Search Results - "Keinänen, Tuomo A"

Unforeseen Possibilities To Investigate the Regulation of Polyamine Metabolism Revealed by Novel C‑Methylated Spermine Derivatives by Khomutov, Maxim, Hyvönen, Mervi T, Simonian, Alina, Formanovsky, Andrey A, Mikhura, Irina V, Chizhov, Alexander O, Kochetkov, Sergey N, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…The biogenic polyamines, spermine (Spm) and spermidine, are organic polycations present in millimolar concentrations in all eukaryotic cells participating in…”
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Detection of prostate cancer by an electronic nose: a proof of principle study by Roine, Antti, Veskimäe, Erik, Tuokko, Antti, Kumpulainen, Pekka, Koskimäki, Juha, Keinänen, Tuomo A, Häkkinen, Merja R, Vepsäläinen, Jouko, Paavonen, Timo, Lekkala, Jukka, Lehtimäki, Terho, Tammela, Teuvo L, Oksala, Niku K J

“…We evaluate the ability of an electronic nose to discriminate prostate cancer from benign prostatic hyperplasia using urine headspace, potentially offering a…”
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Role of Polyamine-Induced Dimerization of Antizyme in Its Cellular Functions by Hyvönen, Mervi T, Smirnova, Olga A, Mitkevich, Vladimir A, Tunitskaya, Vera L, Khomutov, Maxim, Karpov, Dmitry S, Korolev, Sergey P, Häkkinen, Merja R, Pietilä, Marko, Gottikh, Marina B, Vepsäläinen, Jouko, Alhonen, Leena, Makarov, Alexander A, Kochetkov, Sergey N, Wallace, Heather M, Keinänen, Tuomo A, Khomutov, Alex R

“…The polyamines, spermine (Spm) and spermidine (Spd), are important for cell growth and function. Their homeostasis is strictly controlled, and a key…”
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Polyamine Metabolism Is Sensitive to Glycolysis Inhibition in Human Neuroblastoma Cells by Ruiz-Pérez, M. Victoria, Medina, Miguel Ángel, Urdiales, José Luis, Keinänen, Tuomo A., Sánchez-Jiménez, Francisca

“…Polyamines are essential for cell proliferation, and their levels are elevated in many human tumors. The oncogene n-myc is known to potentiate polyamine…”
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Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase by Hyvönen, Mervi T, Keinänen, Tuomo A, Nuraeva, Gulgina K, Yanvarev, Dmitry V, Khomutov, Maxim, Khurs, Elena N, Kochetkov, Sergey N, Vepsäläinen, Jouko, Zhgun, Alexander A, Khomutov, Alex R

“…The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells…”
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Urinary Polyamines as Biomarkers for Ovarian Cancer by Niemi, Riikka Johanna, Roine, Antti N, Häkkinen, Merja R, Kumpulainen, Pekka S, Keinänen, Tuomo A, Vepsäläinen, Jouko J, Lehtimäki, Terho, Oksala, Niku K, Mäenpää, Johanna U

“…Elevated concentrations of polyamines have been found in urine of patients with malignant tumors, including ovarian cancer. Previous research has suffered from…”
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Triethylenetetramine modulates polyamine and energy metabolism and inhibits cancer cell proliferation by Hyvönen, Mervi T, Ucal, Sebahat, Pasanen, Markku, Peräniemi, Sirpa, Weisell, Janne, Khomutov, Maxim, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…Polyamine metabolism is an attractive anticancer drug target, since polyamines are absolutely required for cellular proliferation, and increased levels of…”
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Controlling of N -alkylpolyamine analogue metabolism by selective deuteration by Ucal, Sebahat, Häkkinen, Merja R, Alanne, Aino-Liisa, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Hyvönen, Mervi T

“…Replacing protium with deuterium is an efficient method to modulate drug metabolism. -alkylated polyamine analogues are polyamine antimetabolites with proven…”
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α-Difluoromethylornithine-Induced Cytostasis is Reversed by Exogenous Polyamines, Not by Thymidine Supplementation by Hyvönen, Mervi T., Khomutov, Maxim, Vepsäläinen, Jouko, Khomutov, Alex R., Keinänen, Tuomo A.

