Search Results - "Keenan, K. P."

Assessing biofilm formation by Listeria monocytogenes strains by Harvey, J, Keenan, K.P, Gilmour, A

“…When a microtitre plate assay was used to quantify biofilm production by Listeria monocytogenes strains following growth in Tryptone Soy Broth (TSB) for 48 h…”
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Caloric restriction mimetics: metabolic interventions by Weindruch, R, Keenan, K P, Carney, J M, Fernandes, G, Feuers, R J, Floyd, R A, Halter, J B, Ramsey, J J, Richardson, A, Roth, G S, Spindler, S R

“…Caloric restriction (CR) retards diseases and aging in laboratory rodents and is now being tested in nonhuman primates. One way to apply these findings to…”
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Diet, caloric restriction, and the rodent bioassay by KEENAN, K. P, BALLAM, G. C, SOPER, K. A, LAROQUE, P, COLEMAN, J. B, DIXIT, R

“…The diet can significantly alter the results of toxicity and carcinogenicity studies. Ad libitum (AL) overfeeding of excessive calories to sedentary adult…”
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Chronic Nephropathy in Ad Libitum Overfed Sprague-Dawley Rats and Its Early Attenuation by Increasing Degrees of Dietary (Caloric) Restriction to Control Growth by Keenan, Kevin P., Coleman, John B., Mccoy, Carol L., Hoe, Chao-Min, Soper, Keith A., Laroque, Philippe

“…The early development and progression of chronic nephropathy and its amelioration by moderate and marked dietary restriction (DR) was determined in…”
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The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats by Kemi, Masayuki, Keenan, Kevin P., Mccoy, Carol, Hoe, Chao-Min, Soper, Keith A., Ballam, Gordon C., Van Zwieten, Matthew J.

“…The relative protective effects of modifying dietary protein, fat, fiber, and energy content vs moderate food or dietary restriction (DR) on spontaneous…”
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Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms by Keenan, K P, Soper, K A, Smith, P F, Ballam, G C, Clark, R L

“…This study was designed to compare the effects of ad libitum (AL) overfeeding and moderate dietary restriction (DR) of two different diets on Sprague-Dawley…”
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Society of Toxicologic Pathology Position Paper: Diet as a Variable in Rodent Toxicology and Carcinogenicity Studies by Nold, James B., Keenan, Kevin P., Nyska, Abraham, Cartwright, Mark E.

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Morphological and hormonal changes in the ventral and dorsolateral prostatic lobes of rats treated with finasteride, a 5-Alpha reductase Inhibitor by Prahalada, S., Rhodes, L., Grossman, S.J., Heggan, D., Keenan, K.P., Cukierski, M.A., Hoe, C.M., Berman, C., van Zwieten, M.J.

“…BACKGROUND In rats, the prostate is divided into three distinct lobes, and the lobes are dependent on androgens [testosterone (T) and dihydrotestosterone…”
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Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: II. Effects on age-related proliferative and degenerative lesions by Keenan, K P, Soper, K A, Hertzog, P R, Gumprecht, L A, Smith, P F, Mattson, B A, Ballam, G C, Clark, R L

“…This study compared the effects of ad libitum (AL) overfeeding and moderate dietary restriction (DR) of 2 different diets on Sprague-Dawley (SD) rat survival…”
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BELLE newsletter commentary: does caloric restriction induce hormesis? by Keenan, K P

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Effect of early body weight and moderate dietary restriction on the survival of the sprague-dawley rat by Laroque, P., Keenan, K.P., Soper, K.A., Dorian, C., Gerin, G., Hoe, C-M., Duprat, P.

“…The effects of ad libitum (AL) feeding, moderate dietary restriction (DR), and initial (6-week) and one-year body weights on the two-year survival of the…”
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The early effects of dietary restriction on the pathogenesis of chronic renal disease in Sprague-Dawley rats at 12 months by Gumprecht, L A, Long, C R, Soper, K A, Smith, P F, Haschek-Hock, W M, Keenan, K P

“…This study evaluated the effects of different diets and dietary regimens on the pathogenesis of chronic renal disease (CRD) in Sprague-Dawley rats at 52 wk and…”
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The effects of overfeeding and moderate dietary restriction on Sprague-Dawley rat survival, pathology, carcinogenicity, and the toxicity of pharmaceutical agents by Keenan, K.P., Laroque, P., Soper, K.A., Morrissey, R.E., Dixit, R.

“…Ad libitum (AL) overfeeding is the most significant uncontrolled variable effecting the rodent bioassay. There is a highly significant correlation between food…”
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Morphologic evaluation of the effects of Shiga toxin and E coli Shiga- like toxin on the rabbit intestine by Keenan, KP, Sharpnack, DD, Collins, H, Formal, SB, O'Brien, AD

“…The effects of a Shiga toxin derived from Shigella dysenteriae Type 1, Strain 60R, and a Shiga-like toxin from the enterohemorrhagic Escherichia coli O157:H7,…”
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Effect of food restriction on risk assessment by Keenan, K P

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Induction of emphysema and bronchial mucus cell hyperplasia by intratracheal instillation of lipopolysaccharide in the hamster by Stolk, J, Rudolphus, A, Davies, P, Osinga, D, Dijkman, J H, Agarwal, L, Keenan, K P, Fletcher, D, Kramps, J A

“…The aim of this study was to determine whether lipopolysaccharide-induced elastase release from recruited neutrophils in the hamster lung would induce…”
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Juxtaglomerular cell hypertrophy and hyperplasia induced in rhesus monkeys by angiotensin II receptor antagonists by Owen, R A, Molon-Noblot, S, Hubert, M F, Siegl, P K, Eydelloth, R S, Keenan, K P

“…Juxtaglomerular (JG) cell hypertrophy and hyperplasia were investigated in rhesus monkeys given angiotensin II (AII) AT1 receptor antagonists L-158,338 and DUP…”
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The effects of diet, ad libitum feeding, and moderate and severe dietary restriction on body weight, survival, clinical pathology parameters, and cause of death in control Sprague-Dawley rats by HUBERT, Marie-Francoise, LAROQUE, Philippe, GILLET, Jean-Pierre, KEENAN, Kevin P

“…A 2-year study was conducted in Sprague-Dawley rats to compare the effects of ad libitum (AL) feeding and dietary restriction (DR) on body weight, survival,…”
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Studies of early hepatocellular proliferation and peroxisomal proliferation in Sprague-Dawley rats treated with tumorigenic doses of clofibrate by Tanaka, K, Smith, P F, Stromberg, P C, Eydelloth, R S, Herold, E G, Grossman, S J, Frank, J D, Hertzog, P R, Soper, K A, Keenan, K P

“…Clofibrate, a peroxisome proliferator, is hepatocarcinogenic in rats in a dose-dependent fashion. While there is a relationship between peroxisome…”
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Qualitative and quantitative evaluation of prostatic histomorphology in rats following chronic treatment with finasteride, a 5-alpha reductase inhibitor by Prahalada, S R, Keenan, K P, Hertzog, P R, Gordon, L R, Peter, C P, Soper, K A, van Zwieten, M J, Bokelman, D L

“…To determine any potential direct and/or indirect effects of elevated intraprostatic T levels on the prostates of rats chronically (1-2 years) exposed to high…”
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