Search Results - "Kefi, Rym"

Genetic diversity of variants involved in drug response among Tunisian and Italian populations toward personalized medicine by Jmel, Haifa, Sarno, Stefania, Giuliani, Cristina, Boukhalfa, Wided, Abdelhak, Sonia, Luiselli, Donata, Kefi, Rym

“…Adverse drug reactions (ADR) represent a significant contributor to morbidity and mortality, imposing a substantial financial burden. Genetic ancestry plays a…”
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Pharmacogenetic landscape of pain management variants among Mediterranean populations by Jmel, Haifa, Boukhalfa, Wided, Gouiza, Ismail, Seghaier, Roua Ouled, Dallali, Hamza, Kefi, Rym

“…Chronic pain is a major socioeconomic burden in the Mediterranean region. However, we noticed an under-representation of these populations in the…”
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Decoding the genetic relationship between Alzheimer's disease and type 2 diabetes: potential risk variants and future direction for North Africa by Boukhalfa, Wided, Jmel, Haifa, Kheriji, Nadia, Gouiza, Ismail, Dallali, Hamza, Hechmi, Mariem, Kefi, Rym

“…Alzheimer's disease (AD) and Type 2 diabetes (T2D) are both age-associated diseases. Identification of shared genes could help develop early diagnosis and…”
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Founder mutations in Tunisia: implications for diagnosis in North Africa and Middle East by Romdhane, Lilia, Kefi, Rym, Azaiez, Hela, Ben Halim, Nizar, Dellagi, Koussay, Abdelhak, Sonia

“…Tunisia is a North African country of 10 million inhabitants. The native background population is Berber. However, throughout its history, Tunisia has been the…”
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The Role of Dietary Intake in Type 2 Diabetes Mellitus: Importance of Macro and Micronutrients in Glucose Homeostasis by Kheriji, Nadia, Boukhalfa, Wided, Mahjoub, Faten, Hechmi, Meriem, Dakhlaoui, Thouraya, Mrad, Mehdi, Hadj Salah Bahlous, Afef, Ben Amor, Nadia, Jamoussi, Henda, Kefi, Rym

“…The prevalence of Type 2 diabetes (T2D) is increasing worldwide. Genetics and lifestyle, especially diet, are contributing factors. Analyses of macro- and…”
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Prevalence and risk factors of diabetes mellitus and hypertension in North East Tunisia calling for efficient and effective actions by Kheriji, Nadia, Dakhlaoui, Thouraya, Kamoun Rebai, Wafa, Maatoug, Sonia, Thabet, Mohamed Taher, Mellah, Thouraya, Mrad, Mehdi, Trabelsi, Hajer, Soltani, Manel, Kabbage, Maria, Hassine, Hichem Ben, Hadj Salah Bahlous, Afef, Mahjoub, Faten, Jamoussi, Henda, Abid, Abdelmajid, Abdelhak, Sonia, Kefi, Rym

“…Diabetes and hypertension are a serious public health problem worldwide. In the last decades, prevalence of these two metabolic diseases has dramatically…”
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Expanding the genetic spectrum of mitochondrial diseases in Tunisia: novel variants revealed by whole-exome sequencing by Gouiza, Ismail, Hechmi, Meriem, Zioudi, Abir, Dallali, Hamza, Kheriji, Nadia, Charif, Majida, Le Mao, Morgane, Galai, Said, Kraoua, Lilia, Ben Youssef-Turki, Ilhem, Kraoua, Ichraf, Lenaers, Guy, Kefi, Rym

“…Inherited mitochondrial diseases are the most common group of metabolic disorders caused by a defect in oxidative phosphorylation. They are characterized by a…”
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Pharmacogenetic landscape of Metabolic Syndrome components drug response in Tunisia and comparison with worldwide populations by Jmel, Haifa, Romdhane, Lilia, Ben Halima, Yosra, Hechmi, Meriem, Naouali, Chokri, Dallali, Hamza, Hamdi, Yosr, Shan, Jingxuan, Abid, Abdelmajid, Jamoussi, Henda, Trabelsi, Sameh, Chouchane, Lotfi, Luiselli, Donata, Abdelhak, Sonia, Kefi, Rym

