Search Results - "Keighren, Margaret A."

A WDR35-dependent coat protein complex transports ciliary membrane cargo vesicles to cilia by Quidwai, Tooba, Wang, Jiaolong, Hall, Emma A, Petriman, Narcis A, Leng, Weihua, Kiesel, Petra, Wells, Jonathan N, Murphy, Laura C, Keighren, Margaret A, Marsh, Joseph A, Lorentzen, Esben, Pigino, Gaia, Mill, Pleasantine

“…Intraflagellar transport (IFT) is a highly conserved mechanism for motor-driven transport of cargo within cilia, but how this cargo is selectively transported…”
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Reconciling diverse mammalian pigmentation patterns with a fundamental mathematical model by Mort, Richard L., Ross, Robert J. H., Hainey, Kirsten J., Harrison, Olivia J., Keighren, Margaret A., Landini, Gabriel, Baker, Ruth E., Painter, Kevin J., Jackson, Ian J., Yates, Christian A.

“…Bands of colour extending laterally from the dorsal to ventral trunk are a common feature of mouse chimeras. These stripes were originally taken as evidence of…”
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PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins by Hall, Emma A., Nahorski, Michael S., Murray, Lyndsay M., Shaheen, Ranad, Perkins, Emma, Dissanayake, Kosala N., Kristaryanto, Yosua, Jones, Ross A., Vogt, Julie, Rivagorda, Manon, Handley, Mark T., Mali, Girish R., Quidwai, Tooba, Soares, Dinesh C., Keighren, Margaret A., McKie, Lisa, Mort, Richard L., Gammoh, Noor, Garcia-Munoz, Amaya, Davey, Tracey, Vermeren, Matthieu, Walsh, Diana, Budd, Peter, Aligianis, Irene A., Faqeih, Eissa, Quigley, Alan J., Jackson, Ian J., Kulathu, Yogesh, Jackson, Mandy, Ribchester, Richard R., von Kriegsheim, Alex, Alkuraya, Fowzan S., Woods, C. Geoffrey, Maher, Eamonn R., Mill, Pleasantine

“…During neurotransmission, synaptic vesicles undergo multiple rounds of exo-endocytosis, involving recycling and/or degradation of synaptic proteins. While…”
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ZMYND10 functions in a chaperone relay during axonemal dynein assembly by Mali, Girish R, Yeyati, Patricia L, Mizuno, Seiya, Dodd, Daniel O, Tennant, Peter A, Keighren, Margaret A, Zur Lage, Petra, Shoemark, Amelia, Garcia-Munoz, Amaya, Shimada, Atsuko, Takeda, Hiroyuki, Edlich, Frank, Takahashi, Satoru, von Kreigsheim, Alex, Jarman, Andrew P, Mill, Pleasantine

“…Molecular chaperones promote the folding and macromolecular assembly of a diverse set of 'client' proteins. How ubiquitous chaperone machineries direct their…”
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Mouse Idh3a mutations cause retinal degeneration and reduced mitochondrial function by Findlay, Amy S, Carter, Roderick N, Starbuck, Becky, McKie, Lisa, Nováková, Klára, Budd, Peter S, Keighren, Margaret A, Marsh, Joseph A, Cross, Sally H, Simon, Michelle M, Potter, Paul K, Morton, Nicholas M, Jackson, Ian J

“…Isocitrate dehydrogenase (IDH) is an enzyme required for the production of α-ketoglutarate from isocitrate. IDH3 generates the NADH used in the mitochondria…”
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Re-evaluation of the causes of variation among mouse aggregation chimaeras by West, John D, Tang, Pin-Chi, Everett, Clare A, MacKay, Gillian E, Flockhart, Jean H, Keighren, Margaret A

“…The composition of adult mouse aggregation chimaeras is much more variable than X-inactivation mosaics. An early theoretical model proposed that almost all the…”
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Survival of glucose phosphate isomerase null somatic cells and germ cells in adult mouse chimaeras by Keighren, Margaret A, Flockhart, Jean H, West, John D

“…The mouse Gpi1 gene encodes the glycolytic enzyme glucose phosphate isomerase. Homozygous Gpi1(-/-) null mouse embryos die but a previous study showed that…”
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Selection against BALB/c strain cells in mouse chimaeras by Tang, Pin-Chi, MacKay, Gillian E, Flockhart, Jean H, Keighren, Margaret A, Kopakaki, Anna, West, John D

“…It has been shown previously that BALB/c strain embryos tend to contribute poorly to mouse aggregation chimaeras. In the present study we showed that BALB/c…”
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A Cell/Cilia Cycle Biosensor for Single-Cell Kinetics Reveals Persistence of Cilia after G1/S Transition Is a General Property in Cells and Mice by Ford, Matthew J., Yeyati, Patricia L., Mali, Girish R., Keighren, Margaret A., Waddell, Scott H., Mjoseng, Heidi K., Douglas, Adam T., Hall, Emma A., Sakaue-Sawano, Asako, Miyawaki, Atsushi, Meehan, Richard R., Boulter, Luke, Jackson, Ian J., Mill, Pleasantine, Mort, Richard L.

