Search Results - "Kehl, Niklas"

Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) is localized in lysosomes and mediates resistance against kinase inhibitors by Haberkorn, Bastian, Oswald, Stefan, Kehl, Niklas, Gessner, Arne, Taudte, R Verena, Dobert, Jan Philipp, Zunke, Friederike, Fromm, Martin F, König, Jörg

“…Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3), a splice variant of the hepatic uptake transporter OATP1B3 (liver-type; Lt-OATP1B3), is…”
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Intrathecal activation of CD8+ memory T cells in IgG4‐related disease of the brain parenchyma by Friedrich, Mirco, Kehl, Niklas, Engelke, Niko, Kraus, Josephine, Lindner, Katharina, Münch, Philipp, Mildenberger, Iris, Groden, Christoph, Gass, Achim, Etminan, Nima, Fatar, Marc, von Deimling, Andreas, Reuss, David, Platten, Michael, Bunse, Lukas

“…IgG4‐related disease (IgG4‐RD) is a fibroinflammatory disorder signified by aberrant infiltration of IgG4‐restricted plasma cells into a variety of organs…”
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IgE type multiple myeloma exhibits hypermutated phenotype and tumor reactive T cells by Kehl, Niklas, Kilian, Michael, Michel, Julius, Wagner, Tim R, Uhrig, Sebastian, Brobeil, Alexander, Sester, Lilli-Sophie, Blobner, Sven, Steiger, Simon, Hundemer, Michael, Weinhold, Niels, Rippe, Karsten, Fröhling, Stefan, Eichmüller, Stefan B, Bunse, Lukas, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Platten, Michael, Raab, Marc-Steffen, Friedrich, Mirco J

“…Multiple myeloma (MM) is a hematological malignancy originating from malignant and clonally expanding plasma cells. MM can be molecularly stratified, and its…”
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857 Dose- and time-dependent immune cell dynamics in irradiated gliomas by Agardy, Dennis A, Michel, Julius, Boztepe, Berin, Hunger, Jessica, Kehl, Niklas, Kourtesakis, Alexandros, Geller, Julia, Chih, Yu-Chan, Jähne, Kristine, Sachs, Viktoria, Fischer, Manuel, Breckwoldt, Michael, Wick, Wolfgang, Bunse, Theresa, Bunse, Lukas, Platten, Michael

“…BackgroundResection followed by radio-chemotherapy remains the mainstay of standard-of-care for patients with malignant brain tumors. Immunotherapies such as…”
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Rhodium‐Catalyzed Anti‐Markovnikov Transfer Hydroiodination of Terminal Alkynes by Boehm, Philip, Kehl, Niklas, Morandi, Bill

“…A rhodium‐catalyzed anti‐Markovnikov hydroiodination of aromatic and aliphatic terminal alkynes is reported. Depending on the choice of ligand and substrate,…”
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Dysfunctional dendritic cells limit antigen-specific T cell response in glioma by Friedrich, Mirco, Hahn, Markus, Michel, Julius, Sankowski, Roman, Kilian, Michael, Kehl, Niklas, Günter, Manina, Bunse, Theresa, Pusch, Stefan, von Deimling, Andreas, Wick, Wolfgang, Autenrieth, Stella E, Prinz, Marco, Platten, Michael, Bunse, Lukas

“…Dendritic cells (DC), the most potent professional antigen presenting cells capable of effective cross-presentation, have been demonstrated to license T helper…”
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Rhodium‐katalysierte Anti‐Markovnikov Hydroiodierung von Terminalen Alkinen by Boehm, Philip, Kehl, Niklas, Morandi, Bill

“…Wir beschreiben eine Rhodium‐katalysierte anti‐Markovnikov Hydroiodierung von terminalen aromatischen und aliphatischen Alkinen. Je nach Wahl des Liganden und…”
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The pre-existing T cell landscape determines the response to bispecific T cell engagers in multiple myeloma patients by Friedrich, Mirco J., Neri, Paola, Kehl, Niklas, Michel, Julius, Steiger, Simon, Kilian, Michael, Leblay, Noémie, Maity, Ranjan, Sankowski, Roman, Lee, Holly, Barakat, Elie, Ahn, Sungwoo, Weinhold, Niels, Rippe, Karsten, Bunse, Lukas, Platten, Michael, Goldschmidt, Hartmut, Müller-Tidow, Carsten, Raab, Marc-Steffen, Bahlis, Nizar J.

