Search Results - "Keipert, Peter E."

An Overview of Two Human Trials of Perfluorocarbon Emulsions in Noncardiac Surgery by Spahn, Donat R, Keipert, Peter E

Get full text

Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease by Keipert, Peter E

“…MP4CO, developed by Sangart Inc. (San Diego, CA), is a pegylated human hemoglobin-based carbon monoxide (CO) delivery agent and oxygen therapeutic that has…”
Get more information

Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: a randomized, double-blind, multicenter study by Olofsson, Christina I, Górecki, Andrzej Z, Dirksen, Ris, Kofranek, Ivo, Majewski, Jacek A, Mazurkiewicz, Tomasz, Jahoda, David, Fagrell, Bengt, Keipert, Peter E, Hardiman, Yun J, Levy, Howard

“…MP4OX (oxygenated polyethylene glycol-modified hemoglobin) is an oxygen therapeutic agent with potential applications in clinical settings where targeted…”
Get full text

A Double-Blind, Randomized, Multicenter Study of MP4OX for Treatment of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty Under Spinal Anesthesia by van der Linden, Philippe, Gazdzik, Tadeusz S., Jahoda, David, Heylen, René J., Skowronski, Jan C., Pellar, David, Kofranek, Ivo, Górecki, Andrzej Z., Fagrell, Bengt, Keipert, Peter E., Hardiman, Yun J., Levy, Howard

“…MP4OX (oxygenated polyethylene glycol-modified hemoglobin) is a novel oxygen therapeutic agent specifically developed to perfuse and oxygenate tissue at risk…”
Get full text

Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death by Keipert, Peter E, Olofsson, Christina, Winslow, Robert M

Get full text

Perflubron emulsion delays blood transfusions in orthopedic surgery by SPAHN, D. R, VAN BREMPT, R, THEILMEIER, G, REIBOLD, J.-P, WELTE, M, HEINZERLING, H, BIRCK, K. M, KEIPERT, P. E, MESSMER, K

Get full text

Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions by Bruegger, Dirk, Kemming, Gregor I, Jacob, Matthias, Meisner, Franz G, Wojtczyk, Christoph J, Packert, Kristian B, Keipert, Peter E, Faithfull, N Simon, Habler, Oliver P, Becker, Bernhard F, Rehm, Markus

“…Metabolic acidosis during hemorrhagic shock is common and conventionally considered to be due to hyperlactatemia. There is increasing awareness, however, that…”
Get full text

Randomized Safety Studies of Intravenous Perflubron Emulsion. I. Effects on Coagulation Function in Healthy Volunteers by Leese, Phillip T., Noveck, Robert J., Shorr, Jolene S., Woods, Catherine M., Flaim, Kathryn E., Keipert, Peter E.

“…Previous perfluorocarbon (PFC) emulsions have been associated with transient adverse events (i.e., platelet activation, decreased platelet count, febrile…”
Get full text

Randomized Safety Studies of Intravenous Perflubron Emulsion. II. Effects on Immune Function in Healthy Volunteers by Noveck, Robert J., Shannon, E. J., Leese, Phillip T., Shorr, Jolene S., Flaim, Kathryn E., Keipert, Peter E., Woods, Catherine M.

“…Particle size distribution is a major determinant of particle clearance by the mononuclear phagocytic system and the potential for concomitant activation of…”
Get full text

Oxygen therapeutics ("blood substitutes") where are they, and what can we expect? by Keipert, Peter E

Get more information

Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests by Ma, Zhongmin, Monk, Terri G, Goodnough, Lawrence T, McClellan, Adrain, Gawryl, Maria, Clark, Terri, Moreira, Paulo, Keipert, Peter E, Scott, Mitchell G

“…Polymerized hemoglobin solutions (Hb-based oxygen carriers; HBOCs) and a second-generation perfluorocarbon (PFC) emulsion (Perflubron) are in clinical trials…”
Get full text

Perflubron emulsion (AF0144) augments harvesting of autologous blood: A phase II study in cardiac surgery by Hill, Steven E., Leone, Bruce J., Faithfull, N.Simon, Flaim, Kathy E., Keipert, Peter E., Newman, Mark F.

“…Objective: To assess tolerance and preliminary efficacy of a perfluorocarbon emulsion (AF0144) used with acute normovolemic hemodilution to reduce allogeneic…”
Get full text

Hemodilution and hyperoxia locally change distribution of regional pulmonary perfusion in dogs by Kleen, M, Habler, O, Hutter, J, Kemming, G, Podtschaske, A, Tiede, M, Welte, M, Keipert, P E, Batra, S, Faithfull, N S, Corso, C, Zwissler, B, Messmer, K

“…In seven anesthetized dogs, the effects of acute normovolemic hemodilution (ANH) to a hematocrit of 20 and 8% and the effects of hyperoxic ventilation (100%…”
Get full text

Safety and Tolerability Of MP4CO: A Dose Escalation Study In Stable Patients With Sickle Cell Disease by Howard, Jo, Thein, Swee Lay, Galacteros, Frederic, Inati, Adlette, Reid, Marvin, Keipert, Peter E., Small, Tania N., Booth, Frank

“…▪ Vaso-occlusive crises (VOC) remain the hallmark of Sickle Cell Disease (SCD) yet to date no agent has been approved to hasten the resolution of an acute…”
Get full text

Evaluation of MP4OX for Prevention of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty with Spinal Anesthesia by Olofsson, Christina I., Górecki, Andrzej Z., Dirksen, Ris, Kofranek, Ivo, Majewski, Jacek A., Mazurkiewicz, Tomasz, Jahoda, David, Fagrell, Bengt, Keipert, Peter E., Hardiman, Yun J., Levy, Howard

Get full text

Hemoglobin-Based Blood Substitutes and Risk of Myocardial Infarction and Death by Levien, Lewis J, Hodgson, Richard E, James, Michael F. M

Get full text

A Double-Blind, Randomized, Multicenter Study of MP40X for Treatment of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty Under Spinal Anesthesia by VAN DER LINDEN, Philippe, GAZDZIK, Tadeusz S, HARDIMAN, Yun J, LEVY, Howard, JAHODA, David, HEYLEN, René J, SKOWRONSKI, Jan C, PELLAR, David, KOFRANEK, Ivo, GORECKI, Andrzej Z, FAGRELL, Bengt, KEIPERT, Peter E

Get full text

Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone by KEMMING, Gregor I, MEISNER, Franz G, FAITHFULL, Simon, HABLER, Oliver P, WOJTCZYK, Christoph J, PACKERT, Kristian B, MINIOR, Thomas, THIEL, Manfred, TILLMANNS, Jochen, MEIER, Jens, BOTTINO, Daniel, KELPERT, Peter E

“…Perfluorocarbon (PFC) emulsions are intravascular oxygen therapeutics that temporarily enhance tissue oxygenation in dilutional anemia. However, PFC emulsions…”
Get full text

Physiological effects of pyridoxylated polyhemoglobin solution as a blood substitute in rats by Keipert, Peter E

Get full text

A Pilot Study of the Effects of a Perflubron Emulsion, AF 0104, on Mixed Venous Oxygen Tension in Anesthetized Surgical Patients by Wahr, Joyce A., Trouwborst, Adrianus, Spence, Richard K., Henny, Christian P., Cernaianu, Aurel C., Graziano, Gregory P., Tremper, Kevin K., Flaim, Kathryn E., Keipert, Peter E., Faithfull, N. Simon, Clymer, Janice J.

“…A pilot study of a perfluorochemical (PFC) emulsion was undertaken to determine whether administration of a perflubron emulsion could result in measurable…”
Get full text