Search Results - "Keiko FURUKAWA"

Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway by Tajima, Orie, Fujita, Yuki, Ohmi, Yuhsuke, Furukawa, Koichi, Furukawa, Keiko

“…Gangliosides, sialic acid-containing glycosphingolipids, are widely involved in regulations of signal transductions to control cellular functions. It has been…”
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Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice by Yoshihara, Toru, Satake, Hiroyuki, Nishie, Toshikazu, Okino, Nozomu, Hatta, Toshihisa, Otani, Hiroki, Naruse, Chie, Suzuki, Hiroshi, Sugihara, Kazushi, Kamimura, Eikichi, Tokuda, Noriyo, Furukawa, Keiko, Fururkawa, Koichi, Ito, Makoto, Asano, Masahide

“…It is uncertain which β4-galactosyltransferase (β4GalT; gene name, B4galt), β4GalT-5 and/or β4GalT-6, is responsible for the production of lactosylceramide…”
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Lack of GD3 synthase (St8sia1) attenuates malignant properties of gliomas in genetically engineered mouse model by Ohkawa, Yuki, Zhang, Pu, Momota, Hiroyuki, Kato, Akira, Hashimoto, Noboru, Ohmi, Yuhsuke, Bhuiyan, Robiul H., Farhana, Yesmin, Natsume, Atsushi, Wakabayashi, Toshihiko, Furukawa, Keiko, Furukawa, Koichi

“…High expression of gangliosides GD3 and GD2 is observed in human gliomas. The functions of GD3 and GD2 in malignant properties have been reported in glioma…”
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Positive Feedback Loop Between PI3K-Akt-mTORC1 Signaling and the Lipogenic Pathway Boosts Akt Signaling: Induction of the Lipogenic Pathway by a Melanoma Antigen by YAMAUCHI, Yoshio, FURUKAWA, Keiko, HAMAMURA, Kazunori, FURUKAWA, Koichi

“…The lipogenic phenotype is a metabolic hallmark of cancer cells. Sterol regulatory element-binding proteins (SREBP) are key transcriptional factors to regulate…”
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Differential roles of gangliosides in malignant properties of melanomas by Ohmi, Yuhsuke, Kambe, Mariko, Ohkawa, Yuki, Hamamura, Kazunori, Tajima, Orie, Takeuchi, Rika, Furukawa, Koichi, Furukawa, Keiko

“…Ganglioside GD3 is widely expressed in human malignant melanomas, and has been reported to be involved in the increased cell proliferation and invasion. In…”
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New era of research on cancer‐associated glycosphingolipids by Furukawa, Koichi, Ohmi, Yuhsuke, Ohkawa, Yuki, Bhuiyan, Robiul H., Zhang, Pu, Tajima, Orie, Hashimoto, Noboru, Hamamura, Kazunori, Furukawa, Keiko

“…Cancer‐associated glycosphingolipids have been used as markers for diagnosis and targets for immunotherapy of malignant tumors. Recent progress in the analysis…”
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ASC amino acid transporter 2, defined by enzyme‐mediated activation of radical sources, enhances malignancy of GD2‐positive small‐cell lung cancer by Esaki, Nobutoshi, Ohkawa, Yuki, Hashimoto, Noboru, Tsuda, Yuhsuke, Ohmi, Yuhsuke, Bhuiyan, Robiul H., Kotani, Norihiro, Honke, Koichi, Enomoto, Atsushi, Takahashi, Masahide, Furukawa, Keiko, Furukawa, Koichi

“…Ganglioside GD2 is specifically expressed in small‐cell lung cancer (SCLC) cells, leading to enhancement of malignant phenotypes, such as cell proliferation…”
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Signaling domains of cancer-associated glycolipids by Furukawa, Koichi, Ohmi, Yuhsuke, Hamamura, Kazunori, Kondo, Yuji, Ohkawa, Yuki, Kaneko, Kei, Hashimoto, Noboru, Yesmin, Farhana, Bhuiyan, Robiul H., Tajima, Orie, Furukawa, Keiko

“…Immunotherapy of malignant cancers is now becoming one of representative approaches to overcome cancers. To construct strategies for immunotherapy, presence of…”
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Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation by Tian, Songhai, Muneeruddin, Khaja, Choi, Mei Yuk, Tao, Liang, Bhuiyan, Robiul H, Ohmi, Yuhsuke, Furukawa, Keiko, Furukawa, Koichi, Boland, Sebastian, Shaffer, Scott A, Adam, Rosalyn M, Dong, Min

“…Glycosylation is a fundamental modification of proteins and membrane lipids. Toxins that utilize glycans as their receptors have served as powerful tools to…”
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Seizure control by adding on other anti-seizure medication on seizure during levetiracetam administration in patients with glioma-related epilepsy by Hattori, Etsuko Yamamoto, Arakawa, Yoshiki, Mineharu, Yohei, Furukawa, Keiko, Terada, Yukinori, Yamao, Yukihiro, Tanji, Masahiro, Kikuchi, Takayuki, Miyamoto, Susumu

