Search Results - "Kehoe, Patrick G"

Cognitive impact of COVID-19: looking beyond the short term by Miners, Scott, Kehoe, Patrick G, Love, Seth

“…COVID-19 is primarily a respiratory disease but up to two thirds of hospitalised patients show evidence of central nervous system (CNS) damage, predominantly…”
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Repurposing antihypertensive drugs for the prevention of Alzheimer’s disease: a Mendelian randomization study by Walker, Venexia M, Kehoe, Patrick G, Martin, Richard M, Davies, Neil M

“…Abstract Background Evidence concerning the potential repurposing of antihypertensives for Alzheimer’s disease prevention is inconclusive. We used Mendelian…”
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ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease by Evans, Charles E., Miners, James S., Piva, Giulia, Willis, Christine L., Heard, David M., Kidd, Emma J., Good, Mark A., Kehoe, Patrick G.

“…Mid-life hypertension and cerebrovascular dysfunction are associated with increased risk of later life dementia, including Alzheimer’s disease (AD). The…”
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Untargeted metabolomic analysis of human plasma indicates differentially affected polyamine and L-arginine metabolism in mild cognitive impairment subjects converting to Alzheimer's disease by Graham, Stewart F, Chevallier, Olivier P, Elliott, Christopher T, Hölscher, Christian, Johnston, Janet, McGuinness, Bernadette, Kehoe, Patrick G, Passmore, Anthony Peter, Green, Brian D

“…This study combined high resolution mass spectrometry (HRMS), advanced chemometrics and pathway enrichment analysis to analyse the blood metabolome of patients…”
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Small RNA modifications in Alzheimer's disease by Zhang, Xudong, Trebak, Fatima, Souza, Lucas A.C., Shi, Junchao, Zhou, Tong, Kehoe, Patrick G., Chen, Qi, Feng Earley, Yumei

“…Background While significant advances have been made in uncovering the aetiology of Alzheimer's disease and related dementias at the genetic level, molecular…”
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Is inhibition of the renin–angiotensin system a new treatment option for Alzheimer's disease? by Kehoe, Patrick G, Dr, Wilcock, Gordon K, FRCP

“…Summary Findings from longitudinal and cross-sectional studies suggest an association between high blood pressure and dementia, and in turn the use of…”
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Alzheimer's disease–like pathology has transient effects on the brain and blood metabolome by Pan, Xiaobei, Nasaruddin, Muhammad Bin, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Anthony P, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Abstract The pathogenesis of Alzheimer's disease (AD) is complex involving multiple contributing factors. The extent to which AD pathology affects the…”
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Pathophysiology of white matter perfusion in Alzheimer’s disease and vascular dementia by Barker, Rachel, Ashby, Emma L., Wellington, Dannielle, Barrow, Vivienne M., Palmer, Jennifer C., Kehoe, Patrick G., Esiri, Margaret M., Love, Seth

“…The pathophysiology of white matter hypoperfusion is poorly understood. Barker et al. quantify ante-mortem hypoperfusion by measuring myelin proteins…”
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Lipid Profiling of Alzheimer's Disease Brain Highlights Enrichment in Glycerol(phospho)lipid, and Sphingolipid Metabolism by Akyol, Sumeyya, Ugur, Zafer, Yilmaz, Ali, Ustun, Ilyas, Gorti, Santosh Kapil Kumar, Oh, Kyungjoon, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Maddens, Michael E, Green, Brian D, Graham, Stewart F

“…Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To gain a more comprehensive understanding of what causes AD and its…”
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Metabolomic Profiling of Bile Acids in Clinical and Experimental Samples of Alzheimer's Disease by Pan, Xiaobei, Elliott, Christopher T, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Hölscher, Christian, McClean, Paula L, Graham, Stewart F, Green, Brian D

“…Certain endogenous bile acids have been proposed as potential therapies for ameliorating Alzheimer's disease (AD) but their role, if any, in the…”
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CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease by Weir, Heather J M, Murray, Tracey K, Kehoe, Patrick G, Love, Seth, Verdin, Eric M, O'Neill, Michael J, Lane, Jon D, Balthasar, Nina

