Search Results - "Kehoe, P."

CSF evidence of pericyte damage in Alzheimer's disease is associated with markers of blood-brain barrier dysfunction and disease pathology by Miners, J S, Kehoe, P G, Love, S, Zetterberg, H, Blennow, K

“…We aimed to assess the relationship between levels of a cerebrospinal fluid (CSF) marker of pericyte damage, soluble platelet-derived growth factor receptor β…”
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Dysregulation of the renin‐angiotensin system in vascular dementia by Tayler, H. M., Skrobot, O. A., Baron, D. H., Kehoe, P. G., Miners, J. S.

“…The renin‐angiotensin system (RAS) regulates systemic and cerebral blood flow and is dysregulated in dementia. The major aim of this study was to determine if…”
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Angiotensin-converting enzyme (ACE) levels and activity in Alzheimer's disease, and relationship of perivascular ACE-1 to cerebral amyloid angiopathy by Miners, J. S., Ashby, E., Van Helmond, Z., Chalmers, K. A., Palmer, L. E., Love, S., Kehoe, P. G.

“…Aims: Several observations point to the involvement of angiotensin‐converting enzyme‐1 (ACE‐1) in Alzheimer's disease (AD): ACE‐1 cleaves amyloid‐β peptide…”
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BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease by Harris, M., El Hindy, M., Usmari-Moraes, M., Hudd, F., Shafei, M., Dong, M., Hezwani, M., Clark, P., House, M., Forshaw, T., Kehoe, P., Conway, M.E.

“…Leucine, nutrient signal and substrate for the branched chain aminotransferase (BCAT) activates the mechanistic target of rapamycin (mTORC1) and regulates…”
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The cardiovascular and respiratory health of people with schizophrenia by Filik, R., Sipos, A., Kehoe, P. G., Burns, T., Cooper, S. J., Stevens, H., Laugharne, R., Young, G., Perrington, S., McKendrick, J., Stephenson, D., Harrison, G.

“…Objective:  To examine the cardiovascular and respiratory health of people with severe mental illness (SMI) and compare findings with the Health Surveys for…”
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Establishing an MRI-Based Protocol and Atlas of the Bearded Dragon ( Pogona vitticeps ) Brain by Foss, Kari D, Keller, Krista A, Kehoe, Spencer P, Sutton, Bradley P

“…The bearded dragon ( ) has become a popular companion lizard, and as such, clients have increasingly come to expect the application of advanced diagnostic and…”
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Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia by Palmer, J. C., Kehoe, P. G., Love, S.

“…J. C. Palmer, P. G. Kehoe and S. Love (2010) Neuropathology and Applied Neurobiology36, 487–497
Endothelin‐converting enzyme‐1 in Alzheimer's disease and…”
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Zoonotic Bartonella species in cardiac valves of healthy coyotes, California, USA by Kehoe, Spencer P, Chomel, Bruno B, Stuckey, Matthew J, Kasten, Rickie W, Balakrishnan, Nandhakumar, Sacks, Benjamin N, Breitschwerdt, Edward B

“…We investigated whether Bartonella spp. could cause endocarditis in coyotes or localize to cardiac valves before lesions develop. Bartonella DNA was amplified…”
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Reply: Atherosclerosis and vascular cognitive impairment neuropathological guideline by Skrobot, Olivia A, Attems, Johannes, Esiri, Margaret, Hortobágyi, Tibor, Ironside, James W, Kalaria, Rajesh N, King, Andrew, Lammie, G A, Mann, David, Neal, James, Ben-Shlomo, Yoav, Kehoe, P G, Love, Seth

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Leukocyte and Platelet Characteristics of the Giant Panda ( Ailuropoda melanoleuca ): Morphological, Cytochemical, and Ultrastructural Features by Kehoe, Spencer P, Stacy, Nicole I, Frasca, Jr, Salvatore, Stokol, Tracy, Wang, Chengdong, Leach, Kathryn Strayer, Luo, Li, Rivera, Sam

“…The giant panda ( ) is a vulnerable species and a charismatic member of zoological collections worldwide. Despite its importance as a representative species…”
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MMP-2, -3 and -9 levels and activity are not related to Aβ load in the frontal cortex in Alzheimer's disease by Baig, S., Kehoe, P. G., Love, S.

“…Matrix metalloproteinases (MMPs) ‐2, ‐3 and ‐9 are up‐regulated in several cell types on exposure to amyloid β peptide (Aβ) and have Aβ‐degrading activity in…”
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An outbreak of epidemic keratoconjunctivitis in a regional ophthalmology clinic in New South Wales by VINEY, K. A., KEHOE, P. J., DOYLE, B., SHEPPEARD, V., ROBERTS-WITTEVEEN, A. R., SEMIRLI, H., McPHIE, K. A., DWYER, D. E., McANULTY, J. M.

