Search Results - "Keevil, Brian G."

LC–MS/MS analysis of steroids in the clinical laboratory by Keevil, Brian G.

“…Liquid chromatography–tandem mass spectrometry (LC–MS/MS) is a powerful tool that is changing the way we analyse steroids in the clinical laboratory. It is…”
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Novel liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for measuring steroids by Keevil, Brian G., BSc, MSc, FRCPath

“…Liquid chromatography tandem mass spectrometry (LC-MS/MS) is increasingly becoming the method of choice for steroid hormone measurements due to small sample…”
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Official International Association for Therapeutic Drug Monitoring and Clinical Toxicology Guideline: Development and Validation of Dried Blood Spot-Based Methods for Therapeutic Drug Monitoring by Capiau, Sara, Veenhof, Herman, Koster, Remco A, Bergqvist, Yngve, Boettcher, Michael, Halmingh, Otto, Keevil, Brian G, Koch, Birgit C P, Linden, Rafael, Pistos, Constantinos, Stolk, Leo M, Touw, Daan J, Stove, Christophe P, Alffenaar, Jan-Willem C

“…Dried blood spot (DBS) analysis has been introduced more and more into clinical practice to facilitate Therapeutic Drug Monitoring (TDM). To assure the quality…”
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The analysis of dried blood spot samples using liquid chromatography tandem mass spectrometry by Keevil, Brian G.

“…Assays using dried blood samples have been in use for a number of years particularly for the diagnosis of inborn errors of metabolism. This sampling technique…”
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Endogenous glucocorticoid analysis by liquid chromatography–tandem mass spectrometry in routine clinical laboratories by Hawley, James M., Keevil, Brian G.

“…•A review of the clinical applications of LC–MS/MS glucocorticoid analysis.•The major endogenous glucocorticoids are discussed.•Serum, urine and salivary…”
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Prevention of Adrenal Crisis: Cortisol Responses to Major Stress Compared to Stress Dose Hydrocortisone Delivery by Prete, Alessandro, Taylor, Angela E, Bancos, Irina, Smith, David J, Foster, Mark A, Kohler, Sibylle, Fazal-Sanderson, Violet, Komninos, John, O’Neil, Donna M, Vassiliadi, Dimitra A, Mowatt, Christopher J, Mihai, Radu, Fallowfield, Joanne L, Annane, Djillali, Lord, Janet M, Keevil, Brian G, Wass, John A H, Karavitaki, Niki, Arlt, Wiebke

“…Abstract Context Patients with adrenal insufficiency require increased hydrocortisone cover during major stress to avoid a life-threatening adrenal crisis…”
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Serum Cortisol: An Up-To-Date Assessment of Routine Assay Performance by Hawley, James M, Owen, Laura J, Lockhart, Stephen J, Monaghan, Phillip J, Armston, Annie, Chadwick, Carrie A, Wilshaw, Heather, Freire, Maisa, Perry, Leslie, Keevil, Brian G

“…Accurate serum cortisol quantification is required for the correct diagnosis and management of adrenal pathologies. Presently, most laboratories use…”
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Liquid chromatography tandem mass spectrometry in the clinical laboratory by Adaway, Joanne E, Keevil, Brian G, Owen, Laura J

“…Clinical laboratory medicine has seen the introduction and evolution of liquid chromatography tandem mass spectrometry in routine clinical laboratories over…”
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High throughput LC–MS/MS method for the simultaneous analysis of multiple vitamin D analytes in serum by Jenkinson, Carl, Taylor, Angela E., Hassan-Smith, Zaki K., Adams, John S., Stewart, Paul M., Hewison, Martin, Keevil, Brian G.

“…•High throughput LC–MS/MS method to measure multiple vitamin D metabolites in serum.•SLE is an effective sample preparation method for multiple vitamin D…”
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Associations Between Sex Steroids and the Development of Metabolic Syndrome: A Longitudinal Study in European Men by Antonio, Leen, Wu, Frederick C. W, O'Neill, Terence W, Pye, Stephen R, Carter, Emma L, Finn, Joseph D, Rutter, Martin K, Laurent, Michaël R, Huhtaniemi, Ilpo T, Han, Thang S, Lean, Michael E. J, Keevil, Brian G, Pendleton, Neil, Rastrelli, Giulia, Forti, Gianni, Bartfai, Gyorgy, Casanueva, Felipe F, Kula, Krzysztof, Punab, Margus, Giwercman, Aleksander, Claessens, Frank, Decallonne, Brigitte, Vanderschueren, Dirk, The EMAS Study Group

“…Context: Low testosterone (T) has been associated with incident metabolic syndrome (MetS), but it remains unclear if this association is independent of sex…”
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Simultaneous measurement of cortisol and cortisone in human saliva using liquid chromatography–tandem mass spectrometry: Application in basal and stimulated conditions by Perogamvros, Ilias, Owen, Laura J., Newell-Price, John, Ray, David W., Trainer, Peter J., Keevil, Brian G.

