Search Results - "Keinänen, T. A"

Hydroxylamine derivatives for regulation of spermine and spermidine metabolism by Khomutov, M. A., Weisell, J., Hyvönen, M., Keinänen, T. A., Vepsäläinen, J., Alhonen, L., Khomutov, A. R., Kochetkov, S. N.

“…The biogenic polyamines spermine, spermidine, and their precursor putrescine are present in micro-to-millimolar concentrations in all cell types and are…”
Get full text

Oxidative stress and inflammation in the pathogenesis of activated polyamine catabolism-induced acute pancreatitis by Merentie, M, Uimari, A, Pietilä, M, Sinervirta, R, Keinänen, T. A, Vepsäläinen, J, Khomutov, A, Grigorenko, N, Herzig, K.-H, Jänne, J, Alhonen, L

“…The markers of oxidative stress and inflammation were studied in acute pancreatitis in transgenic rats exhibiting activated polyamine catabolism. In addition,…”
Get full text

Mechanisms of polyamine catabolism-induced acute pancreatitis by Hyvönen, M T, Merentie, M, Uimari, A, Keinänen, T A, Jänne, J, Alhonen, L

“…Acute pancreatitis is an autodigestive disease, in which the pancreatic tissue is damaged by the digestive enzymes produced by the acinar cells. Among the…”
Get more information

Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of α-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M.T, Sinervirta, R, Keinänen, T.A, Fashe, T, Grigorenko, N, Khomutov, A.R, Vepsäläinen, J, Alhonen, L

“…Abstract Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that…”
Get full text

Synthesis of (3R,10R)- and (3S,10S)-Diastereomers of 3,10-Dimethylspermine by Khomutov, M. A., Hyvönen, M. T., Salikhov, A. I., Chizhov, A. O., Ryzhov, I. M., Kochetkov, S. N., Vepsäläinen, J., Keinänen, T. A., Khomutov, A. R.

“…A simple and practical 10-step synthesis is reported for previously unknown diastereomers of C ‑methylated spermine (Spm) analogue,…”
Get full text

Novel metabolically stable and functionally active mimetic of spermidine by Khomutov, M. A., Hyvönen, M. T., Simonian, A. R., Vepsäläinen, J., Alhonen, L., Kochetkov, S. N., Keinänen, T. A.

“…Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1 -acetyltransferase…”
Get full text

Methylated analogs of spermine and spermidine as tools to investigate cellular functions of polyamines and enzymes of their metabolism by Khomutov, A. R, Keinanen, T. A, Grigorenko, N. A, Hyvonen, M. T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A. R, Khomutov, M. A, Vepsalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine (Spm) and spermidine (Spd) are essential for cell growth. Polyamine analogs are widely used to investigate the enzymes of polyamine…”
Get full text

Stable analogues of coenzyme-substrate complex of spermidine/spermine-N1-acetyltransferase reaction. synthesis, interaction with the enzyme by Keĭnanen, T A, Khivonen, T, Vepsalajnen, Ĭ, Alhonen, L, Homutov, A R, Ianne, Iu

“…Convenient two-step synthesis of conjugates of HS-CoA and D-pantetheine with aminooxy analogues of Spm, Spd and Put was suggested. The use of acetone linker…”
Get more information

Monitoring of the uptake and metabolism of aminooxy analogues of polyamines in cultured cells by high-performance liquid chromatography by Hyvönen, T, Keinänen, T A, Khomutov, A R, Khomutov, R M, Eloranta, T O

“…A high-performance liquid chromatographic method for the determination of polyamines and their aminooxy analogues is described. Oxime derivatization with a…”
Get more information

Spermidine promotes adipogenesis of 3T3-L1 cells by preventing interaction of ANP32 with HuR and PP2A by Hyvönen, Mervi T, Koponen, Taina, Weisell, Janne, Pietilä, Marko, Khomutov, Alex R, Vepsäläinen, Jouko, Alhonen, Leena, Keinänen, Tuomo A

“…We have shown previously that the polyamine spermidine is indispensable for differentiation of 3T3-L1 preadipocytes. In the present study, we examined the…”
Get more information