“…Genetic variation is an important determinant affecting either drug response or susceptibility to adverse drug reactions. Several studies have highlighted the…”
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Alpha-mannosidosis in Tunisian consanguineous families: Potential involvement of variants in GHR and SLC19A3 genes in the variable expressivity of cognitive impairment by Mkaouar, Rahma, Riahi, Zied, Charfeddine, Cherine, Chelly, Imen, Boudabbous, Hela, Dallali, Hamza, Bonnet, Crystel, Hechmi, Meriem, Bekri, Soumeya, Zitouna, Nadia, Zekri, Lotfi, Tounsi, Amel, Kefi, Rym, Marrakchi, Jihene, Messaoud, Olfa, Kraoua, Ichraf, Maalej, Sonia, Turki Ben Youssef, Ilhem, Ben Hmid, Ahlem, Giraudet, Fabrice, Bouchoucha, Sami, Tebib, Neji, Besbes, Ghazi, Petit, Christine, Mrad, Ridha, Abdelhak, Sonia, Trabelsi, Mediha

“…Alpha-Mannosidosis (AM) is an ultra-rare storage disorder caused by a deficiency of lysosomal alpha-mannosidase encoded by the MAN2B1 gene. Clinical…”
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Multiallelic Rare Variants in BBS Genes Support an Oligogenic Ciliopathy in a Non-obese Juvenile-Onset Syndromic Diabetic Patient: A Case Report by Dallali, Hamza, Kheriji, Nadia, Kammoun, Wafa, Mrad, Mehdi, Soltani, Manel, Trabelsi, Hajer, Hamdi, Walid, Bahlous, Afef, Ben Ahmed, Melika, Mahjoub, Faten, Jamoussi, Henda, Abdelhak, Sonia, Kefi, Rym

“…Juvenile-onset diabetes may occur in the context of a rare syndromic presentation, suggesting a monogenic etiology rather than a common multifactorial…”
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The first exome wide association study in Tunisia: identification of candidate loci and pathways with biological relevance for type 2 diabetes by Dallali, Hamza, Boukhalfa, Wided, Kheriji, Nadia, Fassatoui, Meriem, Jmel, Haifa, Hechmi, Meriem, Gouiza, Ismail, Gharbi, Mariem, Kammoun, Wafa, Mrad, Mehdi, Taoueb, Marouen, Krir, Asma, Trabelsi, Hajer, Bahlous, Afef, Jamoussi, Henda, Messaoud, Olfa, Abid, Abdelmajid, Kefi, Rym

“…Type 2 diabetes (T2D) is a multifactorial disease involving genetic and environmental components. Several genome-wide association studies (GWAS) have been…”
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Molecular Epidemiology of SARS-CoV-2 in Tunisia (North Africa) through Several Successive Waves of COVID-19 by Chouikha, Anissa, Fares, Wasfi, Laamari, Asma, Haddad-Boubaker, Sondes, Belaiba, Zeineb, Ghedira, Kais, Kammoun Rebai, Wafa, Ayouni, Kaouther, Khedhiri, Marwa, Ben Halima, Samar, Krichen, Henda, Touzi, Henda, Ben Dhifallah, Imen, Guerfali, Fatma Z, Atri, Chiraz, Azouz, Saifeddine, Khamessi, Oussema, Ardhaoui, Monia, Safer, Mouna, Ben Alaya, Nissaf, Guizani, Ikram, Kefi, Rym, Gdoura, Mariem, Triki, Henda

“…Documenting the circulation dynamics of SARS-CoV-2 variants in different regions of the world is crucial for monitoring virus transmission worldwide and…”
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Whole-exome sequencing reveals novel variants of monogenic diabetes in Tunisia: impact on diagnosis and healthcare management by Kheriji, Nadia, Dallali, Hamza, Gouiza, Ismail, Hechmi, Meriem, Mahjoub, Faten, Mrad, Mehdi, Krir, Asma, Soltani, Manel, Trabelsi, Hajer, Hamdi, Walid, Bahlous, Afef, Ben Ahmed, Melika, Jamoussi, Henda, Kefi, Rym

