Search Results - "Keenan, Robert"

The biology of urate by Keenan, Robert T.

“…Urate is the end-product of the purine metabolism in humans. The dominant source of urate is endogenous purines and the remainder comes through diet…”
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The mechanisms of integral membrane protein biogenesis by Hegde, Ramanujan S., Keenan, Robert J.

“…Roughly one quarter of all genes code for integral membrane proteins that are inserted into the plasma membrane of prokaryotes or the endoplasmic reticulum…”
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Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation by Itakura, Eisuke, Zavodszky, Eszter, Shao, Sichen, Wohlever, Matthew L., Keenan, Robert J., Hegde, Ramanujan S.

“…We investigated how mitochondrial membrane proteins remain soluble in the cytosol until their delivery to mitochondria or degradation at the proteasome. We…”
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Substrate-driven assembly of a translocon for multipass membrane proteins by Sundaram, Arunkumar, Yamsek, Melvin, Zhong, Frank, Hooda, Yogesh, Hegde, Ramanujan S., Keenan, Robert J.

“…Most membrane proteins are synthesized on endoplasmic reticulum (ER)-bound ribosomes docked at the translocon, a heterogeneous ensemble of transmembrane…”
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Tail-anchored membrane protein insertion into the endoplasmic reticulum by Hegde, Ramanujan S., Keenan, Robert J.

“…Key Points Tail-anchored (TA) proteins are a diverse and functionally important class of membrane proteins that are targeted to the endoplasmic reticulum (ER)…”
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A structural perspective on tail-anchored protein biogenesis by the GET pathway by Mateja, Agnieszka, Keenan, Robert J

“…Many tail-anchored (TA) membrane proteins are targeted to and inserted into the endoplasmic reticulum (ER) by the `guided entry of tail-anchored proteins’…”
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Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer by Altorki, Nasser, Wang, Xiaofei, Kozono, David, Watt, Colleen, Landrenau, Rodney, Wigle, Dennis, Port, Jeffrey, Jones, David R., Conti, Massimo, Ashrafi, Ahmad S., Liberman, Moishe, Yasufuku, Kazuhiro, Yang, Stephen, Mitchell, John D., Pass, Harvey, Keenan, Robert, Bauer, Thomas, Miller, Daniel, Kohman, Leslie J., Stinchcombe, Thomas E., Vokes, Everett

“…In a randomized trial, sublobar resection was noninferior to lobectomy for disease-free survival among patients with peripheral clinical stage T1aN0 (≤2 cm)…”
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Limitations of the Current Standards of Care for Treating Gout and Crystal Deposition in the Primary Care Setting: A Review by Keenan, Robert T., MD, MPH

“…Abstract Purpose This article outlines several important issues regarding the management of patients with gout. The topics discussed include best practices for…”
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Is It Time for Gout Flare Treatment to Move into the 21st Century? by Keenan, Robert T

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A unifying model for membrane protein biogenesis by Hegde, Ramanujan S., Keenan, Robert J.

“…α-Helical integral membrane proteins comprise approximately 25% of the proteome in all organisms. The membrane proteome is highly diverse, varying in the…”
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Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins by Wohlever, Matthew L., Mateja, Agnieszka, McGilvray, Philip T., Day, Kasey J., Keenan, Robert J.

“…Mislocalized tail-anchored (TA) proteins of the outer mitochondrial membrane are cleared by a newly identified quality control pathway involving the conserved…”
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Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum by Anghel, S. Andrei, McGilvray, Philip T., Hegde, Ramanujan S., Keenan, Robert J.

“…Members of the evolutionarily conserved Oxa1/Alb3/YidC family mediate membrane protein biogenesis at the mitochondrial inner membrane, chloroplast thylakoid…”
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Mechanism of an intramembrane chaperone for multipass membrane proteins by Smalinskaitė, Luka, Kim, Min Kyung, Lewis, Aaron J. O., Keenan, Robert J., Hegde, Ramanujan S.

“…Multipass membrane proteins play numerous roles in biology and include receptors, transporters, ion channels and enzymes 1 , 2 . How multipass proteins are…”
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An ER translocon for multi-pass membrane protein biogenesis by McGilvray, Philip T, Anghel, S Andrei, Sundaram, Arunkumar, Zhong, Frank, Trnka, Michael J, Fuller, James R, Hu, Hong, Burlingame, Alma L, Keenan, Robert J

“…Membrane proteins with multiple transmembrane domains play critical roles in cell physiology, but little is known about the machinery coordinating their…”
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A ribosome-associating factor chaperones tail-anchored membrane proteins by Hegde, Ramanujan S, Mariappan, Malaiyalam, Li, Xingzhe, Stefanovic, Sandra, Sharma, Ajay, Mateja, Agnieszka, Keenan, Robert J

“…Hundreds of proteins are inserted post-translationally into the endoplasmic reticulum (ER) membrane by a single carboxy-terminal transmembrane domain (TMD)…”
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The architecture of EMC reveals a path for membrane protein insertion by O'Donnell, John P, Phillips, Ben P, Yagita, Yuichi, Juszkiewicz, Szymon, Wagner, Armin, Malinverni, Duccio, Keenan, Robert J, Miller, Elizabeth A, Hegde, Ramanujan S

“…Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved…”
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Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study) by Bardin, Thomas, Keenan, Robert T, Khanna, Puja P, Kopicko, Jeff, Fung, Maple, Bhakta, Nihar, Adler, Scott, Storgard, Chris, Baumgartner, Scott, So, Alexander

“…Determine the efficacy and safety of daily lesinurad (200 or 400 mg orally) added to allopurinol in patients with serum uric acid (sUA) above target in a…”
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The mechanism of membrane-associated steps in tail-anchored protein insertion by Mariappan, Malaiyalam, Mateja, Agnieszka, Dobosz, Malgorzata, Bove, Elia, Hegde, Ramanujan S., Keenan, Robert J.

“…Tail-anchored (TA) membrane proteins destined for the endoplasmic reticulum are chaperoned by cytosolic targeting factors that deliver them to a membrane…”
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A Randomized, Phase II Study Evaluating the Efficacy and Safety of Anakinra in the Treatment of Gout Flares by Saag, Kenneth G., Khanna, Puja P., Keenan, Robert T., Ohlman, Sven, Osterling Koskinen, Lisa, Sparve, Erik, Åkerblad, Ann‐Charlotte, Wikén, Margareta, So, Alexander, Pillinger, Michael H., Terkeltaub, Robert

“…Objective To evaluate the efficacy and safety of anakinra compared to triamcinolone in the treatment of gout flares. Methods Patients for whom nonsteroidal…”
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The effect of immunomodulators on the efficacy and tolerability of pegloticase: a systematic review by Keenan, Robert T., Botson, John K., Masri, Karim R., Padnick-Silver, Lissa, LaMoreaux, Brian, Albert, John A., Pillinger, Michael H.

“…•Pegloticase is one of the few treatment options for patients with uncontrolled/refractory gout.•Because many patients develop anti-drug antibodies against…”
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