Search Results - "Keinänen, Kari"

Mitotic spindle disassembly in human cells relies on CRIPT having hierarchical redox signals by Xu, Kehan, Wang, Chunxue, Keinänen, Kari, Li, Hong, Cai, Chunlin

“…ABSTRACT Swift and complete spindle disassembly in late mitosis is essential for cell survival, yet how it happens is largely unknown in mammalian cells. Here…”
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Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome by Achuta, Venkat Swaroop, Möykkynen, Tommi, Peteri, Ulla-Kaisa, Turconi, Giorgio, Rivera, Claudio, Keinänen, Kari, Castrén, Maija L

“…Altered neuronal network formation and function involving dysregulated excitatory and inhibitory circuits are associated with fragile X syndrome (FXS). We…”
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KCC2 Interacts with the Dendritic Cytoskeleton to Promote Spine Development by Li, Hong, Khirug, Stanislav, Cai, Chunlin, Ludwig, Anastasia, Blaesse, Peter, Kolikova, Julia, Afzalov, Ramil, Coleman, Sarah K., Lauri, Sari, Airaksinen, Matti S., Keinänen, Kari, Khiroug, Leonard, Saarma, Mart, Kaila, Kai, Rivera, Claudio

“…The neuron-specific K-Cl cotransporter, KCC2, induces a developmental shift to render GABAergic transmission from depolarizing to hyperpolarizing. Now we…”
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Dysregulated Ca2+-Permeable AMPA Receptor Signaling in Neural Progenitors Modeling Fragile X Syndrome by Danesi, Claudia, Keinänen, Kari, Castrén, Maija L.

“…Fragile X syndrome (FXS) is a neurodevelopmental disorder that represents a common cause of intellectual disability and is a variant of autism spectrum…”
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Aggregation Limits Surface Expression of Homomeric GluA3 Receptors by Coleman, Sarah K., Hou, Ying, Willibald, Marina, Semenov, Artur, Möykkynen, Tommi, Keinänen, Kari

“…AMPA receptors are glutamate-gated cation channels assembled from GluA1–4 subunits and have properties that are strongly dependent on the subunit composition…”
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Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors by von Ossowski, Lotta, Li, Li-Li, Möykkynen, Tommi, Coleman, Sarah K, Courtney, Michael J, Keinänen, Kari

“…Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the…”
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Developmental switch in the kinase dependency of long-term potentiation depends on expression of GluA4 subunit-containing AMPA receptors by Luchkina, Natalia V., Huupponen, Johanna, Clarke, Vernon R. J., Coleman, Sarah K., Keinänen, Kari, Taira, Tomi, Lauri, Sari E.

“…The AMPA-receptor subunit GluA4 is expressed transiently in CA1 pyramidal neurons at the time synaptic connectivity is forming, but its physiological…”
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Molecular mechanisms controlling synaptic recruitment of GluA4 subunit-containing AMPA-receptors critical for functional maturation of CA1 glutamatergic synapses by Luchkina, Natalia V., Coleman, Sarah K., Huupponen, Johanna, Cai, Chunlin, Kivistö, Anna, Taira, Tomi, Keinänen, Kari, Lauri, Sari E.

“…Synaptic recruitment of AMPA receptors (AMPARs) represents a key postsynaptic mechanism driving functional development and maturation of glutamatergic…”
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Autoinactivation of the stargazin-AMPA receptor complex: subunit-dependency and independence from physical dissociation by Semenov, Artur, Möykkynen, Tommi, Coleman, Sarah K, Korpi, Esa R, Keinänen, Kari

“…Agonist responses and channel kinetics of native α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors are modulated by transmembrane…”
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Agonist Occupancy Is Essential for Forward Trafficking of AMPA Receptors by Coleman, Sarah K, Moykkynen, Tommi, Jouppila, Annukka, Koskelainen, Susanna, Rivera, Claudio, Korpi, Esa R, Keinanen, Kari

“…Regulated trafficking of AMPA receptors to cell surface and to synapses is an important determinant of neuronal excitability. In the present study, we have…”
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The Three-dimensional Structure of an Ionotropic Glutamate Receptor Reveals a Dimer-of-dimers Assembly by Tichelaar, Willem, Safferling, Markus, Keinänen, Kari, Stark, Holger, Madden, Dean R.

