Search Results - "Kehl, Margaret"

Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response by Surls, Jacqueline, Nazarov-Stoica, Cristina, Kehl, Margaret, Olsen, Cara, Casares, Sofia, Brumeanu, Teodor-D

“…Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-rich microdomains of the plasma membrane known as lipid rafts…”
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Double Negative (CD3+4−8−) TCRαβ Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes by Duncan, Beverly, Nazarov–Stoica, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Brumeanu, Teodor-D.

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Double negative (CD3+ 4- 8-) TCR alphabeta splenic cells from young NOD mice provide long-lasting protection against type 1 diabetes by Duncan, Beverly, Nazarov-Stoica, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Brumeanu, Teodor-D

“…Double negative CD3(+)4(-)8(-) TCR alphabeta splenic cells (DNCD3) can suppress the immune responses to allo and xenografts, infectious agents, tumors, and…”
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Multicomponent Pseudomonas aeruginosa Vaccines Eliciting Th17 Cells and Functional Antibody Responses Confer Enhanced Protection against Experimental Acute Pneumonia in Mice by Shaikh, Mohammad Omar Faruk, Schaefers, Matthew M., Merakou, Christina, DiBlasi, Marco, Bonney, Sarah, Liao, Tiffany, Zurakowski, David, Kehl, Margaret, Tabor, David E., DiGiandomenico, Antonio, Priebe, Gregory P.

“…The Gram-negative pathogen Pseudomonas aeruginosa is a common cause of pneumonia in hospitalized patients. Its increasing antibiotic resistance and widespread…”
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A Bispecific Monoclonal Antibody Targeting Psl and PcrV Enhances Neutrophil-Mediated Killing of Pseudomonas aeruginosa in Patients with Bronchiectasis by Long, Merete B, Gilmour, Amy, Kehl, Margaret, Tabor, David E, Keller, Ashley E, Warrener, Paul, Gopalakrishnan, Vancheswaran, Rosengren, Sanna, Crichton, Megan L, McIntosh, Eve, Giam, Yan Hui, Keir, Holly R, Brailsford, Wayne, Hughes, Rod, Belvisi, Maria G, Sellman, Bret R, DiGiandomenico, Antonio, Chalmers, James D

“…infection is associated with worse outcomes in bronchiectasis. Impaired neutrophil antimicrobial responses contribute to bacterial persistence. Gremubamab is a…”
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Increased innate immune activation induces protective RSV-specific lung-resident memory T cells in neonatal mice by Malloy, Allison M.W., Lu, Zhongyan, Kehl, Margaret, Pena DaMata, Jarina, Lau-Kilby, Annie W., Turfkruyer, Mathilde

“…Young infants frequently experience respiratory tract infections, yet vaccines designed to provide mucosal protection are lacking. Localizing pathogen-specific…”
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Distinct innate signaling and activation of dendritic cells during the neonatal period determines their functional response to respiratory syncytial virus infection by Lau-Kilby, Annie W, Kehl, Margaret, Malloy, Allison MW

“…Dendritic cells (DCs) are among the first to respond to infection, providing the critical link between innate and adaptive immunity. Neonates often have weak…”
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Type I IFN ineffectively activates neonatal dendritic cells limiting respiratory antiviral T-cell responses by Lau-Kilby, Annie W., Turfkruyer, Mathilde, Kehl, Margaret, Yang, Lijuan, Buchholz, Ursula J., Hickey, Kimberly, Malloy, Allison M. W.

“…Insufficient T-cell responses contribute to the increased burden of viral respiratory disease in infancy. Neonatal dendritic cells (DCs) often provide…”
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Differential antigen presentation and transport by neonatal and adult dendritic cell subsets during Respiratory Syncytial Virus (RSV) infection by Lau-Kilby, Annie W, Kehl, Margaret, Malloy, Allison MW

“…Dendritic cells (DCs) are critical for the induction of anti-viral CD8+ T cells. Young infants mount poor antiviral responses contributing to increased disease…”
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Local Respiratory Viral Surveillance Can Focus Public Health Interventions to Decrease Influenza Disease Burden by Crouch, Elena, Gonzalez, Jonathan, Jacobs, Erin, Schaecher, Kurt, Kehl, Margaret, Ottolini, Martin, Malloy, Allison

