Search Results - "Keeshen, Caroline M."

The Autism-Associated Gene Scn2a Contributes to Dendritic Excitability and Synaptic Function in the Prefrontal Cortex by Spratt, Perry W.E., Ben-Shalom, Roy, Keeshen, Caroline M., Burke, Kenneth J., Clarkson, Rebecca L., Sanders, Stephan J., Bender, Kevin J.

“…Autism spectrum disorder (ASD) is strongly associated with de novo gene mutations. One of the most commonly affected genes is SCN2A. ASD-associated SCN2A…”
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Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels by Burke, Kenneth J., Keeshen, Caroline M., Bender, Kevin J.

“…Neuromodulators are important regulators of synaptic transmission throughout the brain. At the presynaptic terminal, neuromodulation of calcium channels (CaVs)…”
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Serotonin enhances excitability and gamma frequency temporal integration in mouse prefrontal fast-spiking interneurons by Athilingam, Jegath C, Ben-Shalom, Roy, Keeshen, Caroline M, Sohal, Vikaas S, Bender, Kevin J

“…The medial prefrontal cortex plays a key role in higher order cognitive functions like decision making and social cognition. These complex behaviors emerge…”
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Opposing Effects on NaV1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures by Ben-Shalom, Roy, Keeshen, Caroline M., Berrios, Kiara N., An, Joon Y., Sanders, Stephan J., Bender, Kevin J.

“…Variants in the SCN2A gene that disrupt the encoded neuronal sodium channel NaV1.2 are important risk factors for autism spectrum disorder (ASD), developmental…”
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Paradoxical hyperexcitability from NaV1.2 sodium channel loss in neocortical pyramidal cells by Spratt, Perry W.E., Alexander, Ryan P.D., Ben-Shalom, Roy, Sahagun, Atehsa, Kyoung, Henry, Keeshen, Caroline M., Sanders, Stephan J., Bender, Kevin J.

“…Loss-of-function variants in the gene SCN2A, which encodes the sodium channel NaV1.2, are strongly associated with autism spectrum disorder and intellectual…”
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Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance by Schamiloglu, Selin, Lewis, Elinor, Keeshen, Caroline M., Hergarden, Anne C., Bender, Kevin J., Whistler, Jennifer L.

“…Second-generation antipsychotics (SGAs) are frontline treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not…”
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Opposing Effects on Na V 1.2 Function Underlie Differences Between SCN2A Variants Observed in Individuals With Autism Spectrum Disorder or Infantile Seizures by Ben-Shalom, Roy, Keeshen, Caroline M, Berrios, Kiara N, An, Joon Y, Sanders, Stephan J, Bender, Kevin J

“…Variants in the SCN2A gene that disrupt the encoded neuronal sodium channel Na 1.2 are important risk factors for autism spectrum disorder (ASD), developmental…”
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Arrestin-3 Agonism at Dopamine D 3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance by Schamiloglu, Selin, Lewis, Elinor, Keeshen, Caroline M, Hergarden, Anne C, Bender, Kevin J, Whistler, Jennifer L

“…Second-generation antipsychotics (SGAs) are frontline treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not…”
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Opposing effects on NaV 1.2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures by Ben-Shalom, Roy, Keeshen, Caroline M, Berrios, Kiara N, An, Joon Y, Sanders, Stephan J, Bender, Kevin J

“…Abstract Background Variants in SCN2A that disrupt the encoded neuronal sodium channel NaV 1.2 are important risk factors for autism spectrum disorder (ASD),…”
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Paradoxical hyperexcitability from Na V 1.2 sodium channel loss in neocortical pyramidal cells by Spratt, Perry W E, Alexander, Ryan P D, Ben-Shalom, Roy, Sahagun, Atehsa, Kyoung, Henry, Keeshen, Caroline M, Sanders, Stephan J, Bender, Kevin J

“…Loss-of-function variants in the gene SCN2A, which encodes the sodium channel Na 1.2, are strongly associated with autism spectrum disorder and intellectual…”
Get full text