Analysis of free, mono- and diacetylated polyamines from human urine by LC–MS/MS by Häkkinen, Merja R., Roine, Antti, Auriola, Seppo, Tuokko, Antti, Veskimäe, Erik, Keinänen, Tuomo A., Lehtimäki, Terho, Oksala, Niku, Vepsäläinen, Jouko

“…•LC–MS/MS method was developed and validated to analyze polyamines from urine samples.•The method omits the laborious derivatization steps in the sample…”
Get full text

Aminooxy analogues of spermidine evidence the divergent roles of the charged amino nitrogens in the cellular physiology of spermidine by Hyvönen, T, Keinänen, T A, Khomutov, A R, Khomutov, R M, Eloranta, T O

“…Two recently devised spermidine analogues, N-[2-aminooxyethyl]-1,4-diaminobutane (AOEPU) and 1-aminooxy-3-N-[3-aminopropyl]-aminopropane (APAPA), were used to…”
Get more information

Methylated analogues of spermine and spermidine as tools to investigate cellular functions of polyamines and the enzymes of their metabolism by Khomutov, A R, Keinanen, T A, Grigorenko, N A, Hyvonen, M T, Uimari, A, Pietila, M, Cerrada-Gimenez, M, Simonian, A R, Khomutov, M A, Verspalainen, J, Alhonen, L, Janne, J

“…Biogenic amines spermine and spermidine are essential factors of cellular growth. Polyamine analogues are widely used to investigate and to regulate the…”
Get more information

Acute Pancreatitis Induced by Activated Polyamine Catabolism Is Associated with Coagulopathy: Effects of [alpha]-Methylated Polyamine Analogs on Hemostasis by Hyvönen, M T, Sinervirta, R, Keinänen, T A, Fashe, T, Grigorenko, N, Khomutov, A R, Vepsäläinen, J, Alhonen, L

“…Background/Aims: Polyamines are ubiquitous organic cations essential for cellular proliferation and tissue integrity. We have previously shown that pancreatic…”
Get full text

Derivatives of 1-aminooxy-3-aminopropane as polyamine antimetabolites: stability and effects on BHK21/C13 cells by Keinänen, T A, Hyvönen, T, Pankaskie, M C, Vepsäläinen, J J, Eloranta, T O

“…1- or 3-methylated derivatives and oximes of 1-aminooxy-3-aminopropane (APA) with pyridoxal (PL) and pyridoxal 5'-phosphate (PLP) were synthesized to examine…”
Get more information

Novel metabolically stable functionally-active mimetic of spermidine by Khomutov, M A, Khivonen, M T, Simonian, A R, Vepsäläinen, Ĭ, Alkhonen, L, Kochetkov, S N, Keinänen, T A

“…Earlier unknown 1,8-diamino-3-methyl-4-azaoctane (gamma-MeSpd) was synthesized. The analogue was not a substrate of ether spermine/spermidine…”
Get more information

Application of oxime formation in a radiometric assay of aminooxy compounds by Keinänen, T A, Hyvönen, T, Khomutov, A R, Khomutov, R M, Kauppinen, R A, Vepsäläinen, J, Eloranta, T O

“…A radiometric determination of monoaminooxy analogues of naturally occurring polyamines is described in which [2-14C]acetone is employed as reagent. The…”
Get more information

New syntheses of α-methyl- and α,α′-dimethylspermine by Grigorenko, N. A., Vepsalainen, J., Jarvinen, A., Keinanen, T. A., Alhonen, L., Janne, J., Khomutov, A. R.

Get full text

New oxaanalogues of spermine by Khomutov, A. R., Simonyan, A. R., Vepsalainen, J., Keinanen, T. A., Alhonen, L., Janne, J.

Get full text

Enantioselective synthesis of (R)- and (S)-3-methylspermidines by Khomutov, M. A., Keinanen, T. A., Hyvonen, M. T., Weisell, J., Vepsalainen, J., Alhonen, L., Kochetkov, S. N., Khomutov, A. R.

“…Earlier unknown enantiomerically pure ( R )- and ( S )-1,8-diamino-3-methyl-4-azaoctane’s (3-MeSpd’s) were synthesized within 11 steps with high overall yields…”
Get full text