Search Results - "Kehm, Victoria M."
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Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity
Published in Cell reports (Cambridge) (20-09-2016)“…The accumulation and propagation of misfolded α-synuclein (α-Syn) is a central feature of Parkinson’s disease and other synucleinopathies. Molecular…”
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Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Published in The Journal of experimental medicine (07-05-2012)“…The accumulation of misfolded proteins is a fundamental pathogenic process in neurodegenerative diseases. However, the factors that trigger aggregation of…”
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α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
Published in The Journal of neuroscience (06-07-2011)“…Abnormally accumulated α-synuclein (α-syn) is a pathological hallmark of Lewy body-related disorders such as Parkinson's disease (PD) and dementia with Lewy…”
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