“…Polyamine spermidine is essential for the proliferation of eukaryotic cells. Administration of polyamine biosynthesis inhibitor α-difluoromethylornithine…”
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Controlling the regioselectivity and stereospecificity of FAD-dependent polyamine oxidases with the use of amine-attached guide molecules as conformational modulators by Keinänen, Tuomo A, Grigorenko, Nikolay, Khomutov, Alex R, Huang, Qingqiu, Uimari, Anne, Alhonen, Leena, Hyvönen, Mervi T, Vepsäläinen, Jouko

“…Enzymes generally display strict stereospecificity and regioselectivity for their substrates. Here by using FAD-dependent human acetylpolyamine oxidase (APAO),…”
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Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
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Analysis of free, mono- and diacetylated polyamines from human urine by LC–MS/MS by Häkkinen, Merja R., Roine, Antti, Auriola, Seppo, Tuokko, Antti, Veskimäe, Erik, Keinänen, Tuomo A., Lehtimäki, Terho, Oksala, Niku, Vepsäläinen, Jouko

“…•LC–MS/MS method was developed and validated to analyze polyamines from urine samples.•The method omits the laborious derivatization steps in the sample…”
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Tamoxifen metabolite endoxifen interferes with the polyamine pathway in breast cancer by Thomas, T. J., Thomas, Thresia, John, Shali, Hsu, Hui-Chen, Yang, PingAr, Keinänen, Tuomo A., Hyvönen, Mervi T.

“…Tamoxifen is the most widely used drug to treat women with estrogen receptor α (ERα)-positive breast cancer. Endoxifen is recognized as the active metabolite…”
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Enantiomers of 3‑Methylspermidine Selectively Modulate Deoxyhypusine Synthesis and Reveal Important Determinants for Spermidine Transport by Hyvönen, Mervi T, Khomutov, Maxim, Petit, Marine, Weisell, Janne, Kochetkov, Sergey N, Alhonen, Leena, Vepsäläinen, Jouko, Khomutov, Alex R, Keinänen, Tuomo A

“…Eukaryotic translation initiation factor 5A (eIF5A) is essential for cell proliferation, becoming functionally active only after post-translational conversion…”
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Charge deficient analogues of the natural polyamines by Weisell, Janne, Hyvönen, Mervi T, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…Mitochondrial dysfunction, either inherited or acquired, is associated with several diseases in humans. Depending on the cell type and location, cells are…”
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The Use of Novel C-Methylated Spermidine Derivatives To Investigate the Regulation of Polyamine Metabolism by Hyvönen, Mervi T, Keinänen, Tuomo A, Khomutov, Maxim, Simonian, Alina, Weisell, Janne, Kochetkov, Sergey N, Vepsäläinen, Jouko, Alhonen, Leena, Khomutov, Alex R

“…The polyamines are organic polycations present at millimolar concentrations in eukaryotic cells where they participate in the regulation of vital cellular…”
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DNA Condensation by Chiral α-Methylated Polyamine Analogues and Protection of Cellular DNA from Oxidative Damage by Nayvelt, Irina, Hyvönen, Mervi T, Alhonen, Leena, Pandya, Ipsit, Thomas, Thresia, Khomutov, Alex R, Vepsäläinen, Jouko, Patel, Rajesh, Keinänen, Tuomo A, Thomas, T. J

“…Polyamines are essential molecules supporting the structure, conformation, and function of nucleic acids and proteins. We studied stereoisomers of…”
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Synthesis and Biological Characterization of Novel Charge-Deficient Spermine Analogues by Weisell, Janne, Hyvönen, Mervi T, Häkkinen, Merja R, Grigorenko, Nikolay A, Pietilä, Marko, Lampinen, Anita, Kochetkov, Sergey N, Alhonen, Leena, Vepsäläinen, Jouko, Keinänen, Tuomo A, Khomutov, Alex R

“…Biogenic polyamines, spermidine and spermine, are positively charged at physiological pH. They are present in all cells and essential for their growth and…”
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Spermidine is indispensable in differentiation of 3T3‐L1 fibroblasts to adipocytes by Vuohelainen, Susanna, Pirinen, Eija, Cerrada‐Gimenez, Marc, Keinänen, Tuomo A., Uimari, Anne, Pietilä, Marko, Khomutov, Alex R., Jänne, Juhani, Alhonen, Leena

“…Impaired adipogenesis has been shown to predispose to disturbed adipocyte function and development of metabolic abnormalities. Previous studies indicate that…”
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Role of Hypusinated Eukaryotic Translation Initiation Factor 5A in Polyamine Depletion-induced Cytostasis by Hyvönen, Mervi T., Keinänen, Tuomo A., Cerrada-Gimenez, Marc, Sinervirta, Riitta, Grigorenko, Nikolay, Khomutov, Alex R., Vepsäläinen, Jouko, Alhonen, Leena, Jänne, Juhani

“…We have earlier shown that α-methylated spermidine and spermine analogues rescue cells from polyamine depletion-induced growth inhibition and maintain…”
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