Search Results - "Keifer, Joyce"

Comparative Genomics of the BDNF Gene, Non-Canonical Modes of Transcriptional Regulation, and Neurological Disease by Keifer, Joyce

“…Alternative splicing of genes in the central nervous system is ubiquitous and utilizes many different mechanisms. Splicing generates unique transcript or…”
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MeCP2 regulates Tet1-catalyzed demethylation, CTCF binding, and learning-dependent alternative splicing of the BDNF gene in Turtle by Zheng, Zhaoqing, Ambigapathy, Ganesh, Keifer, Joyce

“…mutations underlying Rett syndrome cause widespread misregulation of gene expression. Functions for MeCP2 other than transcriptional are not well understood…”
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Identification of a functionally distinct truncated BDNF mRNA splice variant and protein in Trachemys scripta elegans by Ambigapathy, Ganesh, Zheng, Zhaoqing, Li, Wei, Keifer, Joyce

“…Brain-derived neurotrophic factor (BDNF) has a diverse functional role and complex pattern of gene expression. Alternative splicing of mRNA transcripts leads…”
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Regulation of AMPAR trafficking in synaptic plasticity by BDNF and the impact of neurodegenerative disease by Keifer, Joyce

“…Research demonstrates that the neural mechanisms underlying synaptic plasticity and learning and memory involve mobilization of AMPA‐type neurotransmitter…”
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BDNF-induced synaptic delivery of AMPAR subunits is differentially dependent on NMDA receptors and requires ERK by Li, Wei, Keifer, Joyce

“…Previous studies using an in vitro model of eyeblink classical conditioning in turtles suggest that increased numbers of synaptic AMPARs supports the…”
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Emergence of in vitro preparations and their contribution to understanding the neural control of behavior in vertebrates by Keifer, Joyce

“…One of the longstanding goals of the field of neuroscience is to understand the neural control of behavior in both invertebrate and vertebrate species. A…”
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Synaptic Mechanisms of Delay Eyeblink Classical Conditioning: AMPAR Trafficking and Gene Regulation in an In Vitro Model by Keifer, Joyce

“…An in vitro model of delay eyeblink classical conditioning was developed to investigate synaptic plasticity mechanisms underlying acquisition of associative…”
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Expression of the Immediate-Early Gene-Encoded Protein Egr-1 ("zif268") during in Vitro Classical Conditioning by Mokin, Maxim, Keifer, Joyce

“…Expression of the immediate-early genes (IEGs) has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is thought to…”
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Glutamate Receptor Subunits are Altered in Forebrain and Cerebellum in Rats Chronically Exposed to the NMDA Receptor Antagonist Phencyclidine by LINDAHL, Josette S, KEIFER, Joyce

“…Phencyclidine (PCP) is a noncompetitive antagonist of the N-methyl-D-aspartate (NMDA) glutamate receptor subtype. It produces transient psychoses in normal…”
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Primetime for Learning Genes by Keifer, Joyce

“…Learning genes in mature neurons are uniquely suited to respond rapidly to specific environmental stimuli. Expression of individual learning genes, therefore,…”
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Sequential Delivery of Synaptic GluA1- and GluA4-containing AMPA Receptors (AMPARs) by SAP97 Anchored Protein Complexes in Classical Conditioning by Zheng, Zhaoqing, Keifer, Joyce

“…Multiple signaling pathways are involved in AMPAR trafficking to synapses during synaptic plasticity and learning. The mechanisms for how these pathways are…”
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Coincidence detection in a neural correlate of classical conditioning is initiated by bidirectional 3‐phosphoinositide‐dependent kinase‐1 signalling and modulated by adenosine receptors by Keifer, Joyce, Zheng, Zhaoqing

“…Key points Signalling mechanisms for coincidence detection of paired stimuli during classical conditioning are fundamental for understanding the mechanisms of…”
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Learning-Dependent Transcriptional Regulation of BDNF by its Truncated Protein Isoform in Turtle by Zheng, Zhaoqing, Keifer, Joyce

“…The vertebrate brain-derived neurotrophic factor ( BDNF ) gene produces a number of alternatively spliced transcripts only some of which generate the BDNF…”
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Cold block of in vitro eyeblink reflexes: evidence supporting the use of hypothermia as an anesthetic in pond turtles by Keifer, Joyce, Zheng, Zhaoqing

“…Use of hypothermia as a means of anesthesia for amphibians and reptiles is prohibited by agencies that establish veterinary guidelines. This has recently been…”
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Thalamocortical connections in the pond turtle Pseudemys scripta elegans by Zhu, Dantong, Lustig, Kurt H, Bifulco, Katherine, Keifer, Joyce

“…Thalamocortical connections are a neuroanatomical feature shared among vertebrates, although the extent and organization of these connections vary among…”
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Putting the "Biology" Back into "Neurobiology": The Strength of Diversity in Animal Model Systems for Neuroscience Research by Keifer, Joyce, Summers, Cliff H

“…Current trends in neuroscience research have moved toward a reliance on rodent animal models to study most aspects of brain function. Such laboratory-reared…”
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Characterization and Transcriptional Activation of the Immediate Early Gene ARC During a Neural Correlate of Classical Conditioning by Zheng, Zhaoqing, Ambigapathy, Ganesh, Keifer, Joyce

“…Plasticity and learning genes require regulatory mechanisms that have the flexibility to respond to a variety of sensory stimuli to generate adaptive…”
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PKA Has a Critical Role in Synaptic Delivery of GluR1- and GluR4-Containing AMPARs During Initial Stages of Acquisition of In Vitro Classical Conditioning by Zheng, Zhaoqing, Keifer, Joyce

“…Neuroscience Group, Division of Basic Biomedical Sciences, University of South Dakota School of Medicine, Vermillion, South Dakota Submitted 2 December 2008;…”
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Oligomeric Amyloid-β Inhibits the Proteolytic Conversion of Brain-derived Neurotrophic Factor (BDNF), AMPA Receptor Trafficking, and Classical Conditioning by Zheng, Zhaoqing, Sabirzhanov, Boris, Keifer, Joyce

“…Amyloid-β (Aβ) peptide is thought to have a significant role in the progressive memory loss observed in patients with Alzheimer disease and inhibits synaptic…”
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Distributed motor commands in the limb premotor network by Houk, J C, Keifer, J, Barto, A G

“…Neuroanatomical studies have demonstrated extensive interconnections between the motor cortex, red nucleus and cerebellum, forming a premotor network for…”
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