Search Results - "Keene, R."

Rapid fabrication of vascularized and innervated cell-laden bone models with biomimetic intrafibrillar collagen mineralization by Thrivikraman, Greeshma, Athirasala, Avathamsa, Gordon, Ryan, Zhang, Limin, Bergan, Raymond, Keene, Douglas R., Jones, James M., Xie, Hua, Chen, Zhiqiang, Tao, Jinhui, Wingender, Brian, Gower, Laurie, Ferracane, Jack L., Bertassoni, Luiz E.

“…Bone tissue, by definition, is an organic–inorganic nanocomposite, where metabolically active cells are embedded within a matrix that is heavily calcified on…”
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Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing by Howell, Kristen, Chien, Chun, Bell, Rebecca, Laudier, Damien, Tufa, Sara F., Keene, Douglas R., Andarawis-Puri, Nelly, Huang, Alice H.

“…To date, the cell and molecular mechanisms regulating tendon healing are poorly understood. Here, we establish a novel model of tendon regeneration using…”
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Conversion of Mechanical Force into TGF-β-Mediated Biochemical Signals by Maeda, Toru, Sakabe, Tomoya, Sunaga, Ataru, Sakai, Keiko, Rivera, Alexander L., Keene, Douglas R., Sasaki, Takako, Stavnezer, Edward, Iannotti, Joseph, Schweitzer, Ronen, Ilic, Dusko, Baskaran, Harihara, Sakai, Takao

“…Mechanical forces influence homeostasis in virtually every tissue [1, 2]. Tendon, constantly exposed to variable mechanical force, is an excellent model in…”
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In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial by Gurevich, Irina, Agarwal, Pooja, Zhang, PeiPei, Dolorito, John A., Oliver, Stacie, Liu, Henry, Reitze, Nicholas, Sarma, Nikhil, Bagci, Isin Sinem, Sridhar, Kunju, Kakarla, Visesha, Yenamandra, Vamsi K., O’Malley, Mark, Prisco, Marco, Tufa, Sara F., Keene, Douglas R., South, Andrew P., Krishnan, Suma M., Marinkovich, M. Peter

“…Recessive dystrophic epidermolysis bullosa (RDEB) is a lifelong genodermatosis associated with blistering, wounding, and scarring caused by mutations in COL7A1…”
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QR-313, an Antisense Oligonucleotide, Shows Therapeutic Efficacy for Treatment of Dominant and Recessive Dystrophic Epidermolysis Bullosa: A Preclinical Study by Bornert, Olivier, Hogervorst, Marieke, Nauroy, Pauline, Bischof, Johannes, Swildens, Jim, Athanasiou, Ioannis, Tufa, Sara F., Keene, Douglas R., Kiritsi, Dimitra, Hainzl, Stefan, Murauer, Eva M., Marinkovich, M. Peter, Platenburg, Gerard, Hausser, Ingrid, Wally, Verena, Ritsema, Tita, Koller, Ulrich, Haisma, Elisabeth M., Nyström, Alexander

“…Dystrophic epidermolysis bullosa (DEB) is a blistering skin disease caused by mutations in the gene COL7A1 encoding collagen VII. DEB can be inherited as…”
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Tgfβ signaling is critical for maintenance of the tendon cell fate by Tan, Guak-Kim, Pryce, Brian A, Stabio, Anna, Brigande, John V, Wang, ChaoJie, Xia, Zheng, Tufa, Sara F, Keene, Douglas R, Schweitzer, Ronen

“…Studies of cell fate focus on specification, but little is known about maintenance of the differentiated state. In this study, we find that the mouse tendon…”
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Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons by Murchison, Nicholas D, Price, Brian A, Conner, David A, Keene, Douglas R, Olson, Eric N, Tabin, Clifford J, Schweitzer, Ronen

“…The scleraxis ( Scx ) gene, encoding a bHLH transcription factor, is expressed in the progenitors and cells of all tendon tissues. To determine Scx function,…”
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Bone Marrow Transplantation for Recessive Dystrophic Epidermolysis Bullosa by Wagner, John E, Ishida-Yamamoto, Akemi, McGrath, John A, Hordinsky, Maria, Keene, Douglas R, Woodley, David T, Chen, Mei, Riddle, Megan J, Osborn, Mark J, Lund, Troy, Dolan, Michelle, Blazar, Bruce R, Tolar, Jakub

“…The use of marrow stem cells to treat seven children with severe epidermolysis bullosa caused by loss-of-function mutations in COL7A, the gene encoding type…”
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Microenvironmental regulation by fibrillin-1 by Sengle, Gerhard, Tsutsui, Ko, Keene, Douglas R, Tufa, Sara F, Carlson, Eric J, Charbonneau, Noe L, Ono, Robert N, Sasaki, Takako, Wirtz, Mary K, Samples, John R, Fessler, Liselotte I, Fessler, John H, Sekiguchi, Kiyotoshi, Hayflick, Susan J, Sakai, Lynn Y

