Search Results - "Kehlenbach, Ralph H."

CRM1-mediated nuclear export: to the pore and beyond by Hutten, Saskia, Kehlenbach, Ralph H

“…CRM1 (chromosome region maintenance 1; also referred to as exportin1 or Xpo1) is a member of the importin β superfamily of nuclear transport receptors,…”
Get full text

The Part and the Whole: functions of nucleoporins in nucleocytoplasmic transport by Wälde, Sarah, Kehlenbach, Ralph H

“…The nuclear pore complex (NPC) functions as a selective gate that allows passage of certain molecules into and out of the nucleus and restricts that of others…”
Get full text

Nuclear egress of TDP-43 and FUS occurs independently of Exportin-1/CRM1 by Ederle, Helena, Funk, Christina, Abou-Ajram, Claudia, Hutten, Saskia, Funk, Eva B. E., Kehlenbach, Ralph H., Bailer, Susanne M., Dormann, Dorothee

“…TDP-43 and FUS are nuclear proteins with multiple functions in mRNA processing. They play key roles in ALS (amyotrophic lateral sclerosis) and FTD…”
Get full text

Targeting of LRRC59 to the Endoplasmic Reticulum and the Inner Nuclear Membrane by Blenski, Marina, Kehlenbach, Ralph H

“…LRRC59 (leucine-rich repeat-containing protein 59) is a tail-anchored protein with a single transmembrane domain close to its C-terminal end that localizes to…”
Get full text

Proteomic mapping by rapamycin-dependent targeting of APEX2 identifies binding partners of VAPB at the inner nuclear membrane by James, Christina, Müller, Marret, Goldberg, Martin W., Lenz, Christof, Urlaub, Henning, Kehlenbach, Ralph H.

“…Vesicle-associated membrane protein–associated protein B (VAPB) is a tail-anchored protein that is present at several contact sites of the endoplasmic…”
Get full text

The Interactome of the VAP Family of Proteins: An Overview by James, Christina, Kehlenbach, Ralph H.

“…Membrane contact sites (MCS) are sites of close apposition of two organelles that help in lipid transport and synthesis, calcium homeostasis and several other…”
Get full text

Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export by Port, Sarah A., Monecke, Thomas, Dickmanns, Achim, Spillner, Christiane, Hofele, Romina, Urlaub, Henning, Ficner, Ralf, Kehlenbach, Ralph H.

“…CRM1 is the major nuclear export receptor. During translocation through the nuclear pore, transport complexes transiently interact with phenylalanine-glycine…”
Get full text

Resolution doubling in fluorescence microscopy with confocal spinning-disk image scanning microscopy by Schulz, Olaf, Pieper, Christoph, Clever, Michaela, Pfaff, Janine, Ruhlandt, Aike, Kehlenbach, Ralph H., Wouters, Fred S., Großhans, Jörg, Bunt, Gertrude, Enderlein, Jörg

“…We demonstrate how a conventional confocal spinning-disk (CSD) microscope can be converted into a doubly resolving image scanning microscopy (ISM) system…”
Get full text

Sequestosome 1 Is Part of the Interaction Network of VAPB by James, Christina, Lenz, Christof, Urlaub, Henning, Kehlenbach, Ralph H

“…VAPB (Vesicle-Associated-membrane Protein-associated protein B) is a tail-anchored membrane protein of the endoplasmic reticulum that can also be detected at…”
Get full text

Nup214 Is Required for CRM1-Dependent Nuclear Protein Export In Vivo by Hutten, Saskia, Kehlenbach, Ralph H.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Extensive Identification and In-depth Validation of Importin 13 Cargoes by Baade, Imke, Spillner, Christiane, Schmitt, Kerstin, Valerius, Oliver, Kehlenbach, Ralph H.

“…Importin 13 is a member of the importin β family of transport receptors. Unlike most family members, importin 13 mediates both, nuclear protein import and…”
Get full text

Defective nuclear import of Tpr in Progeria reflects the Ran sensitivity of large cargo transport by Snow, Chelsi J, Dar, Ashraf, Dutta, Anindya, Kehlenbach, Ralph H, Paschal, Bryce M

“…The RanGTPase acts as a master regulator of nucleocytoplasmic transport by controlling assembly and disassembly of nuclear transport complexes. RanGTP is…”
Get full text

Several Phenylalanine-Glycine Motives in the Nucleoporin Nup214 Are Essential for Binding of the Nuclear Export Receptor CRM1 by Roloff, Stephanie, Spillner, Christiane, Kehlenbach, Ralph H.