“…The objective of the study was to identify the extent and cause of an outbreak of epidemic keratoconjunctivitis (EKC). The study design was active case finding…”
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Regional differences in effects of APOE ε4 on cognitive impairment in non-demented subjects by Norberg, J, Graff, C, Almkvist, O, Ewers, M, Frisoni, G B, Frölich, L, Hampel, H, Jones, R W, Kehoe, P G, Lenoir, H, Minthon, L, Nobili, F, Olde Rikkert, M, Rigaud, A-S, Scheltens, P, Soininen, H, Spiru, L, Tsolaki, M, Wahlund, L-O, Vellas, B, Wilcock, G, Elias-Sonnenschein, L S, Verhey, F R J, Visser, P J

“…The APOE ε4 allele is a risk factor for Alzheimer's disease (AD). APOE ε4 is common in non-demented subjects with cognitive impairment. In both healthy people…”
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Haplotypes extending across ACE are associated with Alzheimer's disease by Kehoe, Patrick G., Katzov, Hagit, Feuk, Lars, Bennet, Anna M., Johansson, Boo, Wiman, Björn, Faire, Ulf de, Cairns, Nigel J., Wilcock, Gordon K., Brookes, Anthony J., Blennow, Kaj, Prince, Jonathan A.

“…Numerous genes have been implicated in Alzheimer's disease (AD), but, with the exception of a demonstrated association with the ε4 allele of APOE, findings…”
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Susceptibility Locus for Alzheimer's Disease on Chromosome 10 by Myers, Amanda, Holmans, Peter, Marshall, Helen, Kwon, Jennifer, Meyer, David, Ramic, Dzanan, Shears, Shantia, Booth, Jeremy, DeVrieze, Fabienne Wavrant, Crook, Richard, Hamshere, Marian, Abraham, Richard, Tunstall, Nigel, Rice, Francis, Carty, Stephanie, Lillystone, Sara, Kehoe, Pat, Rudrasingham, Varuni, Jones, Lesley, Lovestone, Simon, Perez-Tur, Jordi, Williams, Julie, Owen, Michael J., Hardy, John, Goate, Alison M.

“…The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been linked to risk for late-onset Alzheimer's disease (LOAD). However, 50…”
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O4-4.5 Associations of angiotensin-II receptor blockers and ACE inhibitors with Alzheimer's disease: a nested case-control study within the UK general practice research database by Davies, N, Kehoe, P, Ben-Shlomo, Y, Martin, R

“…ObjectivesTo investigate whether angiotensin II receptor blockers (ARBs) and ACE inhibitors (ACE-Is) are more strongly associated with Alzheimer's disease (AD)…”
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Caveolin-1 and -2 and their relationship to cerebral amyloid angiopathy in Alzheimer's disease by Van Helmond, Z. K., Miners, J. S., Bednall, E., Chalmers, K. A., Zhang, Y., Wilcock, G. K., Love, S., Kehoe, P. G.

“…Cerebral amyloid angiopathy (CAA) affects over 90% of patients with Alzheimer's disease (AD) and increases the risk of cerebral haemorrhage and infarction…”
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Vascular risk and genetics of sporadic late-onset Alzheimer's disease by Panza, F, D'Introno, A, Colacicco, A M, Basile, A M, Capurso, C, Kehoe, P G, Capurso, A, Solfrizzi, V

“…In recent years, it is becoming apparent that genes may play an important role in the development of late-onset Alzheimer's disease (LOAD), and genetic studies…”
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Shifts in angiotensin I converting enzyme insertion allele frequency across Europe: implications for Alzheimer’s disease risk by Panza, F, Solfrizzi, V, D’Introno, A, Colacicco, A M, Capurso, C, Capurso, A, Kehoe, P G

“…[...]we compared our results with the findings from published studies on other European populations. 1, 2, 4 Between June 1998 and October 2001, we…”
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CSF biomarker utilisation and ethical considerations of biomarker assisted diagnosis and research in dementia: perspectives from within the European Alzheimer’s Disease Consortium (EADC) by Slats, D, Spies, P E, Sjögren, M J C, Visser, P-J, Verbeek, M M, Rikkert, M G M Olde, Kehoe, P G

“…Cerebrospinal fluid (CSF) biomarker analysis for dementia diagnostics (ie, the analysis of amyloid [beta]42, total tau and phosphorylated tau) is increasingly…”
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