“…Abstract Background Epilepsy is a major symptom in patients with glioma. Levetiracetam (LEV) is recognized as a first-line treatment for glioma-related…”
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Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2 by Iwasawa, Taiji, Zhang, Pu, Ohkawa, Yuki, Momota, Hiroyuki, Wakabayashi, Toshihiko, Ohmi, Yuhsuke, Bhuiyan, Robiul H, Furukawa, Keiko, Furukawa, Koichi

“…Sialic acid-containing glycosphingolipids, gangliosides, are considered as cancer associated antigens in neuro-ectoderm-derived tumors such as melanomas and…”
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Aminoglycosides are efficient reagents to induce readthrough of premature termination codon in mutant B4GALNT1 genes found in families of hereditary spastic paraplegia by Yesmin, Farhana, Bhuiyan, Robiul H, Ohmi, Yuhsuke, Ohkawa, Yuki, Tajima, Orie, Okajima, Tetsuya, Furukawa, Keiko, Furukawa, Koichi

“…The readthrough of premature termination codon (PTC) by ribosome sometimes produces full-length proteins. We previously reported a readthrough of PTC of…”
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A Nationwide Questionnaire Survey on Awake Craniotomy in Japan by KAWATA, Masayoshi, FUKUI, Ayaka, MINEHARU, Yohei, KIKUCHI, Takayuki, YAMAO, Yukihiro, HATTORI, Etsuko YAMAMOTO, SHIRAKI, Atsuko, MIZOTA, Toshiyuki, FURUKAWA, Keiko, MIYAMOTO, Susumu, YONEZAWA, Atsushi, ARAKAWA, Yoshiki

“…The number of awake craniotomies is increasing because of its beneficial features. However, not enough information is available regarding the current status of…”
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Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice by Ohmi, Yuhsuke, Tajima, Orie, Ohkawa, Yuki, Yamauchi, Yoshio, Sugiura, Yasuo, Furukawa, Keiko, Furukawa, Koichi

“…J. Neurochem. (2011) 116, 926-935. ABSTRACT: Gangliosides are considered to be involved in the maintenance and repair of nervous tissues. Recently, novel roles…”
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Lewis y Expressed in Oral Squamous Cell Carcinoma Attenuates Malignant Properties via Down-regulation of EGF Signaling by Hotta, Hiroshi, Hamamura, Kazunori, Shibuya, Hidenobu, Ohmi, Yuhsuke, Furukawa, Keiko, Furukawa, Koichi

“…Lewis y is expressed in oral squamous cell carcinoma (OSCC) cells and tumors. Previously, we reported that Lewis y was not expressed in invasion areas, and…”
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Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3 by Shibuya, Hidenobu, Hamamura, Kazunori, Hotta, Hiroshi, Matsumoto, Yasuyuki, Nishida, Yoshihiro, Hattori, Hisashi, Furukawa, Keiko, Ueda, Minoru, Furukawa, Koichi

“…The expression and implications of gangliosides in human osteosarcomas have not been systematically analyzed. In this study, we showed that gangliosides GD3…”
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Extracellular vesicles released from ganglioside GD2-expressing melanoma cells enhance the malignant properties of GD2-negative melanomas by Yesmin, Farhana, Furukawa, Keiko, Kambe, Mariko, Ohmi, Yuhsuke, Bhuiyan, Robiul Hasan, Hasnat, Mohammad Abul, Mizutani, Momoka, Tajima, Orie, Hashimoto, Noboru, Tsuchida, Akiko, Kaneko, Kei, Furukawa, Koichi

“…Exosomes (small extracellular vesicles: EVs) have attracted increasing attention from basic scientists and clinicians since they play important roles in…”
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Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins by Yesmin, Farhana, Bhuiyan, Robiul H, Ohmi, Yuhsuke, Yamamoto, Satoko, Kaneko, Kei, Ohkawa, Yuki, Zhang, Pu, Hamamura, Kazunori, Cheung, Nai-Kong V, Kotani, Norihiro, Honke, Koichi, Okajima, Tetsuya, Kambe, Mariko, Tajima, Orie, Furukawa, Keiko, Furukawa, Koichi

“…Gangliosides have been considered to modulate cell signals in the microdomain of the cell membrane, lipid/rafts, or glycolipid-enriched microdomain/rafts…”
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Roles of GalNAc-disialyl Lactotetraosyl Antigens in Renal Cancer Cells by Tsuchida, Akiko, Senda, Motohiro, Ito, Akihiro, Saito, Seiichi, Kiso, Makoto, Ando, Takayuki, Harduin-Lepers, Anne, Matsuda, Akio, Furukawa, Keiko, Furukawa, Koichi

“…GalNAc-disialyl Lc4 (GalNAc-DSLc4) was reported as a novel antigen that associated with malignant features of renal cell cancers (RCCs). To clarify roles of…”
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Ganglioside GD3 Enhances Adhesion Signals and Augments Malignant Properties of Melanoma Cells by Recruiting Integrins to Glycolipid-enriched Microdomains by Ohkawa, Yuki, Miyazaki, Sayaka, Hamamura, Kazunori, Kambe, Mariko, Miyata, Maiko, Tajima, Orie, Ohmi, Yuhsuke, Yamauchi, Yoshio, Furukawa, Koichi, Furukawa, Keiko

“…Ganglioside GD3 is widely expressed in human malignant melanoma cell lines and tumors. Previously, we reported that GD3+ cells show stronger tyrosine…”
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