Search Results - "Keen, Judith"

The Role of HuR in Gemcitabine Efficacy in Pancreatic Cancer: HuR Up-regulates the Expression of the Gemcitabine Metabolizing Enzyme Deoxycytidine Kinase by COSTANTINO, Christina L, WITKIEWICZ, Agnieszka K, KUWANO, Yuki, COZZITORTO, Joseph A, KENNEDY, Eugene P, DASGUPTA, Abhijit, KEEN, Judith C, YEO, Charles J, GOROSPE, Myriam, BRODY, Jonathan R

“…RNA-binding protein HuR binds U- or AU-rich sequences in the 3'-untranslated regions of target mRNAs, stabilizing them and/or modulating their translation…”
Get full text

Trichostatin A and 5 Aza-2′ deoxycytidine decrease estrogen receptor mRNA stability in ER positive MCF7 cells through modulation of HuR by Pryzbylkowski, Peter, Obajimi, Oluwakemi, Keen, Judith Clancy

“…Trichostatin A (TSA) and 5-Aza 2′deoxycytidine (AZA), two well characterized pharmacologic inhibitors of histone deacetylation and DNA methylation, affect…”
Get full text

Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals by Simon-Sanchez, Javier, Scholz, Sonja, Fung, Hon-Chung, Matarin, Mar, Hernandez, Dena, Gibbs, J. Raphael, Britton, Angela, de Vrieze, Fabienne Wavrant, Peckham, Elizabeth, Gwinn-Hardy, Katrina, Crawley, Anthony, Keen, Judith C., Nash, Josefina, Borgaonkar, Digamber, Hardy, John, Singleton, Andrew

“…The recent hapmap effort has placed focus on the application of genome-wide SNP analysis to assess the contribution of genetic variability, particularly SNPs,…”
Get full text

Responses to the 2017 “1 Million Gray Question”: ASTRO Membership's Opinions on the Most Important Research Question Facing Radiation Oncology by Dominello, Michael M., Keen, Judith C., Beck, Tyler F., Bayouth, John, Knisely, Jonathan, Carlson, David J., Mendonca, Marc S., Mian, Omar, Brock, Kristy K., Anscher, Mitchell, Hugo, Geoffrey, Moros, Eduardo G., Singh, Anurag K., Yu, James B.

Get full text

pp32 (ANP32A) expression inhibits pancreatic cancer cell growth and induces gemcitabine resistance by disrupting HuR binding to mRNAs by Williams, Timothy K, Costantino, Christina L, Bildzukewicz, Nikolai A, Richards, Nathan G, Rittenhouse, David W, Einstein, Lisa, Cozzitorto, Joseph A, Keen, Judith C, Dasgupta, Abhijit, Gorospe, Myriam, Gonye, Gregory E, Yeo, Charles J, Witkiewicz, Agnieszka K, Brody, Jonathan R

“…The expression of protein phosphatase 32 (PP32, ANP32A) is low in poorly differentiated pancreatic cancers and is linked to the levels of HuR (ELAV1), a…”
Get full text

Analysis of the 2017 American Society for Radiation Oncology (ASTRO) Research Portfolio by Yu, James B., Beck, Tyler F., Anscher, Mitchell S., Baschnagel, Andrew M., Brock, Kristy K., Carlson, David J., Dominello, Michael M., Kimple, Randall J., Knisely, Jonathan P., Mendonca, Marc S., Mian, Omar Y., Singh, Anurag K., Moros, Eduardo G., Keen, Judith C.

“…Research in radiation oncology (RO) is imperative to support the discovery of new uses of radiation and improvement of current approaches to radiation delivery…”
Get full text

The ASTRO Research Portfolio: Where Do We Go From Here? by Yu, James B., Beck, Tyler F., Anscher, Mitchell S., Baschnagel, Andrew M., Brock, Kristy K., Carlson, David J., Dominello, Michael M., Kimple, Randall J., Knisely, Jonathan P.S., Mendonca, Marc S., Mian, Omar Y., Singh, Anurag K., Moros, Eduardo G., Keen, Judith C.

Get full text

Assessing the Training and Research Environment for Genomics, Bioinformatics, and Immunology in Radiation Oncology by Mouw, Kent W, Beck, Tyler F, Keen, Judith C, Dicker, Adam P

“…To assess radiation oncologists' perceptions of training and research opportunities in the fields of genomics, bioinformatics, and immunology. A 13-item…”
Get more information

RNA-binding protein HuR regulates GATA3 mRNA stability in human breast cancer cell lines by Licata, Lauren A, Hostetter, Christine L, Crismale, James, Sheth, Anjali, Keen, Judith Clancy

“…Meta-analyses of microarray data indicate that GATA3 is co-expressed with estrogen receptor alpha (ER) in breast cancer cells. While the significance of this…”
Get full text

A step towards a new targeted nanotherapy for pancreatic cancer by Keen, Judith C.