“…Fibrillin-1 is a ubiquitous extracellular matrix molecule that sequesters latent growth factor complexes. A role for fibrillin-1 in specifying tissue…”
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Creation and characterization of novel rat model for recessive dystrophic epidermolysis bullosa: Frameshift mutation of the Col7a1 gene leads to severe blistered phenotype by Stone, William, Strege, Chloe, Miller, William, Geurts, Aron M, Grzybowski, Michael, Riddle, Megan, Lees, Christopher, Eide, Cindy, Keene, Douglas R, Tufa, Sara F, Seelig, Davis, McGrath, John, Tolar, Jakub

“…Recessive dystrophic epidermolysis bullosa is a rare genodermatosis caused by a mutation of the Col7a1 gene. The Col7a1 gene codes for collagen type VII…”
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The Fraser Complex Proteins (Frem1, Frem2, and Fras1) Can Form Anchoring Cords in the Absence of AMACO at the Dermal-Epidermal Junction of Mouse Skin by Esho, Temitope, Kobbe, Birgit, Tufa, Sara F, Keene, Douglas R, Paulsson, Mats, Wagener, Raimund

“…AMACO (VWA2 protein), secreted by epithelial cells, is strongly expressed at basement membranes when budding or invagination occurs in embryos. In skin, AMACO…”
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Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice by Sengle, Gerhard, Carlberg, Valerie, Tufa, Sara F, Charbonneau, Noe L, Smaldone, Silvia, Carlson, Eric J, Ramirez, Francesco, Keene, Douglas R, Sakai, Lynn Y

“…Fibrillins are large extracellular macromolecules that polymerize to form the backbone structure of connective tissue microfibrils. Mutations in the gene for…”
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Collagen XII and XIV, New Partners of Cartilage Oligomeric Matrix Protein in the Skin Extracellular Matrix Suprastructure by Agarwal, Pallavi, Zwolanek, Daniela, Keene, Douglas R., Schulz, Jan-Niklas, Blumbach, Katrin, Heinegård, Dick, Zaucke, Frank, Paulsson, Mats, Krieg, Thomas, Koch, Manuel, Eckes, Beate

“…The tensile and scaffolding properties of skin rely on the complex extracellular matrix (ECM) that surrounds cells, vasculature, nerves, and adnexus structures…”
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Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis by Iwasaki, Ayumi, Sakai, Keiko, Moriya, Kei, Sasaki, Takako, Keene, Douglas R., Akhtar, Riaz, Miyazono, Takayoshi, Yasumura, Satoshi, Watanabe, Masatoshi, Morishita, Shin, Sakai, Takao

“…Fibrosis is characterized by extracellular matrix (ECM) remodeling and stiffening. However, the functional contribution of tissue stiffening to noncancer…”
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Bone marrow transplant with post‐transplant cyclophosphamide for recessive dystrophic epidermolysis bullosa expands the related donor pool and permits tolerance of nonhaematopoietic cellular grafts by Ebens, C.L., McGrath, J.A., Tamai, K., Hovnanian, A., Wagner, J.E., Riddle, M.J., Keene, D.R., DeFor, T.E., Tryon, R., Chen, M., Woodley, D.T., Hook, K., Tolar, J.

“…Summary Background Recessive dystrophic epidermolysis bullosa (RDEB) is a severe systemic genodermatosis lacking therapies beyond supportive care for its…”
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Loss of Smad4 in the scleraxis cell lineage results in postnatal joint contracture by Schlesinger, Saundra Y., Seo, Seongkyung, Pryce, Brian A., Tufa, Sara F., Keene, Douglas R., Huang, Alice H., Schweitzer, Ronen

“…Growth of the musculoskeletal system requires precise coordination between bone, muscle, and tendon during development. Insufficient elongation of the…”
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Musculoskeletal integration at the wrist underlies the modular development of limb tendons by Huang, Alice H, Riordan, Timothy J, Pryce, Brian, Weibel, Jennifer L, Watson, Spencer S, Long, Fanxin, Lefebvre, Veronique, Harfe, Brian D, Stadler, H Scott, Akiyama, Haruhiko, Tufa, Sara F, Keene, Douglas R, Schweitzer, Ronen

“…The long tendons of the limb extend from muscles that reside in the zeugopod (arm/leg) to their skeletal insertions in the autopod (paw). How these connections…”
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The Atypical Homeodomain Transcription Factor Mohawk Controls Tendon Morphogenesis by Liu, Wenjin, Watson, Spencer S., Lan, Yu, Keene, Douglas R., Ovitt, Catherine E., Liu, Han, Schweitzer, Ronen, Jiang, Rulang

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Perspectives of Complementary and Alternative Medicine use by cancer patients in a regional hospital in North Queensland, Australia by Keene, Martin R., Heslop, Ian M., Sabesan, Sabe S., Glass, Beverley D.

“…This study aimed to investigate CAMs used, and reasons for and disclosure of this use by cancer patients in a regional hospital in North Queensland, Australia…”
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Sex, pregnancy and aortic disease in Marfan syndrome by Renard, Marjolijn, Muiño-Mosquera, Laura, Manalo, Elise C, Tufa, Sara, Carlson, Eric J, Keene, Douglas R, De Backer, Julie, Sakai, Lynn Y

“…Sex-related differences as well as the adverse effect of pregnancy on aortic disease outcome are well-established phenomena in humans with Marfan syndrome…”
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