Search Results - "Kees, Martin G"

Determination of free vancomycin, ceftriaxone, cefazolin and ertapenem in plasma by ultrafiltration: Impact of experimental conditions by Kratzer, Alexander, Liebchen, Uwe, Schleibinger, Michael, Kees, Martin G., Kees, Frieder

“…•Scientific and clinical need to determine free antibiotic for PK/PD optimisation.•Ultrafiltration is appropriate to determine free drug concentrations…”
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Protein binding characteristics and pharmacokinetics of ceftriaxone in intensive care unit patients by Schleibinger, Michael, Steinbach, Cathérine L., Töpper, Christoph, Kratzer, Alexander, Liebchen, Uwe, Kees, Frieder, Salzberger, Bernd, Kees, Martin G.

“…Aims The aim of the present study was to assess the pharmacokinetics of total and unbound ceftriaxone in intensive care unit (ICU) patients and its protein…”
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Determination of free clindamycin, flucloxacillin or tedizolid in plasma: Pay attention to physiological conditions when using ultrafiltration by Dorn, Christoph, Schießer, Selina, Wulkersdorfer, Beatrix, Hitzenbichler, Florian, Kees, Martin G., Zeitlinger, Markus

“…Pharmacokinetic/pharmacodynamic indices of anti‐infective drugs should be referenced to free drug concentrations. In the present study, clindamycin,…”
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Determination of glomerular filtration rate "en passant" after high doses of iohexol for computed tomography in intensive care medicine-a proof of concept by Dejaco, Alexander, Dorn, Christoph, Paal, Michael, Gruber, Michael, Graf, Bernhard M, Kees, Martin G

“…Accurate assessment of renal function is of great clinical and scientific importance, as it is an important pharmacokinetic covariate of pivotal drugs. The…”
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Unbound fraction of vancomycin in intensive care unit patients by Kees, Martin G., Wicha, Sebastian G., Seefeld, Astrid, Kees, Frieder, Kloft, Charlotte

“…Published data on the unbound fraction of vancomycin in patient samples exhibit high variability. In the present study, a robust ultrafiltration method was…”
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Neurocognitive Impairment After Propofol With Relevance for Neurosurgical Patients and Awake Craniotomies-A Prospective Observational Study by Zech, Nina, Seemann, Milena, Luerding, Ralf, Doenitz, Christian, Zeman, Florian, Cananoglu, Hamit, Kees, Martin G, Hansen, Ernil

“…Short-acting anesthetics are used for rapid recovery, especially for neurological testing during awake craniotomy. Extent and duration of neurocognitive…”
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The association of the anesthesiologist's academic and educational status with self-confidence, self-rated knowledge and objective knowledge in rational antibiotic application by Schneider, Frederick, Schulz, Christian M, May, Matthias, Schneider, Gerhard, Ernst, Christian, Jacob, Matthias, Zacharowski, Kai, Hachenberg, Thomas, Schmidt, Maren, Kretzschmar, Moritz, Graf, Bernhard, Kees, Martin G, Pawlik, Michael, Sander, Michael, Koch, Christian, Zoller, Michael, Heim, Markus

“…This study aimed to investigate the association of anesthetists' academic and educational status with self-confidence, self-rated knowledge and objective…”
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Variable Linezolid Exposure in Intensive Care Unit Patients-Possible Role of Drug-Drug Interactions by Töpper, Christoph, Steinbach, Cathérine L, Dorn, Christoph, Kratzer, Alexander, Wicha, Sebastian G, Schleibinger, Michael, Liebchen, Uwe, Kees, Frieder, Salzberger, Bernd, Kees, Martin G

“…Standard doses of linezolid may not be suitable for all patient groups. Intensive care unit (ICU) patients in particular may be at risk of inadequate…”
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Free serum concentrations of antibiotics determined by ultrafiltration: extensive evaluation of experimental variables by Lier, Constantin, Dejaco, Alexander, Kratzer, Alexander, Kees, Martin G, Kees, Frieder, Dorn, Christoph

“…To assess the impact of experimental conditions on free serum concentrations as determined by ultrafiltration and HPLC-DAD analysis in a wide range of…”
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Pharmacodynamic and response surface analysis of linezolid or vancomycin combined with meropenem against Staphylococcus aureus by Wicha, Sebastian G., Kees, Martin G., Kuss, Janin, Kloft, Charlotte

