Search Results - "Keenan, Russell D."

Ataxia telangiectasia mutated–deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage by Stankovic, Tatjana, Stewart, Grant S., Fegan, Christopher, Biggs, Paul, Last, James, Byrd, Philip J., Keenan, Russell D., Moss, Paul A.H., Taylor, Alexander M.R.

“…B-cell chronic lymphocytic leukemia (B-CLL) is a heterogeneous disease involving more than one molecular mechanism that leads to the transformation of CD5+ B…”
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CCL21 and Dendritic Cell Suppression in Paediatric B Cell Acute Lymphoblastic Leukaemia by Keenan, Russell D, Phillips, Kate LE

“…Despite the accumulation of genetic mutations likely to generate antigenic neoepitopes, acute lymphoblastic leukaemia (ALL) cells are poor at eliciting…”
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Single Centre Audit of Testicular Examination Practice in Children with Acute Lymphoblastic Leukaemia by Wardach, Isobelle, Aslam, Aisha, Keenan, Russell D

“…Introduction The second commonest site of extramedullary relapse in boys with acute lymphoblastic leukaemia (ALL) is the testes. As therapy stratifications…”
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Minimising Transfusion Therapy and Alloimmunisation in Patients with Sickle Cell Disorder in the Era of Hydroxyurea by Smith, Louise, Stead, Lucy, Keenan, Russell D, Thangavelu, Rekha

“…In the UK, 700 patients with sickle cell disease are on a transfusion programme1. Red blood cell (RBC) AI occurs in 4.4-76%2 of regularly transfused sickle…”
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No Demonstrable Benefit of Penicillin in a Vaccinated Population of Children with Sickle Cell Disorder by Smith, Louise, Ryan, Elizabeth, Keenan, Russell D, Thangavelu, Rekha

“…UK and many National guidelines advise on the use of prophylactic antibiotics, immunisation and patient education to minimise the risk of severe infections by…”
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Geophagia: A Scientific Approach to a Historical Practice to Sustainably Treat Endemic Iron Deficiency in a Rural Community in Nepal by Lama, Binay, Jones, Rachael, Barlow, Nicola, Keenan, Russell D

“…Geophagia is the practice of eating earth or clay and is nearly universal around the world in traditional rural societies. Many animals across genera are known…”
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Hydroxyurea Therapy for Sickle Cell Disorders in Childhood: Adherence to Therapy Transforms Lives and Needs to be the Focus - the Experience of Alder Hey Children's Hospital by Smith, Louise, Phillips, Kate L E, Keenan, Russell D

“…Following Baby HUG trial results and other recent publications it is recommended by US evidence based guidance (NHLBI, 2014) that all children with sickle cell…”
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Hyperhaemolysis in Sickle Cell Disease Is Not Necessarily a Transfusion Reaction by Jones, Elizabeth A, Smith, Louise, Keenan, Russell D

“…Hyperhaemolysis is a rare life threatening complication in sickle cell disease with rapidly dropping haemoglobin, intravascular haemolysis and haemoglobinuria…”
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Hydroxyurea Therapy Prevents High Risk Trans-Cranial Doppler Development in Children with Sickle Cell Disorders by Karpha, Indrani, Smith, Louise, Abernathy, Lawrence, Phillips, Kate LE, Keenan, Russell D

“…▪ Annual evaluation by Trans-Cranial Doppler (TCD) of cerebral artery blood flow is useful for determining stroke risk in children with sickle cell disease…”
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Stopping Folic Acid Supplementation in Hydroxyurea Treated Children with Sickle Cell Disease by Smith, Louise, Littler, Amy, Phillips, Kate LE, Keenan, Russell D

“…Daily folic acid supplementation for all children with sickle cell disorders is a widely used preventative measure in UK practice. However, a Cochrane review…”
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Factor VIII gene (F8) mutation and risk of inhibitor development in nonsevere hemophilia A by Eckhardt, Corien L., van Velzen, Alice S., Peters, Marjolein, Astermark, Jan, Brons, Paul P., Castaman, Giancarlo, Cnossen, Marjon H., Dors, Natasja, Escuriola-Ettingshausen, Carmen, Hamulyak, Karly, Hart, Daniel P., Hay, Charles R.M., Haya, Saturnino, van Heerde, Waander L., Hermans, Cedric, Holmström, Margareta, Jimenez-Yuste, Victor, Keenan, Russell D., Klamroth, Robert, Laros-van Gorkom, Britta A.P., Leebeek, Frank W.G., Liesner, Ri, Mäkipernaa, Anne, Male, Christoph, Mauser-Bunschoten, Evelien, Mazzucconi, Maria G., McRae, Simon, Meijer, Karina, Mitchell, Michael, Morfini, Massimo, Nijziel, Marten, Oldenburg, Johannes, Peerlinck, Kathelijne, Petrini, Pia, Platokouki, Helena, Reitter-Pfoertner, Sylvia E., Santagostino, Elena, Schinco, Piercarla, Smiers, Frans J., Siegmund, Berthold, Tagliaferri, Annarita, Yee, Thynn T., Kamphuisen, Pieter Willem, van der Bom, Johanna G., Fijnvandraat, Karin

“…Neutralizing antibodies (inhibitors) toward factor VIII form a severe complication in nonsevere hemophilia A, profoundly aggravating the bleeding pattern…”
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Potential for Dendritic Cell Stimulated De Novo Anti-Leukaemia CD4 T Cell Response in the Bone Marrow Tumour Microenvironment during Induction Chemotherapy by Phillips, Kate L E, Dean, Joanne E, Flanagan, Brian F, Christmas, Steve E, Keenan, Russell D

“…In acute lymphoblastic leukaemia (ALL), T cell anergy induced by tumour antigen presentation without co-stimulation contributes to immunological escape and…”
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Normal Lymphocytes at Diagnosis and during Induction Chemotherapy in Childhood Acute Lymphoblastic Leukaemia in Peripheral Blood and Bone Marrow Are Predominantly CD3+, CD4+ or CD8+, CCR7+, CD45RA+, HLA-DR by Phillips, Kate L E, Christmas, Steve E, Flanagan, Brian F, Keenan, Russell D

“…Tumour immune surveillance requires both the recognition of malignant cells as immunogenic and the functional cytotoxic capacity of an effector cell. Key…”
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Application of Human Immunophenotyping Consortium Panels to Early Childhood Leukaemia; From Diagnosis to End of Induction Chemotherapy by Phillips, Kate L E, Christmas, Steve E, Flanagan, Brian F, Keenan, Russell D

“…Perturbations in haematopoiesis are characteristic in acute leukaemia. The disturbed bone marrow (BM) microenvironment that results from high concentrations of…”
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Intensity of factor VIII treatment and the development of inhibitors in non‐severe hemophilia A patients: results of the INSIGHT case–control study by Velzen, A. S., Eckhardt, C. L., Peters, M., Leebeek, F. W. G., Escuriola‐Ettingshausen, C., Hermans, C., Keenan, R., Astermark, J., Male, C., Peerlinck, K., Cessie, S., Bom, J. G., Fijnvandraat, K.

“…Essentials Research suggests that intensive treatment episodes may increase the risk to develop inhibitors. We performed an international nested case‐control…”
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