“…Commentary to: Nanoparticulate delivery of diphtheria toxin DNA effectively kills mesothelin expressing pancreatic cancer cells SL Showalter, Y-H Huang, A…”
Get full text

Inhibition of de novo purine synthesis in human prostate cells results in ATP depletion, AMPK activation and induces senescence by Obajimi, Oluwakemi, Keen, Judith Clancy, Melera, Peter W.

“…BACKGROUND 4‐[2‐(2‐Amino‐4‐oxo‐4,6,7,8‐tetrahydro‐3H‐pyrimidino[5,4,6][1,4]thiazin‐6‐yl)‐(S)‐ethyl]‐2,5‐thienoylamino‐l‐glutamic acid (AG2034), is a classical…”
Get full text

Polyamine Analogues Down-regulate Estrogen Receptor α Expression in Human Breast Cancer Cells by Huang, Yi, Keen, Judith C., Pledgie, Allison, Marton, Laurence J., Zhu, Tao, Sukumar, Saraswati, Park, Ben Ho, Blair, Brian, Brenner, Keith, Casero, Robert A., Davidson, Nancy E.

“…The critical role of polyamines in cell growth has led to the development of a number of agents that interfere with polyamine metabolism including a novel…”
Get full text

HuR subcellular distribution changes sensitivity to Tamoxifen in estrogen receptor positive, Tamoxifen resistant breast cancer cells by Licata, Lauren A., MD, Keen, Judith Clancy, PhD, Hostetter, Christine, BA

Get full text

Cytoplasmic accumulation of the RNA binding protein HuR is central to tamoxifen resistance in estrogen receptor positive breast cancer cells by Hostetter, Christine, Licata, Lauren A., Costantino, Christina L., Witkiewicz, Agnes, Yeo, Charles, Brody, Jonathan R, Keen, Judith Clancy

“…With prolonged exposure, a majority of estrogen receptor positive cancers develop resistance to tamoxifen and subsequent therapies including selective estrogen…”
Get full text

Protein phosphatase 2A regulates estrogen receptor alpha (ER) expression through modulation of ER mRNA stability by Keen, Judith C, Zhou, Qun, Park, Ben Ho, Pettit, Catherine, Mack, Kelly M, Blair, Brian, Brenner, Keith, Davidson, Nancy E

“…Protein phosphatase 2A (PP2A) is a ubiquitously expressed member of the serine-threonine phosphatase family that is involved in regulation of many cellular…”
Get full text

The 'RNA-binding ome': future implications for chemotherapeutic efficacy by Brody, Jonathan R, Witkiewicz, Agnieszka K, Yeo, Charles J, Gorospe, Myriam, Keen, Judith C

Get more information

Epigenetic regulation of protein phosphatase 2A (PP2A), Lymphotactin (XCL1) and estrogen receptor alpha (ER) expression in human breast cancer cells by Keen, Judith C., Garrett-Mayer, Elizabeth, Pettit, Catherine, Mack, Kelly M., Manning, Jasper, Herman, James G., Davidson, Nancy E.

“…Absence of the estrogen receptor alpha (ER) in human breast cancer cells is an indicator of poor prognosis, and predictive of lack of response to hormonal…”
Get full text

Physiologic estrogen receptor alpha signaling in non-tumorigenic human mammary epithelial cells by ABUKHDEIR, Abde M, BLAIR, Brian G, VITOLO, Michele I, BACHMAN, Kurtis E, BEN HO PARK, BRENNER, Keith, KARAKAS, Bedri, KONISHI, Hiroyuki, LIM, Joselin, SAHASRANAMAN, Vanita, YI HUANG, KEEN, Judith, DAVIDSON, Nancy

“…Currently, a number of breast cancer cell lines exist that serve as models for both estrogen receptor alpha (ERalpha) positive and ERalpha negative disease…”
Get full text

Characterization of a novel PMA‐inducible pathway of interleukin‐13 gene expression in T cells by Keen, Judith C., Cianferoni, Antonella, Florio, Giovanni, Guo, Jia, Chen, Rongbing, Roman, Jessica, Wills‐Karp, Marsha, Casolaro, Vincenzo, Georas, Steve N.

“…Summary Although interleukin 13 (IL‐13) is an important mediator of asthma and allergic diseases, the molecular mechanisms regulating IL‐13 gene expression are…”
Get full text

Yin-Yang 1 Activates Interleukin-4 Gene Expression in T Cells by Guo, Jia, Casolaro, Vincenzo, Seto, Edward, Yang, Wen-Ming, Chang, Cindy, Seminario, Maria-Cristina, Keen, Judith, Georas, Steve N.

“…Interleukin-4 (IL-4) is a multifunctional cytokine that plays an important role in immune and inflammatory responses. Expression of the IL-4 gene is tightly…”
Get full text