectified imagery by Lesser, Michael P., Slattery, Marc, Macartney, Keir J.

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NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation by Ryu, Dongryeol, Zhang, Hongbo, Ropelle, Eduardo R, Sorrentino, Vincenzo, Mázala, Davi A G, Mouchiroud, Laurent, Marshall, Philip L, Campbell, Matthew D, Ali, Amir Safi, Knowels, Gary M, Bellemin, Stéphanie, Iyer, Shama R, Wang, Xu, Gariani, Karim, Sauve, Anthony A, Cantó, Carles, Conley, Kevin E, Walter, Ludivine, Lovering, Richard M, Chin, Eva R, Jasmin, Bernard J, Marcinek, David J, Menzies, Keir J, Auwerx, Johan

“…Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of…”
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Sarcopenia and Muscle Aging: A Brief Overview by Dao, Tam, Green, Alexander E, Kim, Yun A, Bae, Sung-Jin, Ha, Ki-Tae, Gariani, Karim, Lee, Mi-Ra, Menzies, Keir J, Ryu, Dongryeol

“…The world is facing the new challenges of an aging population, and understanding the process of aging has therefore become one of the most important global…”
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Proteomics characterization of mitochondrial‐derived vesicles under oxidative stress by Vasam, Goutham, Nadeau, Rachel, Cadete, Virgilio J. J., Lavallée‐Adam, Mathieu, Menzies, Keir J., Burelle, Yan

“…Mitochondria share attributes of vesicular transport with their bacterial ancestors given their ability to form mitochondrial‐derived vesicles (MDVs). MDVs are…”
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Mitochondrial function and apoptotic susceptibility in aging skeletal muscle by Chabi, Béatrice, Ljubicic, Vladimir, Menzies, Keir J., Huang, Julianna H., Saleem, Ayesha, Hood, David A.

“…Summary During aging, skeletal muscle undergoes sarcopenia, a condition characterized by a loss of muscle cell mass and alterations in contractile function…”
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COVID-19 related concerns of people with long-term respiratory conditions: a qualitative study by Philip, Keir E J, Lonergan, Bradley, Cumella, Andrew, Farrington-Douglas, Joe, Laffan, Michael, Hopkinson, Nicholas S

“…The COVID-19 pandemic is having profound psychological impacts on populations globally, with increasing levels of stress, anxiety, and depression being…”
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Connective tissue disease related fibrotic lung disease: high resolution computed tomographic and pulmonary function indices as prognostic determinants by Walsh, Simon L F, Sverzellati, Nicola, Devaraj, Anand, Keir, Gregory J, Wells, Athol U, Hansell, David M

“…To determine high resolution computed tomography (HRCT) patterns and pulmonary function indices which are associated with increased mortality in patients with…”
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