“…Nucleoporins containing phenylalanine glycine (FG) repeats play an important role in nucleocytoplasmic transport as they bind to transport receptors and…”
Get full text

The Oncogenic Fusion Proteins SET-Nup214 and Sequestosome-1 (SQSTM1)-Nup214 Form Dynamic Nuclear Bodies and Differentially Affect Nuclear Protein and Poly(A)+ RNA Export by Port, Sarah A., Mendes, Adélia, Valkova, Christina, Spillner, Christiane, Fahrenkrog, Birthe, Kaether, Christoph, Kehlenbach, Ralph H.

“…Genetic rearrangements are a hallmark of several forms of leukemia and can lead to oncogenic fusion proteins. One example of an affected chromosomal region is…”
Get full text

The SQSTM1-NUP214 fusion protein interacts with Crm1, activates Hoxa and Meis1 genes, and drives leukemogenesis in mice by Lavau, Catherine P, Aumann, Waitman K, Sze, Sei-Gyung K, Gupta, Veerain, Ripple, Katelyn, Port, Sarah A, Kehlenbach, Ralph H, Wechsler, Daniel S

“…The NUP98 and NUP214 nucleoporins (NUPs) are recurrently fused to heterologous proteins in leukemia. The resulting chimeric oncoproteins retain the…”
Get full text

Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence by Bonnin, Edith, Cabochette, Pauline, Filosa, Alessandro, Jühlen, Ramona, Komatsuzaki, Shoko, Hezwani, Mohammed, Dickmanns, Achim, Martinelli, Valérie, Vermeersch, Marjorie, Supply, Lynn, Martins, Nuno, Pirenne, Laurence, Ravenscroft, Gianina, Lombard, Marcus, Port, Sarah, Spillner, Christiane, Janssens, Sandra, Roets, Ellen, Van Dorpe, Jo, Lammens, Martin, Kehlenbach, Ralph H, Ficner, Ralf, Laing, Nigel G, Hoffmann, Katrin, Vanhollebeke, Benoit, Fahrenkrog, Birthe

“…Nucleoporins build the nuclear pore complex (NPC), which, as sole gate for nuclear-cytoplasmic exchange, is of outmost importance for normal cell function…”
Get full text

The Nucleoporin Nup358/RanBP2 Promotes Nuclear Import in a Cargo‐ and Transport Receptor‐Specific Manner by Wälde, Sarah, Thakar, Ketan, Hutten, Saskia, Spillner, Christiane, Nath, Annegret, Rothbauer, Ulrich, Wiemann, Stefan, Kehlenbach, Ralph H.

“…In vertebrates, the nuclear pore complex (NPC), the gate for transport of macromolecules between the nucleus and the cytoplasm, consists of approximately 30…”
Get full text

MD Simulations and FRET Reveal an Environment-Sensitive Conformational Plasticity of Importin-β by Halder, Kangkan, Dölker, Nicole, Van, Qui, Gregor, Ingo, Dickmanns, Achim, Baade, Imke, Kehlenbach, Ralph H., Ficner, Ralf, Enderlein, Jörg, Grubmüller, Helmut, Neumann, Heinz

“…The nuclear pore complex mediates nucleocytoplasmic transport of macromolecules in eukaryotic cells. Transport through the pore is restricted by a hydrophobic…”
Get full text

nuclear pore component Nup358 promotes transportin-dependent nuclear import by Hutten, Saskia, Wälde, Sarah, Spillner, Christiane, Hauber, Joachim, Kehlenbach, Ralph H

“…Nup358 (also known as RanBP2), a component of the cytoplasmic filaments of the nuclear pore complex, has been implicated in various nucleocytoplasmic transport…”
Get full text

Notch1 signaling is mediated by importins alpha 3, 4, and 7 by Huenniger, Kerstin, Krämer, Andreas, Soom, Malle, Chang, Iree, Köhler, Matthias, Depping, Reinhard, Kehlenbach, Ralph H, Kaether, Christoph

“…The Notch signaling pathway is an important regulation system for the development and self-renewal of different tissues. A specific feature of this signaling…”
Get full text