Search Results - "Kehrl, John"

The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity by Kehrl, John H.

“…[Display omitted] Leukocyte chemoattractant receptors are members of the G-protein coupled receptor (GPCR) family. Signaling downstream of these receptors…”
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TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy by Shi, Chong-Shan, Kehrl, John H

“…Autophagy delivers cytoplasmic constituents to autophagolysosomes and is linked to both innate and adaptive immunity. Toll-like receptor 4 (TLR4) signaling…”
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Omega-3 free fatty acids suppress macrophage inflammasome activation by inhibiting NF-κB activation and enhancing autophagy by Williams-Bey, Yolanda, Boularan, Cedric, Vural, Ali, Huang, Ning-Na, Hwang, Il-Young, Shan-Shi, Chong, Kehrl, John H

“…The omega-3 (ω3) fatty acid docosahexaenoic acid (DHA) can suppress inflammation, specifically IL-1β production through poorly understood molecular mechanisms…”
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MyD88 and Trif Target Beclin 1 to Trigger Autophagy in Macrophages by Shi, Chong-Shan, Kehrl, John H.

“…The Toll-like receptors (TLR) play an instructive role in innate and adaptive immunity by recognizing specific molecular patterns from pathogens. Autophagy…”
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SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS/TRAF3/TRAF6 signalosome by Shi, Chong-Shan, Qi, Hai-Yan, Boularan, Cedric, Huang, Ning-Na, Abu-Asab, Mones, Shelhamer, James H, Kehrl, John H

“…Coronaviruses (CoV) have recently emerged as potentially serious pathogens that can cause significant human morbidity and death. The severe acute respiratory…”
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Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction by Shi, Chong-Shan, Shenderov, Kevin, Huang, Ning-Na, Kabat, Juraj, Abu-Asab, Mones, Fitzgerald, Katherine A, Sher, Alan, Kehrl, John H

“…Autophagosomes deliver cytoplasmic constituents to lysosomes for degradation. Kehrl and colleagues show that inflammasome activation triggers autophagosome…”
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Cytochrome c Negatively Regulates NLRP3 Inflammasomes by Shi, Chong-Shan, Kehrl, John H

“…The release of cytochrome c from the inner mitochondrial membrane, where it is anchored by caridolipin, triggers the formation of the Apaf-1 apoptosome…”
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SARS-Coronavirus Open Reading Frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes by Shi, Chong-Shan, Nabar, Neel R., Huang, Ning-Na, Kehrl, John H.

“…The SARS (severe acute respiratory syndrome) outbreak was caused by a coronavirus (CoV) named the SARS-CoV. SARS pathology is propagated both by direct…”
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Inhibition of WNK kinases in NK cells disrupts cellular osmoregulation and control of tumor metastasis by Kim, Ji Sung, Kehrl, John H

“…The serine/threonine With-No-Lysine (WNK) kinase family function in blood pressure control, electrolyte homeostasis, and cellular osmoregulation. These kinases…”
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Roles of autophagy in HIV infection by Dinkins, Christina, Pilli, Manohar, Kehrl, John H

“…Autophagy is a major cellular pathway, which at basal levels regulates and maintains the cytoplasmic environment through the capture, isolation and digestion…”
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Autophagy and inflammasomes by Harris, James, Lang, Tali, Thomas, Jacinta P.W., Sukkar, Maria B., Nabar, Neel R., Kehrl, John H.

“…•Loss of autophagy increases inflammasome activation.•Autophagy removes inflammasome-activating stimuli from the cytosol.•Autophagy degrades inflammasome…”
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Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus by Kamenyeva, Olena, Boularan, Cedric, Kabat, Juraj, Cheung, Gordon Y C, Cicala, Claudia, Yeh, Anthony J, Chan, June L, Periasamy, Saravanan, Otto, Michael, Kehrl, John H

“…Neutrophils form the first line of host defense against bacterial pathogens. They are rapidly mobilized to sites of infection where they help marshal host…”
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SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell death by Yue, Yuan, Nabar, Neel R., Shi, Chong-Shan, Kamenyeva, Olena, Xiao, Xun, Hwang, Il-Young, Wang, Min, Kehrl, John H.

“…The molecular mechanisms underlying the severe lung pathology that occurs during SARS-CoV infections remain incompletely understood. The largest of the…”
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AKT Regulates NLRP3 Inflammasome Activation by Phosphorylating NLRP3 Serine 5 by Zhao, Wei, Shi, Chong-Shan, Harrison, Kathleen, Hwang, Il-Young, Nabar, Neel R, Wang, Min, Kehrl, John H

“…The cytosolic pattern recognition receptor NLRP3 senses host-derived danger signals and certain microbe-derived products in both humans and rodents. NLRP3…”
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Biased S1PR1 Signaling in B Cells Subverts Responses to Homeostatic Chemokines, Severely Disorganizing Lymphoid Organ Architecture by Hwang, Il-Young, Park, Chung, Harrison, Kathleen, Kehrl, John H

“…Ligand-engaged chemoattractant receptors trigger Gα subunit nucleotide exchange, stimulating the activation of downstream effector molecules. Activated…”
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An integrin/MFG-E8 shuttle loads HIV-1 viral-like particles onto follicular dendritic cells in mouse lymph node by Park, Chung, Kehrl, John H

“…During human immunodeficiency virus-1 (HIV-1) infection lymphoid organ follicular dendritic cells (FDCs) serve as a reservoir for infectious virus and an…”
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Inflammasome Inhibition Links IRGM to Innate Immunity by Nabar, Neel R., Kehrl, John H.

“…IRGM is a risk factor for several inflammatory diseases, yet no direct link to immune regulation had been shown. In this issue of Molecular Cell, Mehto et al…”
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Bcl-2 regulates pyroptosis and necroptosis by targeting BH3-like domains in GSDMD and MLKL by Shi, Chong-Shan, Kehrl, John H.

“…Apoptosis is a form of programmed cell death in multicellular organisms. Bcl-2 prevents apoptosis and promotes cellular survival by neutralizing BH3…”
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A CRISPR screen targeting PI3K effectors identifies RASA3 as a negative regulator of LFA-1-mediated adhesion in T cells by Johansen, Kristoffer H, Golec, Dominic P, Huang, Bonnie, Park, Chung, Thomsen, Julie H, Preite, Silvia, Cannons, Jennifer L, Garçon, Fabien, Schrom, Edward C, Courrèges, Christina J F, Veres, Tibor Z, Harrison, James, Nus, Meritxell, Phelan, James D, Bergmeier, Wolfgang, Kehrl, John H, Okkenhaug, Klaus, Schwartzberg, Pamela L

“…The integrin lymphocyte function-associated antigen 1 (LFA-1) helps to coordinate the migration, adhesion, and activation of T cells through interactions with…”
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Implications of non-canonical G-protein signaling for the immune system by Boularan, Cédric, Kehrl, John H.

“…Heterotrimeric guanine nucleotide-binding proteins (G proteins), which consist of three subunits α, β, and γ, function as molecular switches to control…”
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