“…The ionotropic glutamate receptors (iGluRs) represent a major family of ion channels whose quaternary structure has not yet been defined. Here, we present the…”
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Ligand-binding Domain Determines Endoplasmic Reticulum Exit of AMPA Receptors by Coleman, Sarah K., Möykkynen, Tommi, Hinkkuri, Sami, Vaahtera, Lauri, Korpi, Esa R., Pentikäinen, Olli T., Keinänen, Kari

“…AMPA receptors (AMPARs) are tetrameric ion channels that mediate rapid glutamate signaling in neurons and many non-neuronal cell types. Endoplasmic reticulum…”
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Engineered synapse model cell: genetic construction and chemical evaluation for reproducible high-throughput analysis by Migita, Satoshi, Tateishi, Akito, Keinänen, Kari, Haruyama, Tetsuya

“…Bioassay models of neural functions must lend themselves to high-throughput analysis in neural drug discovery. However, smart analysis methods for these…”
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Post-synapse model cell for synaptic glutamate receptor (GluR)-based biosensing: strategy and engineering to maximize ligand-gated ion-flux achieving high signal-to-noise ratio by Tateishi, Akito, Coleman, Sarah K, Migita, Satoshi, Keinänen, Kari, Haruyama, Tetsuya

“…Cell-based biosensing is a "smart" way to obtain efficacy-information on the effect of applied chemical on cellular biological cascade. We have proposed an…”
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Surface Expression of GluR-D AMPA Receptor Is Dependent on an Interaction between Its C-Terminal Domain and a 4.1 Protein by Coleman, Sarah K, Cai, Chunlin, Mottershead, David G, Haapalahti, Jukka-Pekka, Keinanen, Kari

“…Dynamic regulation of the number and activity of AMPA receptors is believed to underlie many forms of synaptic plasticity and is presumably mediated by…”
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Analysis of the potential role of GluA4 carboxyl-terminus in PDZ interactions by Coleman, Sarah K, Cai, Chunlin, Kalkkinen, Nisse, Korpi, Esa R, Keinänen, Kari

“…Specific delivery to synapses of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors with long-tailed subunits is believed to be a key event…”
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Isoform-Specific Early Trafficking of AMPA Receptor Flip and Flop Variants by Coleman, Sarah K, Moykkynen, Tommi, Cai, Chunlin, von Ossowski, Lotta, Kuismanen, Esa, Korpi, Esa R, Keinanen, Kari

“…Flip and flop splice variants of AMPA receptor subunits are expressed in distinct but partly overlapping patterns and impart different desensitization kinetics…”
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Interaction of the RhoA Exchange Factor Net1 with Discs Large Homolog 1 Protects It from Proteasome-mediated Degradation and Potentiates Net1 Activity by Carr, Heather S., Cai, Chunlin, Keinänen, Kari, Frost, Jeffrey A.

“…Net1 is a nuclear Rho guanine nucleotide exchange factor that is specific for the RhoA subfamily of small G proteins. Truncated forms of Net1 are transforming…”
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Crystal structure of the second PDZ domain of SAP97 in complex with a GluR‐A C‐terminal peptide by von Ossowski, Ingemar, Oksanen, Esko, von Ossowski, Lotta, Cai, Chunlin, Sundberg, Maria, Goldman, Adrian, Keinänen, Kari

“…Synaptic targeting of GluR‐A subunit‐containing glutamate receptors involves an interaction with synapse‐associated protein 97 (SAP97). The C‐terminus of…”
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Interaction between SAP97 and PSD-95, Two Maguk Proteins Involved in Synaptic Trafficking of AMPA Receptors by Cai, Chunlin, Li, Hong, Rivera, Claudio, Keinänen, Kari

“…Synapse-associated protein 97 (SAP97) and postsynaptic density 95 (PSD-95) are closely related membrane-associated guanylate kinase homologs (Maguks)…”
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