Search Results - "Keillor, J W"

Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival by Kerr, C, Szmacinski, H, Fisher, M L, Nance, B, Lakowicz, J R, Akbar, A, Keillor, J W, Lok Wong, T, Godoy-Ruiz, R, Toth, E A, Weber, D J, Eckert, R L

“…Type 2 transglutaminase (TG2) is an important cancer stem cell survival protein that exists in open and closed conformations. The major intracellular form is…”
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Correction to: Transamidase site-targeted agents alter the conformation of the transglutaminase cancer stem cell survival protein to reduce GTP binding activity and cancer stem cell survival by Kerr, C., Szmacinski, H., Fisher, M. L., Nance, B., Lakowicz, J. R., Akbar, A., Keillor, J. W., Wong, T. Lok, Godoy-Ruiz, R., Toth, E. A., Weber, D. J., Eckert, R. L.

“…A Correction to this paper has been published: https://doi.org/10.1038/s41388-021-01709-5…”
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Kinetic Studies of Guinea Pig Liver Transglutaminase Reveal a General-Base-Catalyzed Deacylation Mechanism by Leblanc, Anouk, Gravel, Christian, Labelle, Judith, Keillor, Jeffrey W

“…Guinea pig liver transglutaminase (TGase) reacts with 0.1 mM N-Cbz-l-Glu(γ-p-nitrophenyl ester)Gly (5, prepared herein, K M = 0.02 mM) to undergo rapid…”
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Synthesis and evaluation of novel dipeptide-bound 1,2,4-Thiadiazoles as irreversible inhibitors of guinea pig liver transglutaminase by Marrano, Claudio, de Macédo, Pierre, Gagnon, Paul, Lapierre, Danielle, Gravel, Christian, Keillor, Jeffrey W

“…Herein we report the synthesis and evaluation of 14 novel peptides as potential irreversible inactivators of guinea pig liver transglutaminase (TGase). These…”
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Nonlinear Free Energy Relationship in the General-Acid-Catalyzed Acylation of Rat Kidney γ-Glutamyl Transpeptidase by a Series of γ-Glutamyl Anilide Substrate Analogues by Ménard, Annie, Castonguay, Roselyne, Lherbet, Christian, Rivard, Caroline, Roupioz, Yoann, Keillor, Jeffrey W

“…The γ-glutamyl transpeptidase (GGT) purified from rat kidney reacts with a series of eight parasubstituted L-glutamyl γ-anilides, in the presence of Gly−Gly,…”
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Catalysis of Amide Hydrolysis and Formation under Neutral Conditions by a Zwitterionic Imidazolium Thiolate by Keillor, J. W, Neverov, A. A, Brown, R. S

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Attack of zwitterionic ammonium thiolates on a distorted anilide as a model for the acylation of papain by amides. A simple demonstration of a bell-shaped pH/rate profile by Keillor, J. W, Brown, R. S

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A Continuous Spectrophotometric Linked Enzyme Assay for Transglutaminase Activity by Day, Nicolas, Keillor, Jeffrey W.

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Evaluation of novel dipeptide-bound α,β-unsaturated amides and epoxides as irreversible inhibitors of guinea pig liver transglutaminase by Marrano, Claudio, de Macédo, Pierre, Keillor, Jeffrey W.

“…Herein, we report the results of irreversible inhibition of guinea pig liver transglutaminase (TGase) by a series of 24 novel dipeptides containing either an…”
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Reaction of a distorted amide with nucleophilic thiolate-containing zwitterions produced from thiolamines. A model for the acylation step in cysteine proteases and transglutaminases by Keillor, J. W, Brown, R. S

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A Direct Continuous Spectrophotometric Assay for Transglutaminase Activity by de Macédo, Pierre, Marrano, Claudio, Keillor, Jeffrey W.

“…Herein we report the development of a direct and continuous spectrophotometric method for determining transglutaminase (TGase) activity by using…”
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Guinea Pig Liver Transglutaminase: A Modified Purification Procedure Affording Enzyme with Superior Activity in Greater Yield by Leblanc, Anouk, Day, Nicolas, Ménard, Annie, Keillor, Jeffrey W.

“…Tissue transglutaminase purified from guinea pig livers has a very broad substrate specificity in comparison with other members of the transglutaminase family…”
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Phosphorylation of the Sodium−Potassium Adenosinetriphosphatase Proceeds through a Rate-Limiting Conformational Change Followed by Rapid Phosphoryl Transfer by Keillor, Jeffrey W, Jencks, William P

“…The sodium−potassium adenosinetriphosphatase of sheep kidney, preincubated with sodium and magnesium (E·Na3), reacts with 0.01−2.00 mM ATP to form covalent…”
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The Crystal Structure of ATP-bound Phosphofructokinase from Trypanosoma brucei Reveals Conformational Transitions Different from those of Other Phosphofructokinases by McNae, Iain W., Martinez-Oyanedel, José, Keillor, Jeffrey W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.

“…The crystal structure of the ATP-bound form of the tetrameric phosphofructokinase (PFK) from Trypanosoma brucei enables detailed comparisons to be made with…”
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Oxygen-18 exchange accompanying the basic hydrolysis of primary, secondary, and tertiary toluamides. 2. The importance of amine leaving abilities from the anionic tetrahedral intermediate by Slebocka-Tilk, H, Bennet, A. J, Keillor, J. W, Brown, R. S, Guthrie, J. Peter, Jodhan, A

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Inhibition of osteoblast differentiation by a transglutaminase-specific inhibitor targets crosslinking activity of cell surface and extracellular factor XIIIA, but not transglutaminase 2 by Al-Jallad, H.F, Chabot, N, Keillor, J.W, Kaartinen, M.T

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The First Crystal Structure of Phosphofructokinase from a Eukaryote: Trypanosoma brucei by Martinez-Oyanedel, José, McNae, Iain W., Nowicki, Matthew W., Keillor, Jeffrey W., Michels, Paul A.M., Fothergill-Gilmore, Linda A., Walkinshaw, Malcolm D.

“…The crystal structure of the ATP-dependent phosphofructokinase (PFK) from Trypanosoma brucei provides the first detailed description of a eukaryotic PFK, and…”
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Synthesis and Characterization of Dimaleimide Fluorogens Designed for Specific Labeling of Proteins by Girouard, Stéphane, Houle, Marie-Hélène, Grandbois, Alain, Keillor, Jeffrey W, Michnick, Stephen W

“…A series of aromatic compounds were prepared bearing two maleimide groups attached directly to the fluorescent cores. The resulting derivatives do not…”
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Gamma-glutamyl transpeptidase substrate specificity and catalytic mechanism by Keillor, Jeffrey W, Castonguay, Roselyne, Lherbet, Christian

“…The enzyme gamma-glutamyltranspeptidase (GGT) is critical to cellular detoxification and leukotriene biosynthesis processes, as well as amino acid transport in…”
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Kinetic Studies of Rat Kidney γ-Glutamyltranspeptidase Deacylation Reveal a General Base-Catalyzed Mechanism by Castonguay, Roselyne, Lherbet, Christian, Keillor, Jeffrey W

“…The enzyme γ-glutamyltranspeptidase (GGT) is critical to cellular detoxification and leukotriene biosynthesis processes, as well as amino acid transport in…”
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