Search Results - "Keene, B. W."

Effect of Pimobendan in Dogs with Preclinical Myxomatous Mitral Valve Disease and Cardiomegaly: The EPIC Study—A Randomized Clinical Trial by Boswood, A., Häggström, J., Gordon, S.G., Wess, G., Stepien, R.L., Oyama, M.A., Keene, B.W., Bonagura, J., MacDonald, K.A., Patteson, M., Smith, S., Fox, P.R., Sanderson, K., Woolley, R., Szatmári, V., Menaut, P., Church, W.M., O'Sullivan, M. L., Jaudon, J.‐P., Kresken, J.‐G., Rush, J., Barrett, K.A., Rosenthal, S.L., Saunders, A.B., Ljungvall, I., Deinert, M., Bomassi, E., Estrada, A.H., Fernandez Del Palacio, M.J., Moise, N.S., Abbott, J.A., Fujii, Y., Spier, A., Luethy, M.W., Santilli, R.A., Uechi, M., Tidholm, A., Watson, P.

“…Background Pimobendan is effective in treatment of dogs with congestive heart failure (CHF) secondary to myxomatous mitral valve disease (MMVD). Its effect on…”
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Pathology of End-stage Remodeling in a Family of Cats with Hypertrophic Cardiomyopathy by Cesta, M. F, Baty, C. J, Keene, B. W, Smoak, I. W, Malarkey, D. E

“…End-stage hypertrophic cardiomyopathy (ES-HCM), affecting 5-10% of human hypertrophic cardiomyopathy (HCM) patients, is characterized by relative thinning of…”
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Cardiac structure and function in female carriers of a canine model of Duchenne muscular dystrophy by Kane, A.M., DeFrancesco, T.C., Boyle, M.C., Malarkey, D.E., Ritchey, J.W., Atkins, C.E., Cullen, J.M., Kornegay, J.N., Keene, B.W.

“…This investigation tested the hypothesis that carriers of golden retriever muscular dystrophy (GRMD), a genetically homologous condition of Duchenne muscular…”
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Dilated cardiomyopathy in 151 Irish Wolfhounds: Characteristic clinical findings, life expectancy and causes of death by Vollmar, C., Vollmar, A., Keene, B.W., Fox, P.R., Reese, S., Kohn, B.

“…•Irish Wolfhounds have a high prevalence of familial dilated cardiomyopathy.•Other common disease predispositions adversely affect life expectancy in Irish…”
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Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy by O'Donnell, K., Adin, D., Atkins, C. E., DeFrancesco, T., Keene, B. W., Tou, S., Meurs, K. M.

“…Summary Hypertrophic cardiomyopathy (HCM) is the most common cause of heart disease in the domestic cat with a genetic predisposition in a few breeds. In the…”
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Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure by Walker, A.L., DeFrancesco, T.C., Bonagura, J.D., Keene, B.W., Meurs, K.M., Tou, S.P., Kurtz, K., Aona, B., Barron, L., McManamey, A., Robertson, J., Adin, D.B.

“…Dilated cardiomyopathy (DCM) in dogs has been associated with feeding of grain-free (GF), legume-rich diets. Some dogs with presumed diet-associated DCM have…”
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Longitudinal Analysis of Quality of Life, Clinical, Radiographic, Echocardiographic, and Laboratory Variables in Dogs with Preclinical Myxomatous Mitral Valve Disease Receiving Pimobendan or Placebo: The EPIC Study by Boswood, A., Gordon, S.G., Häggström, J., Wess, G., Stepien, R.L., Oyama, M.A., Keene, B.W., Bonagura, J., MacDonald, K.A., Patteson, M., Smith, S., Fox, P.R., Sanderson, K., Woolley, R., Szatmári, V., Menaut, P., Church, W.M., O'Sullivan, M.L., Jaudon, J.‐P., Kresken, J.‐G., Rush, J., Barrett, K.A., Rosenthal, S.L., Saunders, A.B., Ljungvall, I., Deinert, M., Bomassi, E., Estrada, A.H., Fernandez Del Palacio, M.J., Moise, N.S., Abbott, J.A., Fujii, Y., Spier, A., Luethy, M.W., Santilli, R.A., Uechi, M., Tidholm, A., Schummer, C., Watson, P.

“…Background Changes in clinical variables associated with the administration of pimobendan to dogs with preclinical myxomatous mitral valve disease (MMVD) and…”
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Holter monitoring demonstrates that ventricular arrhythmias are common in cats with decompensated and compensated hypertrophic cardiomyopathy by Bartoszuk, U., Keene, B.W., Baron Toaldo, M., Pereira, N., Summerfield, N., Novo Matos, J., Glaus, T.M.