“…Bispecific T cell engagers (TCEs) have shown promise in the treatment of various cancers, but the immunological mechanism and molecular determinants of primary…”
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P-022 Discovery of Shared, MHC-Promiscuous Antigens in Multiple Myeloma Patients by Kehl, Niklas, Hernandez, Gabrielle, Ctortecka, Claudia, Weinhold, Niels, Abelin, Jennifer, Carr, Steven, Raab, Marc, Friedrich, Mirco

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A supervised machine-learning approach for the efficient development of a multi method (LC-MS) for a large number of drugs and subsets thereof: focus on oral antitumor agents by Kehl, Niklas, Gessner, Arne, Maas, Renke, Fromm, Martin F, Taudte, R Verena

“…Accumulating evidence argues for a more widespread use of therapeutic drug monitoring (TDM) to support individualized medicine, especially for therapies where…”
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Mapping the Multiple Myeloma T Cell Landscape By Immunotherapeutic Perturbation Reveals Mechanism and Determinants of Response to Bispecific T Cell Engagers by Friedrich, Mirco, Neri, Paola, Leblay, Noemie, Kehl, Niklas, Michel, Julius, Lee, Holly, Barakat, Elie, Ahn, Sungwoo, Goldschmidt, Hartmut, Platten, Michael, Weinhold, Niels, Raab, Marc-Steffen, Bahlis, Nizar J.

“…Immunotherapies have transformed the clinical care of patients with cancer. Bispecific T cell engagers (TCEs) have recently entered early-phase clinical trials…”
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Tumor Reactive T Cells Reside in the Bone Marrow and Are Associated with Clinical Response to Hematological Malignancies by Wagner, Tim Robin, Kehl, Niklas, Steiger, Simon, Kilian, Michael, Foster, Kane, Boschert, Tamara, Hernandez, Gabrielle M., Abelin, Jennifer, Lindner, Katharina, Sester, Lilli Sophie, Frenking, Jan, Schönfelder, Bruno, Galas-Filipowicz, Daria, Fitzsimons, Evie, Green, Edward W., Schmidt, Patrick, Uhrig, Sebastian, Bunse, Lukas, Chain, Benny, Goldschmidt, Hartmut, Weinhold, Niels, Fröhling, Stefan, Müller-Tidow, Carsten, Carr, Steven A., Yong, Kwee, Rippe, Karsten, Raab, Marc S., Platten, Michael, Eichmüller, Stefan B, Friedrich, Mirco Julian

“…T cell receptors (TCRs) play a crucial role in orchestrating cellular immunity in both health and disease, particularly in the context of cancer. Although…”
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Entwicklung, Optimierung, Validierung und Anwendung Einer LC-MS Methode für die Simultane Quantifizierung Einer Vielzahl von Oralen Antitumortherapeutika In Humanplasma als Basis für Eine Zukünftige, Routinemäßige Expositionsabschätzung von Tumorpatienten by Kehl, Niklas

“…Tumorerkrankungen sind für etwa 25 % aller Todesfälle in Deutschland verantwortlich und nach Herz-Kreislauf-Erkrankungen die zweithäufigste Todesursache. Die…”
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Discovery of Tumor Reactive T Cell Receptors in Newly Diagnosed Multiple Myeloma by Friedrich, Mirco, Kehl, Niklas, Steiger, Simon, Wagner, Tim Robin, Lindner, Katharina, Kilian, Michael, Michel, Julius, Uhrig, Sebastian, Lutz, Raphael, Prokoph, Nina, Poos, Alexandra M, John, Lukas, Sester, Lilli Sophie, Weinhold, Niels, Fröhling, Stefan, Green, Edward W, Bunse, Lukas, Neri, Paola, Bahlis, Nizar Jacques, Rippe, Karsten, Eichmüller, Stefan, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Platten, Michael, Raab, Marc S

