Search Results - "Keenan, Ryan J"

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy by Jiao, Haihan, Downie, Laura E, Huang, Xin, Wu, Mengliang, Oberrauch, Sara, Keenan, Ryan J, Jacobson, Laura H, Chinnery, Holly R

“…Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alzheimer's disease (AD). Although AD is…”
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The social defeat/overcrowding murine psychosocial stress model results in a pharmacologically reversible body weight gain but not depression - related behaviours by Keenan, Ryan J., Chan, Jacky, Donnelly, Paul S., Barnham, Kevin J., Jacobson, Laura H.

“…Depression is a highly prevalent psychiatric disorder, yet its etiology is not well understood. The validation of animal models is therefore a critical step…”
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Orexin Receptor Antagonism: Normalizing Sleep Architecture in Old Age and Disease by Kron, Jarrah O.-Z.J, Keenan, Ryan J, Hoyer, Daniel, Jacobson, Laura H

“…Sleep is essential for human well-being, yet the quality and quantity of sleep reduce as age advances. Older persons (>65 years old) are more at risk of…”
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Differential sleep/wake response and sex differences following acute suvorexant, MK‐1064 and zolpidem administration in the rTg4510 mouse model of tauopathy by Keenan, Ryan J., Daykin, Heather, Chu, Jiahui, Cornthwaite‐Duncan, Linda, Allocca, Giancarlo, Hoyer, Daniel, Jacobson, Laura H.

“…Background and Purpose Transgenic mouse models of tauopathy display prominent sleep/wake disturbances which manifest primarily as a hyperarousal phenotype…”
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Orexin 2 receptor antagonism sex‐dependently improves sleep/wakefulness and cognitive performance in tau transgenic mice by Keenan, Ryan J., Daykin, Heather, Metha, Jeremy, Cornthwaite‐Duncan, Linda, Wright, David K., Clarke, Kyra, Oberrauch, Sara, Brian, Maddison, Stephenson, Sarah, Nowell, Cameron J., Allocca, Giancarlo, Barnham, Kevin J., Hoyer, Daniel, Jacobson, Laura H.

“…Background and Purpose Tau pathology contributes to a bidirectional relationship between sleep disruption and neurodegenerative disease. Tau transgenic rTg4510…”
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Altered EEG power spectrum, but not sleep-wake architecture, in HCN1 knockout mice by Bleakley, Lauren E., Keenan, Ryan J., Graven, Rachel D., Metha, Jeremy A., Ma, Sherie, Daykin, Heather, Cornthwaite-Duncan, Linda, Hoyer, Daniel, Reid, Christopher A., Jacobson, Laura H.

“…Sleep is a complex biological state characterized by large populations of neurons firing in a rhythmic or synchronized manner. HCN channels play a critical…”
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The distribution of Hypocretin/Orexin receptor mRNA in the mouse and human brain by Mir, Sanjida, Keenan, Ryan J., Bron, Romke, Nowell, Cameron J., McLean, Catriona, Beauchamp, Leah C., Vella, Laura J., Dean, Brian, Hoyer, Daniel, Jacobson, Laura H.

“…Hypocretin (Hcrtr, HCRTR) / orexin (OX) receptors modulate a range of neurobiological functions and are drug targets for several disorders. Mapping the…”
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