“…Progressive mitochondrial dysfunction contributes to neuronal degeneration in age-mediated disease. An essential regulator of mitochondrial function is the…”
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BIN1 is decreased in sporadic but not familial Alzheimer's disease or in aging by Glennon, Elizabeth B C, Whitehouse, Isobel J, Miners, J Scott, Kehoe, Patrick G, Love, Seth, Kellett, Katherine A B, Hooper, Nigel M

“…Bridging integrator 1 (BIN1) has been implicated in sporadic Alzheimer's disease (AD) by a number of genome wide association studies (GWAS) in a variety of…”
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Distribution and Expression of Picalm in Alzheimer Disease by Baig, Shabnam, Joseph, Sally A, Tayler, Hannah, Abraham, Richard, Owen, Michael J, Williams, Julie, Kehoe, Patrick G, Love, Seth

“…PICALM, the gene encoding phosphatidylinositol-binding clathrin assembly (picalm) protein, was recently shown to be associated with risk of Alzheimer disease…”
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Large Meta-Analysis Establishes the ACE Insertion-Deletion Polymorphism as a Marker of Alzheimer's Disease by Lehmann, Donald J., Cortina-Borja, Mario, Warden, Donald R., Smith, A. David, Sleegers, Kristel, Prince, Jonathan A., van Duijn, Cornelia M., Kehoe, Patrick G.

“…Apolipoprotein E ε4 (APOE*4) is the only fully established susceptibility allele for Alzheimer's disease. One of the most studied candidates is the insertion…”
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What is the impact of regulatory guidance and expiry of drug patents on dementia drug prescriptions in England? A trend analysis in the Clinical Practice Research Datalink by Walker, Venexia M, Davies, Neil M, Kehoe, Patrick G, Martin, Richard M

“…Drugs for dementia have been available in England since 1997. Since their launch, there have been several changes to national guidelines and initiatives that…”
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LRP1 expression in cerebral cortex, choroid plexus and meningeal blood vessels: Relationship to cerebral amyloid angiopathy and APOE status by Ruzali, Wan Adriyani W., Kehoe, Patrick G., Love, Seth

“…► LRP1 mRNA is elevated in meningeal vessels in association with APOE ɛ4. ► LRP1 mRNA is elevated in choroid plexus and meningeal vessels with AD. ► APOE ɛ2 is…”
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Prion protein is decreased in Alzheimer's brain and inversely correlates with BACE1 activity, amyloid-β levels and Braak stage by Whitehouse, Isobel J, Miners, J Scott, Glennon, Elizabeth B C, Kehoe, Patrick G, Love, Seth, Kellett, Katherine A B, Hooper, Nigel M

“…The cellular prion protein (PrP(C)) has been implicated in the development of Alzheimer's disease (AD). PrP(C) decreases amyloid-β (Aβ) production, which is…”
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Dementia risk reduction: why haven't the pharmacological risk reduction trials worked? An in‐depth exploration of seven established risk factors by Peters, Ruth, Breitner, John, James, Sarah, Jicha, Gregory A., Meyer, Pierre‐Francois, Richards, Marcus, Smith, A. David, Yassine, Hussein N., Abner, Erin, Hainsworth, Atticus H., Kehoe, Patrick G., Beckett, Nigel, Weber, Christopher, Anderson, Craig, Anstey, Kaarin J., Dodge, Hiroko H.

“…Identifying the leading health and lifestyle factors for the risk of incident dementia and Alzheimer's disease has yet to translate to risk reduction. To…”
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Divergence in the activity of the N- and C- catalytic domains of ACE1 - implications for the role of the renin-angiotensin system in Alzheimer's disease by Al Mulhim, Noura S, Kehoe, Patrick G, Miners, J Scott

“…Keywords: Angiotensin-II converting enzyme-1 (ACE1), Alzheimer's disease, Renin-angiotensin system, Anti-hypertensives…”
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Evidence That Parietal Lobe Fatty Acids May Be More Profoundly Affected in Moderate Alzheimer's Disease (AD) Pathology Than in Severe AD Pathology by Nasaruddin, Muhammad L, Pan, Xiaobei, McGuinness, Bernadette, Passmore, Peter, Kehoe, Patrick G, Hölscher, Christian, Graham, Stewart F, Green, Brian D

“…Brain is a lipid-rich tissue, and fatty acids (FAs) play a crucial role in brain function, including neuronal cell growth and development. This study used…”
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