“…The cilia and cell cycles are inextricably linked. Centrioles in the basal body of cilia nucleate the ciliary axoneme and sequester pericentriolar matrix (PCM)…”
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Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2‐mediated recombination in the melanocyte lineage by Wilkinson, Emma L., Brennan, Louise C., Harrison, Olivia J., Crane‐Smith, Zoe, Gautier, Philippe, Keighren, Margaret A., Budd, Peter, Swaminathan, Karthic, Machesky, Laura M., Allinson, Sarah L., Jackson, Ian J., Mort, Richard L.

“…Genetic approaches that allow lineage tracing are essential to our future understanding of melanocytes and melanoma. To date, the approaches used to label…”
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Evaluation of triploid↔diploid and trisomy-3↔diploid mouse chimeras as models for investigating how lineage restriction occurs in confined placental mosaicism by Everett, Clare A, Keighren, Margaret A, Flockhart, Jean H, West, John D

“…Human confined placental mosaicism (CPM), where the placental trophoblast is mosaic for a chromosome abnormality but the fetus is chromosomally normal, can…”
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Comparison of two related lines of tauGFP transgenic mice designed for lineage tracing by Sharp, Linda, Pratt, Thomas, MacKay, Gillian E, Keighren, Margaret A, Flockhart, Jean H, Chandler, Emma J, Price, David J, Mason, John O, West, John D

“…The tauGFP reporter fusion protein is produced nearly ubiquitously by the TgTP6.3 transgene in TP6.3 mice and its localisation to microtubules offers some…”
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Lessons from mouse chimaera experiments with a reiterated transgene marker: revised marker criteria and a review of chimaera markers by Keighren, Margaret A., Flockhart, Jean, Hodson, Benjamin A., Shen, Guan-Yi, Birtley, James R., Notarnicola-Harwood, Antonio, West, John D.

“…Recent reports of a new generation of ubiquitous transgenic chimaera markers prompted us to consider the criteria used to evaluate new chimaera markers and…”
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Evaluation of methods for one‐dimensional spatial analysis of two‐dimensional patterns in mouse chimaeras by Hodson, Benjamin A., Unbekandt, Mathieu, Keighren, Margaret A., Springbett, Anthea, West, John D.

“…The relative extent of cell mixing in tissues of mouse chimaeras or mosaics can be studied by comparing the distributions of the two cell populations in the…”
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Clonal analysis of patterns of growth, stem cell activity, and cell movement during the development and maintenance of the murine corneal epithelium by Collinson, J. Martin, Morris, Lucy, Reid, Alasdair I., Ramaesh, Thaya, Keighren, Margaret A., Flockhart, Jean H., Hill, Robert E., Tan, Seong‐Seng, Ramaesh, Kanna, Dhillon, Baljean, West, John D.

“…Patterns of growth and cell movement in the developing and adult corneal epithelium were investigated by analysing clonal patches of LacZ‐expressing cells in…”
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Murine Submucosal Glands Are Clonally Derived and Show a Cystic Fibrosis Gene-Dependent Distribution Pattern by Borthwick, Duncan W, West, John D, Keighren, Margaret A, Flockhart, Jean H, Innes, Brendan A, Dorin, Julia R

“…Submucosal glands (SMGs) are the major site of expression of the cystic fibrosis (CF) transmembrane conductance regulator gene (CFTR) in the human lung. As…”
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Evaluation of the mouse TgTP6.3 tauGFP transgene as a lineage marker in chimeras by MacKay, Gillian E., Keighren, Margaret A., Wilson, Linda, Pratt, Thomas, Flockhart, Jean H., Mason, John O., Price, David J., West, John D.

“…The mouse TgTP6.3 transgene, encoding a tauGFP fusion protein, is becoming widely used but has yet to be fully characterized and evaluated as suitable lineage…”
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Polyploid cells in the mouse ovary by Keighren, Margaret A., Macfadyen, Leah P., Hill, Alan S., Patek, Charles E., Telfer, Evelyn E., West, John D.

“…Cell ploidy in the ovarian follicle and corpus luteum was investigated by DNA in situ hybridization to a reiterated, chromosome 3 transgene in mice that were…”
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Quantitative and spatial information on the composition of chimaeric fetal mouse eyes from single histological sections by West, John D., Hodson, Benjamin A., Keighren, Margaret A.

“…The spatial distribution of cells in chimaeric tissues, composed of two genotypes, provides insights into the extent of cell mixing during development and…”
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Evaluation of methods for one-dimensional spatial analysis of two-dimensional patterns in mouse chimaeras: Spatial analysis of chimaeric tissues by Hodson, Benjamin A., Unbekandt, Mathieu, Keighren, Margaret A., Springbett, Anthea, West, John D.

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