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P-220 Discovery of tumor-reactive T cell receptors by functional single cell interaction analyses in patients with newly diagnosed multiple myeloma by Wagner, Tim, Kehl, Niklas, Steiger, Simon, Kilian, Michael, Boschert, Tamara, Lindner, Katharina, Schönfelder, Bruno, Rippe, Karsten, Tidow, Carsten-Muller, Goldschmidt, Hartmut, Raab, Marc, Platten, Michael, Eichmüller, Stefan, Friedrich, Mirco

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An Easily Expandable Multi-Drug LC-MS Assay for the Simultaneous Quantification of 57 Oral Antitumor Drugs in Human Plasma by Kehl, Niklas, Schlichtig, Katja, Dürr, Pauline, Bellut, Laura, Dörje, Frank, Fietkau, Rainer, Pavel, Marianne, Mackensen, Andreas, Wullich, Bernd, Maas, Renke, Fromm, Martin F, Gessner, Arne, Taudte, R Verena

“…Oral anticancer drugs have led to significant improvements in the treatment of multiple tumor entities. However, in patients undergoing oral antitumor therapy,…”
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Abstract 14: Identification of tumor-reactive T cell receptors through functional single cell interaction analyses for personalized T cell therapy by Wagner, Tim Robin, Kehl, Niklas, Steiger, Simon, Kilian, Michael, Schönfelder, Bruno, Boschert, Tamara, Lindner, Katharina, Schmidt, Patrick, Rippe, Karsten, Goldschmidt, Hartmut, Raab, Marc-Steffen, Platten, Michael, Friedrich, Mirco, Eichmüller, Stefan B.

“…Abstract Innovative immunotherapy approaches such as adoptive transfer of chimeric antigen receptor (CAR) T cells or tumor infiltrating lymphocytes (TILs) have…”
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OAB-027: Discovery of tumor-reactive T cell receptors in multiple myeloma by Kehl, Niklas, Steiger, Simon, Wagner, Tim, Lindner, Katharina, Uhrig, Sebastian, Prokoph, Nina, Poos, Alexandra, John, Lukas, Sester, Lilli Sophie, Rippe, Karsten, Weinhold, Niels, Froehling, Stefan, Green, Edward, Bunse, Lukas, Eichmueller, Stefan, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Platten, Michael, Raab, Marc S., Friedrich, Mirco

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OAB-002: The preexisting T cell landscape determines response to T cell-engagers therapy in multiple myeloma by Friedrich, Mirco, Kehl, Niklas, Neri, Paola, Michel, Julius, Leblay, Noemi, Maity, Ranjan, Kilian, Michael, Lee, Holly, Barakat, Elie, Ahn, Sungwoo, Steiger, Simon, Sankowski, Roman, Weinhold, Niels, Rippe, Karsten, Bunse, Lukas, Platten, Michael, Mülle-Tidow, Carsten, Goldschmidt, Hartmut, Raab, Marc S., Bahlis, Nizar

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The immunoglobulin superfamily ligand B7H6 subjects T cell responses to NK cell surveillance by Kilian, Michael, Friedrich, Mirco J, Lu, Kevin Hai-Ning, Vonhören, David, Jansky, Selina, Michel, Julius, Keib, Anna, Stange, Saskia, Hackert, Nicolaj, Kehl, Niklas, Hahn, Markus, Habel, Antje, Jung, Stefanie, Jähne, Kristine, Sahm, Felix, Betge, Johannes, Cerwenka, Adelheid, Westermann, Frank, Dreger, Peter, Raab, Marc S, Meindl-Beinker, Nadja M, Ebert, Matthias, Bunse, Lukas, Müller-Tidow, Carsten, Schmitt, Michael, Platten, Michael

“…Understanding the mechanisms that regulate T cell immunity is critical for the development of effective therapies for diseases associated with T cell…”
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