“…•Ventricular arrhythmias occurred at similar frequencies in cats with compensated and decompensated hypertrophic cardiomyopathy (HCM).•Plasma serum cardiac…”
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Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration by Meurs, K.M., Friedenberg, S.G., Williams, B., Keene, B.W., Atkins, C.E., Adin, D., Aona, B., DeFrancesco, T., Tou, S., Mackay, T.

“…•We hypothesized that a mutation associated with human mitral valve disease (MMVD) is associated with canine disease.•Sequenced DNA of MMVD Cavalier King…”
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Myxomatous mitral valve disease in the miniature poodle: A retrospective study by Meurs, K.M., Adin, D., O’Donnell, K., Keene, B.W., Atkins, C.E., DeFrancesco, T., Tou, S.

“…•Mxyomatous mitral valve degeneration (MMVD) in the miniature poodle was characterized.•Medical records from 32 miniature poodles with MMVD diagnosed at a…”
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Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs by Meurs, K.M., Stern, J.A., Sisson, D.D., Kittleson, M.D., Cunningham, S.M., Ames, M.K., Atkins, C.E., DeFrancesco, T., Hodge, T.E., Keene, B.W., Reina Doreste, Y., Leuthy, M., Motsinger-Reif, A.A., Tou, S.P.

“…BACKGROUND: Myocardial disease in the Boxer dog is characterized by 1 of 2 clinical presentations, dilated cardiomyopathy (DCM) characterized by ventricular…”
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Atenolol in cats with subclinical hypertrophic cardiomyopathy: a double-blind, placebo-controlled, randomized clinical trial of effect on quality of life, activity, and cardiac biomarkers by Coleman, A.E., DeFrancesco, T.C., Griffiths, E.H., Lascelles, B.D.X., Kleisch, D.J., Atkins, C.E., Keene, B.W.

“…To compare quality of life (QOL) and activity measures between healthy control cats and cats with subclinical hypertrophic cardiomyopathy (HCM), and to…”
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Towards evidence-based veterinary medicine by Keene, B W

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Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs by Lantis, A. C., Ames, M. K., Atkins, C. E., DeFrancesco, T. C., Keene, B. W., Werre, S. R.

“…Pilot studies in our laboratory revealed that furosemide‐induced renin‐angiotensin‐aldosterone system (RAAS) activation was not attenuated by the subsequent…”
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Complication Rates Associated with Transvenous Pacemaker Implantation in Dogs with High‐Grade Atrioventricular Block Performed During versus After Normal Business Hours by Ward, J.L., DeFrancesco, T.C., Tou, S.P., Atkins, C.E., Griffith, E.H., Keene, B.W.

“…Background Transvenous pacemaker implantation in dogs is associated with a relatively high complication rate. At our institution, pacemaker implantation in…”
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Multicenter Evaluation of Plasma N-Terminal Probrain Natriuretic Peptide (NT-pro BNP) as a Biochemical Screening Test for Asymptomatic (occult) Cardiomyopathy in Cats by Fox, P.R., Rush, J.E., Reynolds, C.A., DeFrancesco, T.C., Keene, B.W., Atkins, C.E., Gordon, S.G., Schober, K.E., Bonagura, J.D., Stepien, R.L., Kellihan, H.B., MacDonald, K.A., Lehmkuhl, L.B., Nguyenba, T.P., Sydney Moise, N., Lefbom, B.K., Hogan, D.F., Oyama, M.A.

“…Background: B‐type natriuretic peptide concentrations reliably distinguish between cardiac and respiratory causes of dyspnea, but its utility to detect…”
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Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002–2014) by Ward, J.L., DeFrancesco, T.C., Tou, S.P., Atkins, C.E., Griffith, E.H., Keene, B.W.

“…To evaluate the clinical presentation, diagnosis, treatment, and outcomes of a group of dogs with sinoatrial node abnormalities. Ninety-three client-owned dogs…”
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Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc by Hamlin, R.L, Cruze, C.A, Mittelstadt, S.W, Kijtawornrat, A, Keene, B.W, Roche, B.M, Nakayama, T, Nakayama, H, Hamlin, D.M, Arnold, T

“…Introduction: The purpose of this study was to determine the sensitivity and specificity for predicting the liability of a compound to lengthen QTc using…”
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Assessment of drug-induced QT interval prolongation in conscious rabbits by Kijtawornrat, A., Ozkanlar, Y., Keene, B.W., Roche, B.M., Hamlin, D.M., Hamlin, R.L.

“…Most preclinical trials are designed to identify potential torsadogenicity test only for surrogates of torsade de pointes, most commonly prolongation of the…”
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Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion by Nolan, M.W., Arkans, M.M., LaVine, D., DeFrancesco, T., Myers, J.A., Griffith, E.H., Posner, L.P., Keene, B.W., Tou, S.P., Gieger, T.L.

“…To determine the short-term safety and biologic activity of radiation therapy (RT) for presumptive cardiac hemangiosarcoma in pet dogs. Six dogs with…”
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