Search Results - "Keely, S. J."

Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis by Reilly, R., Mroz, M. S., Dempsey, E., Wynne, K., Keely, S. J., McKone, E. F., Hiebel, C., Behl, C., Coppinger, J. A.

“…Deletion of phenylalanine 508 of the cystic fibrosis transmembrane conductance regulator (ΔF508 CFTR) is a major cause of cystic fibrosis (CF), one of the most…”
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The bile acid receptor, TGR5, regulates basal and cholinergic‐induced secretory responses in rat colon by Ward, J. B. J., Mroz, M. S., Keely, S. J.

“…Bile acids (BA) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR5, has been…”
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Leptin acts as a mitogenic and antiapoptotic factor for colonic cancer cells by Hoda, M. R., Keely, S. J., Bertelsen, L. S., Junger, W. G., Dharmasena, D., Barrett, K. E.

“…Background: Obesity is associated with increased levels of leptin. The mitogenic actions of leptin have been identified in various cell types. Because obesity…”
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Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects by Barrett, K E, Keely, S J

“…Chloride secretion is the major determinant of mucosal hydration throughout the gastrointestinal tract, and chloride transport is also pivotal in the…”
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Bradykinin regulates human colonic ion transport in vitro by Baird, A W, Skelly, M M, O'Donoghue, D P, Barrett, K E, Keely, S J

“…Background and purpose: Kinins are acknowledged as important regulators of intestinal function during inflammation; however, their effects on human intestinal…”
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Missing link identified: GpBAR1 is a neuronal bile acid receptor by Keely, S. J.

“…In addition to their classical functions in aiding the digestion and absorption of lipids, bile acids are increasingly gaining appreciation for their roles in…”
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MyD88 adaptor-like (Mal) functions in the epithelial barrier and contributes to intestinal integrity via protein kinase C by Corr, S C, Palsson-McDermott, E M, Grishina, I, Barry, S P, Aviello, G, Bernard, N J, Casey, P G, Ward, J B J, Keely, S J, Dandekar, S, Fallon, P G, O'Neill, L A J

“…MyD88 adapter-like (Mal)-deficient mice displayed increased susceptibility to oral but not intraperitoneal infection with Salmonella Typhimurium. Bone marrow…”
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Immune regulation of human colonic electrolyte transport in vitro by Stack, W A, Keely, S J, O'Donoghue, D P, Baird, A W

“…The role of lamina propria cells in regulating human colonic ion transport was investigated in vitro. Normal human colonic mucosae were mounted in Ussing…”
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Insulin and IGF-I inhibit calcium-dependent chloride secretion by T84 human colonic epithelial cells by Chang, N, Uribe, J M, Keely, S J, Calandrella, S, Barrett, K E

“…D-Myo-inositol (3,4,5,6) tetrakisphosphate [Ins(3,4,5,6)P(4)] or phosphatidylinositol 3-kinase (PI 3-kinase) activity acts to inhibit calcium-dependent…”
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Regulation of ion transport by histamine in human colon by Keely, Stephen J., Stack, William A., O'Donoghue, Diarmuid P., Baird, Alan W.

“…Histamine, added to the basolateral side of voltage clamped human colon in vitro, induced a rapid onset, transient inward short circuit current which was…”
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Chronic regulation of colonic epithelial secretory function by activation of G protein‐coupled receptors by Toumi, F., Frankson, M., Ward, J. B., Kelly, O. B., Mroz, M. S., Bertelsen, L. S., Keely, S. J.

“…Background  Enteric neurotransmitters that act at G protein‐coupled receptors (GPCRs) are well known to acutely promote epithelial Cl− and fluid secretion…”
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ErbB2 and ErbB3 Receptors Mediate Inhibition of Calcium-dependent Chloride Secretion in Colonic Epithelial Cells by Keely, Stephen J., Barrett, Kim E.

“…We have previously demonstrated that epidermal growth factor (EGF) inhibits calcium-dependent chloride secretion via a mechanism involving stimulation of…”
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Phosphatidylinositol 3-Kinase Mediates the Inhibitory Effect of Epidermal Growth Factor on Calcium-dependent Chloride Secretion by Uribe, J M, Keely, S J, Traynor-Kaplan, A E, Barrett, K E

“…Epidermal growth factor (EGF) and carbachol both inhibit calcium-activated chloride secretion by the human colonic epithelial cell line, T 84 . Although the…”
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The bile acid receptor, TGR 5, regulates basal and cholinergic‐induced secretory responses in rat colon by Ward, J. B. J., Mroz, M. S., Keely, S. J.

“…Abstract Bile acids ( BA ) are becoming increasingly appreciated as enteric hormones that regulate many aspects of intestinal physiology. The BA receptor, TGR…”
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Carbachol stimulates transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T84 cells. Implications for carbachol-stimulated chloride secretion by Keely, S J, Uribe, J M, Barrett, K E

“…We have examined the role of tyrosine phosphorylation in regulation of calcium-dependent chloride secretion across T84 colonic epithelial cells. The…”
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Chronic regulation of colonic epithelial secretory function by activation of G protein-coupled receptors: Regulation of epithelial secretion by GPCRs by Toumi, F., Frankson, M., Ward, J. B., Kelly, O. B., Mroz, M. S., Bertelsen, L. S., Keely, S. J.

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Regulation of Chloride Secretion: Novel Pathways and Messengers by KEELY, STEPHEN J., BARRETT, KIM E.

“…: The capacity for active chloride secretion, thereby driving the secretion of fluid, is an important property of the intestinal epithelium. Chloride secretion…”
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Transactivation of the Epidermal Growth Factor Receptor in Colonic Epithelial Cells by Carbachol Requires Extracellular Release of Transforming Growth Factor-[alpha] by McCole, D F, Keely, S J, Coffey, R J, Barrett, KE

“…We have shown previously that the muscarinic agonist, carbachol (CCh), transactivates the epidermal growth factor receptor (EGFr) via calmodulin, Pyk-2, and…”
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Carbachol-stimulated transactivation of epidermal growth factor receptor and mitogen-activated protein kinase in T(84) cells is mediated by intracellular Ca2+, PYK-2, and p60(src) by Keely, S J, Calandrella, S O, Barrett, K E

“…Ca(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein kinase…”
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Carbachol-stimulated Transactivation of Epidermal Growth Factor Receptor and Mitogen-activated Protein Kinase in T sub(84) Cells Is Mediated by Intracellular Ca super(2+), PYK-2, and p60 super(src) by Keely, S J, Calandrella, SO, Barrett, KE

“…Ca super(2+)-dependent agonists, such as carbachol (CCh), stimulate epidermal growth factor receptor (EGFR) transactivation and mitogen-activated protein…”
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