“…Immunoassays used for the measurement of salivary cortisol are limited by variable interference from cortisone. Salivary cortisone is a consequence of the…”
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Steroid metabolome analysis reveals prevalent glucocorticoid excess in primary aldosteronism by Arlt, Wiebke, Lang, Katharina, Sitch, Alice J, Dietz, Anna S, Rhayem, Yara, Bancos, Irina, Feuchtinger, Annette, Chortis, Vasileios, Gilligan, Lorna C, Ludwig, Philippe, Riester, Anna, Asbach, Evelyn, Hughes, Beverly A, O'Neil, Donna M, Bidlingmaier, Martin, Tomlinson, Jeremy W, Hassan-Smith, Zaki K, Rees, D Aled, Adolf, Christian, Hahner, Stefanie, Quinkler, Marcus, Dekkers, Tanja, Deinum, Jaap, Biehl, Michael, Keevil, Brian G, Shackleton, Cedric Hl, Deeks, Jonathan J, Walch, Axel K, Beuschlein, Felix, Reincke, Martin

“…Adrenal aldosterone excess is the most common cause of secondary hypertension and is associated with increased cardiovascular morbidity. However, adverse…”
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Quantitation of aldosterone in human plasma by ultra high performance liquid chromatography tandem mass spectrometry by Hinchliffe, Edward, Carter, Stephanie, Owen, Laura J., Keevil, Brian G.

“…► We report a novel UPLC–MS/MS method for the quantitation of aldosterone from human plasma. ► Sample extraction utilises a rapid solid phase extraction…”
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Serum and plasma 5-hydroxyindoleacetic acid as an alternative to 24-h urine 5-hydroxyindoleacetic acid measurement by Adaway, Joanne E, Dobson, Rebecca, Walsh, Jennifer, Cuthbertson, Daniel J, Monaghan, Phillip J, Trainer, Peter J, Valle, Juan W, Keevil, Brian G

“…Neuroendocrine tumours are slow growing tumours known to secrete a variety of vasoactive peptides which give rise to symptoms of the carcinoid syndrome. The…”
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Association of sex hormones with physical, laboratory, and imaging markers of anthropometry in men and women from the general population by Seyfart, Tom, Friedrich, Nele, Kische, Hanna, Bülow, Robin, Wallaschofski, Henri, Völzke, Henry, Nauck, Matthias, Keevil, Brian G, Haring, Robin

“…The aim of this study was to evaluate the association of sex hormones with anthropometry in a large population-based cohort, with liquid chromatography-mass…”
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Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy by Ho, Jan Hoong, Adam, Safwaan, Azmi, Shazli, Ferdousi, Maryam, Liu, Yifen, Kalteniece, Alise, Dhage, Shaishav S, Keevil, Brian G, Syed, Akheel A, Ammori, Basil J, Ahern, Tomás, Donn, Rachelle, Malik, Rayaz A, Soran, Handrean

“…Multiple factors contribute to sexual dysfunction in men with obesity. Sex hormone levels are commonly abnormal in men with obesity and this abnormality is…”
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Simultaneous analysis of cortisol and cortisone in saliva using XLC–MS/MS for fully automated online solid phase extraction by Jones, Rachel L., Owen, Laura J., Adaway, Joanne E., Keevil, Brian G.

“…► An XLC–MS/MS assay for salivary cortisol and cortisone has been validated. ► The Spark Holland Symbiosis™ provides fully automated online solid phase…”
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Assessment of free testosterone concentration by Keevil, Brian G., Adaway, Jo

“…•Free testosterone may complement the measurement of serum T, but this is controversial and is not universally accepted.•Equilibrium dialysis methods are too…”
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State-of-the-Art of Serum Testosterone Measurement by Isotope Dilution-Liquid Chromatography- Tandem Mass Spectrometry by Thienpont, Linda M, Van Uytfanghe, Katleen, Blincko, Stuart, Ramsay, Carol S, Xie, Hui, Doss, Robert C, Keevil, Brian G, Owen, Laura J, Rockwood, Alan L, Kushnir, Mark M, Chun, Kelly Y, Chandler, Donald W, Field, Helen P, Sluss, Patrick M

“…The recent interest of clinical laboratories in developing serum testosterone assays based on isotope dilution-liquid chromatography-tandem mass spectrometry…”
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Salivary androgens in adolescence and their value as a marker of puberty: results from the SCAMP cohort by Patjamontri, Supitcha, Spiers, Alexander, Smith, Rachel B, Shen, Chen, Adaway, Jo, Keevil, Brian G, Toledano, Mireille B, Faisal Ahmed, S

“…Salivary androgens represent non-invasive biomarkers of puberty that may have utility in clinical and population studies. To understand normal age-related…”
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