“…Purpose To systematically assess the impact of pharmacodynamic interactions when adding either linezolid or vancomycin to meropenem on the antibacterial…”
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Perioperative administration of cefazolin and metronidazole in obese and non-obese patients: a pharmacokinetic study in plasma and interstitial fluid by Dorn, Christoph, Petroff, David, Stoelzel, Melanie, Kees, Martin G, Kratzer, Alexander, Dietrich, Arne, Kloft, Charlotte, Zeitlinger, Markus, Kees, Frieder, Wrigge, Hermann, Simon, Philipp

“…Abstract Objectives To assess plasma and tissue pharmacokinetics of cefazolin and metronidazole in obese patients undergoing bariatric surgery and non-obese…”
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Measurement of Free Plasma Concentrations of Beta-Lactam Antibiotics: An Applicability Study in Intensive Care Unit Patients by Schießer, Selina, Hitzenbichler, Florian, Kees, Martin G., Kratzer, Alexander, Lubnow, Matthias, Salzberger, Bernd, Kees, Frieder, Dorn, Christoph

“…The antibacterial effect of antibiotics is linked to the free drug concentration. This study investigated the applicability of an ultrafiltration method to…”
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TDMx: A novel web-based open-access support tool for optimising antimicrobial dosing regimens in clinical routine by Wicha, Sebastian G, Kees, Martin G, Solms, Alexander, Minichmayr, Iris K, Kratzer, Alexander, Kloft, Charlotte

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Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial by Dorn, Christoph, Petroff, David, Neumann, Nancy, Kratzer, Alexander, El-Najjar, Nahed, Dietrich, Arne, Kloft, Charlotte, Zeitlinger, Markus, Kees, Martin G, Kees, Frieder, Wrigge, Hermann, Simon, Philipp

“…To assess the pharmacokinetics and tissue penetration of fosfomycin in obese and non-obese surgical patients. Fifteen obese patients undergoing bariatric…”
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Population pharmacokinetics of meropenem during continuous infusion in surgical ICU patients by Kees, Martin G., Minichmayr, Iris K., Moritz, Stefan, Beck, Stefanie, Wicha, Sebastian G., Kees, Frieder, Kloft, Charlotte, Steinke, Thomas

“…Continuous infusion of meropenem is a candidate strategy for optimization of its pharmacokinetic/pharmacodynamic profile. However, plasma concentrations are…”
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Unbound fraction of ertapenem in intensive care unit patients by Liebchen, Uwe, Kratzer, Alexander, Wicha, Sebastian G, Kees, Frieder, Kloft, Charlotte, Kees, Martin G

“…To determine unbound ertapenem concentrations in plasma and to describe the pharmacokinetics of unbound ertapenem in intensive care unit (ICU) patients. For…”
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Successful surgical-multimodal treatment for vaccine-induced complete splanchnic vein thrombosis after ChAdOx1 nCoV-19 vaccination by Junger, Henrik, Luerken, Lukas, Kees, Martin G, Prasser, Christopher, Scharf, Gregor, Eissnert, Christoph, Schlitt, Alexandra, Brennfleck, Frank W, Dienemann, Thomas, Graf, Bernhard M, Stroszczynski, Christian, Brunner, Stefan M, Schlitt, Hans J

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Plasma and tissue pharmacokinetics of fosfomycin in morbidly obese and non-obese surgical patients: a controlled clinical trial by Dorn, Christoph, Petroff, David, Neumann, Nancy, Kratzer, Alexander, El-Najjar, Nahed, Dietrich, Arne, Kloft, Charlotte, Zeitlinger, Markus, Kees, Martin G, Kees, Frieder, Wrigge, Hermann, Simon, Philipp

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Population pharmacokinetics and target attainment analysis of moxifloxacin in patients with diabetic foot infections by Wicha, Sebastian G., Haak, Thomas, Zink, Karl, Kees, Frieder, Kloft, Charlotte, Kees, Martin G.

“…The objective of this study was to provide a pharmacokinetic/pharmacodynamic (PK/PD) analysis of moxifloxacin in patients with diabetic foot infections (DFI)…”
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Clearance of vancomycin during continuous infusion in Intensive Care Unit patients: correlation with measured and estimated creatinine clearance and serum cystatin C by Kees, Martin G, Hilpert, Justus W, Gnewuch, Carsten, Kees, Frieder, Voegeler, Stephan

“…Abstract Vancomycin (VAN) dosing requires adjustment to renal function, which is often estimated using the Cockcroft–Gault formula; however, its precision is…”
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