Search Results - "Keener, James E."

Engineering Nanodisc Scaffold Proteins for Native Mass Spectrometry by Reid, Deseree J, Keener, James E, Wheeler, Andrew P, Zambrano, Dane Evan, Diesing, Jessica M, Reinhardt-Szyba, Maria, Makarov, Alexander, Marty, Michael T

“…Lipoprotein nanodiscs are ideally suited for native mass spectrometry because they provide a relatively monodisperse nanoscale lipid bilayer environment for…”
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Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis by Tan, Yong Zi, Rodrigues, José, Keener, James E., Zheng, Ruixiang Blake, Brunton, Richard, Kloss, Brian, Giacometti, Sabrina I., Rosário, Ana L., Zhang, Lei, Niederweis, Michael, Clarke, Oliver B., Lowary, Todd L., Marty, Michael T., Archer, Margarida, Potter, Clinton S., Carragher, Bridget, Mancia, Filippo

“…Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell…”
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Native Mass Spectrometry of Membrane Proteins by Keener, James E, Zhang, Guozhi, Marty, Michael T

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Measuring Remodeling of the Lipid Environment Surrounding Membrane Proteins with Lipid Exchange and Native Mass Spectrometry by Zhang, Guozhi, Keener, James E, Marty, Michael T

“…Due to their crucial biochemical roles, membrane proteins are important drug targets. Although it is clear that lipids can influence membrane protein function,…”
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Investigating the Lipid Selectivity of Membrane Proteins in Heterogeneous Nanodiscs by Keener, James E., Jayasekera, Hiruni S., Marty, Michael T.

“…The structure and function of membrane proteins can be significantly impacted by the surrounding lipid environment, but membrane protein–lipid interactions in…”
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Top-Down Characterization of Bacterial Lipopolysaccharides and Lipooligosaccharides Using Activated-Electron Photodetachment Mass Spectrometry by Keener, James E., Goh, Byoungsook, Yoo, Ji-Sun, Oh, Sungwhan F., Brodbelt, Jennifer S.

“…Lipopolysaccharides (LPS) and lipooligosaccharides (LOS) are located in the outer membrane of Gram-negative bacteria and are comprised of three distinctive…”
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Structural basis of omega-3 fatty acid transport across the blood–brain barrier by Cater, Rosemary J., Chua, Geok Lin, Erramilli, Satchal K., Keener, James E., Choy, Brendon C., Tokarz, Piotr, Chin, Cheen Fei, Quek, Debra Q. Y., Kloss, Brian, Pepe, Joseph G., Parisi, Giacomo, Wong, Bernice H., Clarke, Oliver B., Marty, Michael T., Kossiakoff, Anthony A., Khelashvili, George, Silver, David L., Mancia, Filippo

“…Docosahexaenoic acid is an omega-3 fatty acid that is essential for neurological development and function, and it is supplied to the brain and eyes…”
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Chemical Additives Enable Native Mass Spectrometry Measurement of Membrane Protein Oligomeric State within Intact Nanodiscs by Keener, James E, Zambrano, Dane Evan, Zhang, Guozhi, Zak, Ciara K, Reid, Deseree J, Deodhar, Bhushan S, Pemberton, Jeanne E, Prell, James S, Marty, Michael T

“…Membrane proteins play critical biochemical roles but remain challenging to study. Recently, native or nondenaturing mass spectrometry (MS) has made great…”
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Imidazole Derivatives Improve Charge Reduction and Stabilization for Native Mass Spectrometry by Townsend, Julia A, Keener, James E, Miller, Zachary M, Prell, James S, Marty, Michael T

“…Noncovalent interactions between biomolecules are critical to their activity. Native mass spectrometry (MS) has enabled characterization of these interactions…”
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Dissecting the role of the CRMP2–neurofibromin complex on pain behaviors by Moutal, Aubin, Wang, Yue, Yang, Xiaofang, Ji, Yingshi, Luo, Shizhen, Dorame, Angie, Bellampalli, Shreya S., Chew, Lindsey A., Cai, Song, Dustrude, Erik T., Keener, James E., Marty, Michael T., Vanderah, Todd W., Khanna, Rajesh

“…Neurofibromatosis type 1 (NF1), a genetic disorder linked to inactivating mutations or a homozygous deletion of the Nf1 gene, is characterized by…”
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Top-down mass spectrometry of native proteoforms and their complexes: a community study by Habeck, Tanja, Brown, Kyle A, Des Soye, Benjamin, Lantz, Carter, Zhou, Mowei, Alam, Novera, Hossain, Md Amin, Jung, Wonhyeuk, Keener, James E, Volny, Michael, Wilson, Jesse W, Ying, Yujia, Agar, Jeffrey N, Danis, Paul O, Ge, Ying, Kelleher, Neil L, Li, Huilin, Loo, Joseph A, Marty, Michael T, Paša-Tolić, Ljiljana, Sandoval, Wendy, Lermyte, Frederik

“…The combination of native electrospray ionization with top-down fragmentation in mass spectrometry (MS) allows simultaneous determination of the stoichiometry…”
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Native mass spectrometry reveals the simultaneous binding of lipids and zinc to rhodopsin by Norris, Carolanne E., Keener, James E., Perera, Suchithranga M.D.C., Weerasinghe, Nipuna, Fried, Steven D.E., Resager, William C., Rohrbough, James G., Brown, Michael F., Marty, Michael T.

“…Rhodopsin, a prototypical G-protein-coupled receptor, is responsible for scoptic vision at low-light levels. Although rhodopsin’s photoactivation cascade is…”
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Rapid LC–MS Method for Accurate Molecular Weight Determination of Membrane and Hydrophobic Proteins by Lippens, Jennifer L, Egea, Pascal F, Spahr, Chris, Vaish, Amit, Keener, James E, Marty, Michael T, Loo, Joseph A, Campuzano, Iain D. G

“…Therapeutic target characterization involves many components, including accurate molecular weight (MW) determination. Knowledge of the accurate MW allows one…”
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Polyproline peptide targets Klebsiella pneumoniae polysaccharides to collapse biofilms by De los Santos, Laura, Beckman, Robert L., DeBarro, Christina, Keener, James E., Torres, Marcelo D.T., Fuente-Nunez, Cesar de la, Brodbelt, Jennifer S., Fleeman, Renee M.

“…Hypervirulent Klebsiella pneumoniae is known for its increased extracellular polysaccharide production. Biofilm matrices of hypervirulent K. pneumoniae have…”
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Measuring Membrane Protein-Lipid Interactions in Nanodiscs with Native Mass Spectrometry by Keener, James E., Townsend, Julia, Mowad, Megan, Marty, Michael T.

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Investigating the Influences of Lipid Binding on Rhodopsin Activation using Native Mass Spectrometry by Norris, Carolanne E., Keener, James E., Weerasinghe, Nipuna, Brown, Michael F., Marty, Michael T.

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Characterizing the Lipid Annulus Surrounding Membrane Proteins with Native Mass Spectrometry of Nanodiscs by Keener, James E., Reid, Deseree J., Evan Zambrano, Dane, Zak, Ciara, Marty, Michael T.

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