Search Results - "Keinanen, T. A."

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
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Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
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Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis by Merentie, M, Uimari, A, Pietilä, M, Sinervirta, R, Keinänen, T. A, Vepsäläinen, J, Khomutov, A, Grigorenko, N, Herzig, K.-H, Jänne, J, Alhonen, L

“…The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition,…”
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Mechanisms of polyamine catabolism-induced acute pancreatitis by Hyvönen, M T, Merentie, M, Uimari, A, Keinänen, T A, Jänne, J, Alhonen, L

“…Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the…”
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Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
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Analysis of free, mono- and diacetylated polyamines from human urine by LC–MS/MS by Häkkinen, Merja R., Roine, Antti, Auriola, Seppo, Tuokko, Antti, Veskimäe, Erik, Keinänen, Tuomo A., Lehtimäki, Terho, Oksala, Niku, Vepsäläinen, Jouko

“…•LC–MS/MS method was developed and validated to analyze polyamines from urine samples.•The method omits the laborious derivatization steps in the sample…”
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Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M.T, Sinervirta, R, Keinänen, T.A, Fashe, T, Grigorenko, N, Khomutov, A.R, Vepsäläinen, J, Alhonen, L

“…Abstract Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that…”
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Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine by Khomutov, M. A., Hyvönen, M. T., Salikhov, A. I., Chizhov, A. O., Ryzhov, I. M., Kochetkov, S. N., Vepsäläinen, J., Keinänen, T. A., Khomutov, A. R.

“…A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C ‑methylated spermine (Spm) analogue,…”
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Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism by Khomutov, A R, Keinanen, T A, Grigorenko, N A, Hyvonen, M T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A R, Khomutov, M A, Verspalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the…”
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Application of oxime formation in a radiometric assay of aminooxy compounds by Keinänen, T A, Hyvönen, T, Khomutov, A R, Khomutov, R M, Kauppinen, R A, Vepsäläinen, J, Eloranta, T O

“…A radiometric determination of monoaminooxy analogues of naturally occurring polyamines is described in which [2-14C]acetone is employed as reagent. The…”
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Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme by Keĭnanen, T A, Khivonen, T, Vepsalajnen, Ĭ, Alhonen, L, Homutov, A R, Ianne, Iu

“…Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker…”
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New syntheses of α-methyl- and α,α′-dimethylspermine by Grigorenko, N. A., Vepsalainen, J., Jarvinen, A., Keinanen, T. A., Alhonen, L., Janne, J., Khomutov, A. R.

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New oxaanalogues of spermine by Khomutov, A. R., Simonyan, A. R., Vepsalainen, J., Keinanen, T. A., Alhonen, L., Janne, J.

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Novel metabolically stable and functionally active mimetic of spermidine by Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.

“…Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase…”
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Enantioselective synthesis of (R)- and (S)-3-methylspermidines by Khomutov, M. A., Keinanen, T. A., Hyvonen, M. T., Weisell, J., Vepsalainen, J., Alhonen, L., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown enantiomerically pure ( R )- and ( S )-1,8-diamino-3-methyl-4-azaoctane’s (3-MeSpd’s) were synthesized within 11 steps with high overall yields…”
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Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme by Keinanen, T. A., Hyvonen, T., Vepsalainen, J., Alhonen, L., Khomutov, A. R., Janne, J.

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Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. Synthesis and interaction with the enzyme by Keinanen, T. A., Hyvonen, T., Vepsalainen, J., Alhonen, L., Khomutov, A. R., Janne, J.

“…A convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm and Spd was suggested. The use of acetone linker…”
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Chemical activation of SAT1 corrects diet-induced metabolic syndrome by Castoldi, Francesca, Hyvönen, Mervi T., Durand, Sylvère, Aprahamian, Fanny, Sauvat, Allan, Malik, Shoaib A., Baracco, Elisa Elena, Vacchelli, Erika, Opolon, Paule, Signolle, Nicolas, Lefevre, Déborah, Bossut, Noelie, Eisenberg, Tobias, Dammbrueck, Christopher, Pendl, Tobias, Kremer, Margerie, Lachkar, Sylvie, Einer, Claudia, Michalke, Bernhard, Zischka, Hans, Madeo, Frank, Keinänen, Tuomo A., Maiuri, Maria Chiara, Pietrocola, Federico, Kroemer, Guido

“…The pharmacological targeting of polyamine metabolism is currently under the spotlight for its potential in the prevention and treatment of several…”
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Enantioselective Synthesis of (R)- and (S)-3-Methylspermidines by Khomutov, M A, Keinanen, T A, Hyvonen, M T, Weisell, J, Vepsalainen, J, Alhonen, L, Kochetkov, S N, Khomutov, A R

“…Earlier unknown enantiomerically pure (R)- and (S)-1,8-diamino-3-methyl-4-azaoctane's (3-MeSpd's) were synthesized with high overall yields and optical purity…”
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Detection of prostate cancer by an electronic nose: a proof of principle study by Roine, Antti, Veskimäe, Erik, Tuokko, Antti, Kumpulainen, Pekka, Koskimäki, Juha, Keinänen, Tuomo A, Häkkinen, Merja R, Vepsäläinen, Jouko, Paavonen, Timo, Lekkala, Jukka, Lehtimäki, Terho, Tammela, Teuvo L, Oksala, Niku K J

“…We evaluate the ability of an electronic nose to discriminate prostate cancer from benign prostatic hyperplasia using urine headspace, potentially offering a…”
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