“…Monogenic diabetes (MD) accounts for 3%-6% of all cases of diabetes. This prevalence is underestimated due to its overlapping clinical features with type 1 and…”
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A map of copy number variations in the Tunisian population: a valuable tool for medical genomics in North Africa by Romdhane, Lilia, Mezzi, Nessrine, Dallali, Hamza, Messaoud, Olfa, Shan, Jingxuan, Fakhro, Khalid A., Kefi, Rym, Chouchane, Lotfi, Abdelhak, Sonia

“…Copy number variation (CNV) is considered as the most frequent type of structural variation in the human genome. Some CNVs can act on human phenotype…”
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Association of HNF1A gene variants and haplotypes with metabolic syndrome: a case-control study in the Tunisian population and a meta-analysis by Dallali, Hamza, Hechmi, Meriem, Morjane, Imane, Elouej, Sahar, Jmel, Haifa, Ben Halima, Yosra, Abid, Abdelmajid, Bahlous, Afef, Barakat, Abdelhamid, Jamoussi, Henda, Abdelhak, Sonia, Kefi, Rym

“…Variants in the Hepatocyte Nuclear Factor 1 Alpha gene (HNF1A) are associated with lipoproteins levels and type 2 diabetes. In this study, we aimed to assess…”
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Using KASP technique to screen LRRK2 G2019S mutation in a large Tunisian cohort by Landoulsi, Zied, Benromdhan, Sawssan, Ben Djebara, Mouna, Damak, Mariem, Dallali, Hamza, Kefi, Rym, Abdelhak, Sonia, Gargouri-Berrechid, Amina, Mhiri, Chokri, Gouider, Riadh

“…In North African populations, G2019S mutation in LRRK2 gene, encoding for the leucine-rich repeat kinase 2, is the most prevalent mutation linked to familial…”
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Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case–Control Study and Meta-analysis by Benrahma, Houda, Charoute, Hicham, Lasram, Khaled, Boulouiz, Redouane, Atig, Rym Kefi-Ben, Fakiri, Malika, Rouba, Hassan, Abdelhak, Sonia, Barakat, Abdelhamid

“…Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations…”
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Genetic characterization of suspected MODY patients in Tunisia by targeted next-generation sequencing by Dallali, Hamza, Pezzilli, Serena, Hechmi, Meriem, Sallem, Om Kalthoum, Elouej, Sahar, Jmel, Haifa, Ben Halima, Yosra, Chargui, Mariem, Gharbi, Mariem, Mercuri, Luana, Alberico, Federica, Mazza, Tommaso, Bahlous, Afaf, Ben Ahmed, Melika, Jamoussi, Henda, Abid, Abdelmajid, Trischitta, Vincenzo, Abdelhak, Sonia, Prudente, Sabrina, Kefi, Rym

“…Aims Maturity Onset Diabetes of the Young (MODY) is a monogenic form of diabetes with autosomal dominant inheritance pattern. The diagnosis of MODY and its…”
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Mitochondrial DNA structure of an isolated Tunisian Berber population and its relationship with Mediterranean populations by Ben Halim, Nizar, Hsouna, Sana, Lasram, Khaled, Chargui, Mariem, Khemira, Laaroussi, Saidane, Rachid, Abdelhak, Sonia, Kefi, Rym

“…Background: Douiret is an isolated Berber population from South-Eastern Tunisia. The strong geographic and cultural isolation characterising this population…”
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Whole exome sequencing identifies new causative mutations in Tunisian families with non-syndromic deafness by Riahi, Zied, Bonnet, Crystel, Zainine, Rim, Louha, Malek, Bouyacoub, Yosra, Laroussi, Nadia, Chargui, Mariem, Kefi, Rym, Jonard, Laurence, Dorboz, Imen, Hardelin, Jean-Pierre, Salah, Sihem Belhaj, Levilliers, Jacqueline, Weil, Dominique, McElreavey, Kenneth, Boespflug, Odile Tanguy, Besbes, Ghazi, Abdelhak, Sonia, Petit, Christine

“…Identification of the causative mutations in patients affected by autosomal recessive non syndromic deafness (DFNB forms), is demanding due to genetic…”
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