“…ABSTRACT Background Respiratory viruses are an important cause of nonbattle injury disease and contribute to the top seven reasons for medical encounters. In…”
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Differential effect of CD4+ Foxp3+ T-regulatory cells on the B and T helper cell responses to influenza virus vaccination by Surls, Jacqueline, Nazarov-Stoica, Cristina, Kehl, Margaret, Casares, Sofia, Brumeanu, Teodor-D

“…Abstract The T-regulatory (T-reg) cells restrict the T-cell functions in various viral infections including influenza infection. However little is known about…”
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Double Negative (CD3+4−8−) TCRαβ Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes by Duncan, Beverly, Cristina Nazarov–Stoica, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Teodor-D Brumeanu

“…Background Double negative CD3+4−8− TCRαβ splenic cells (DNCD3) can suppress the immune responses to allo and xenografts, infectious agents, tumors, and some…”
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Perinatal exposure to low levels of carbon monoxide impairs neurobehavior in adult mice by O'Neill, John Timothy, Kehl, Margaret L, Johnson, Kristopher P, Cravedi, Kevin, Barry, Erin S, Grunberg, Neil E

“…Abstract only…”
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Reversal of type 1 diabetes by a new MHC II‐peptide chimera: “Single‐epitope‐mediated suppression” to stabilize a polyclonal autoimmune T‐cell process by Lin, Marvin, Stoica‐Nazarov, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Olsen, Cara, Brumeanu, Teodor D., Casares, Sofia

“…Polyclonality of self‐reactive CD4+ T cells is the hallmark of several autoimmune diseases like type 1 diabetes. We have previously reported that a soluble…”
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Genotoxicity of 10 cigarette smoke condensates in four test systems: Comparisons between assays and condensates by DeMarini, David M., Gudi, Ramadevi, Szkudlinska, Anna, Rao, Meena, Recio, Leslie, Kehl, Margaret, Kirby, Paul E., Polzin, Gregory, Richter, Patricia A.

“…The particulate fraction of cigarette smoke, cigarette smoke condensate (CSC), is genotoxic in many short-term in vitro tests and is carcinogenic in rodents…”
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Double Negative TCR[alpha][beta] Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes by Duncan, Beverly, Nazarov-Stoica, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Brumeanu, Teodor-D

“…Background Double negative CD3.sup.+ 4.sup.- 8.sup.- TCR[alpha][beta] splenic cells (DNCD3) can suppress the immune responses to allo and xenografts,…”
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Double Negative by Duncan, Beverly, Nazarov-Stoica, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Brumeanu, Teodor-D

“…Background Double negative CD3.sup.+ 4.sup.- 8.sup.- TCR[alpha][beta] splenic cells (DNCD3) can suppress the immune responses to allo and xenografts,…”
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Corrigendum to “Genotoxicity of 10 cigarette smoke condensates in four test systems: Comparisons between assays and condensates”. [Mutat. Res. 650 (2008) 15–29] by DeMarini, David M., Gudi, Ramadevi, Szkudlinska, Anna, Rao, Meena, Recio, Leslie, Kehl, Margaret, Kirby, Paul E., Polzin, Gregory, Richter, Patricia A.

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Double Negative (CD3+4-8-) TCRab Splenic Cells from Young NOD Mice Provide Long-Lasting Protection against Type 1 Diabetes by Duncan, Beverly, Nazarov-Stoica, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Brumeanu, Teodor-D

“…Double negative CD3+4-8- TCRab splenic cells (DNCD3) can suppress the immune responses to allo and xenografts, infectious agents, tumors, and some autoimmune…”
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Thymic Development of CD4 super(+25) super(h)i Foxp3 super(+ T-Regulatory Cells Echoes their Suppressogenic Capacity in Periphery) by Nazarov-Stoica, Cristina, Surls, Jacqueline, Kehl, Margaret, Bona, Constantin, Casares, Sofia, Brumeanu, Teodor-D

“…The CD4 super(+25) super(h)iFoxp3 super(+ T regulatory (T-reg) cells are naturally-born in thymus and they are critical for maintaining the tolerance to self…”
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