Search Results - "Keely, Patricia"

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling by Provenzano, Paolo P, Keely, Patricia J

“…The notion that cell shape and spreading can regulate cell proliferation has evolved over several years, but only recently has this been linked to forces from…”
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Biomechanical Remodeling of the Microenvironment by Stromal Caveolin-1 Favors Tumor Invasion and Metastasis by Goetz, Jacky G., Minguet, Susana, Navarro-Lérida, Inmaculada, Lazcano, Juan José, Samaniego, Rafael, Calvo, Enrique, Tello, Marta, Osteso-Ibáñez, Teresa, Pellinen, Teijo, Echarri, Asier, Cerezo, Ana, Klein-Szanto, Andres J.P., Garcia, Ricardo, Keely, Patricia J., Sánchez-Mateos, Paloma, Cukierman, Edna, Del Pozo, Miguel A.

“…Mechanotransduction is a key determinant of tissue homeostasis and tumor progression. It is driven by intercellular adhesions, cell contractility, and forces…”
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Mechanisms by Which the Extracellular Matrix and Integrin Signaling Act to Regulate the Switch Between Tumor Suppression and Tumor Promotion by Keely, Patricia J.

“…Cell adhesion to the extracellular matrix (ECM) is necessary for development of the mammary gland, and to maintain the normal architecture and function of the…”
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Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression by Schedin, Pepper, Keely, Patricia J

“…Cells of the mammary gland are in intimate contact with other cells and with the extracellular matrix (ECM), both of which provide not only a biochemical…”
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Collagen reorganization at the tumor-stromal interface facilitates local invasion by Provenzano, Paolo P, Eliceiri, Kevin W, Campbell, Jay M, Inman, David R, White, John G, Keely, Patricia J

“…Stromal-epithelial interactions are of particular significance in breast tissue as misregulation of these interactions can promote tumorigenesis and invasion…”
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3D Collagen Alignment Limits Protrusions to Enhance Breast Cancer Cell Persistence by Riching, Kristin M., Cox, Benjamin L., Salick, Max R., Pehlke, Carolyn, Riching, Andrew S., Ponik, Susan M., Bass, Benjamin R., Crone, Wendy C., Jiang, Yi, Weaver, Alissa M., Eliceiri, Kevin W., Keely, Patricia J.

“…Patients with mammographically dense breast tissue have a greatly increased risk of developing breast cancer. Dense breast tissue contains more stromal…”
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The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis by Zhang, Kun, Corsa, Callie A., Ponik, Suzanne M., Prior, Julie L., Piwnica-Worms, David, Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

“…Increased stromal collagen deposition in human breast tumours correlates with metastases. We show that activation of the collagen I receptor DDR2 (discoidin…”
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A three-dimensional computational model of collagen network mechanics by Lee, Byoungkoo, Zhou, Xin, Riching, Kristin, Eliceiri, Kevin W, Keely, Patricia J, Guelcher, Scott A, Weaver, Alissa M, Jiang, Yi

“…Extracellular matrix (ECM) strongly influences cellular behaviors, including cell proliferation, adhesion, and particularly migration. In cancer, the rigidity…”
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Phenotypic heterogeneity of disseminated tumour cells is preset by primary tumour hypoxic microenvironments by Fluegen, Georg, Avivar-Valderas, Alvaro, Wang, Yarong, Padgen, Michael R., Williams, James K., Nobre, Ana Rita, Calvo, Veronica, Cheung, Julie F., Bravo-Cordero, Jose Javier, Entenberg, David, Castracane, James, Verkhusha, Vladislav, Keely, Patricia J., Condeelis, John, Aguirre-Ghiso, Julio A.

“…Hypoxia is a poor-prognosis microenvironmental hallmark of solid tumours, but it is unclear how it influences the fate of disseminated tumour cells (DTCs) in…”
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Why the stroma matters in breast cancer: Insights into breast cancer patient outcomes through the examination of stromal biomarkers by Conklin, Matthew W., Keely, Patricia J.

“…Survival and recurrence rates in breast cancer are variable for common diagnoses, and therefore the biological underpinnings of the disease that determine…”
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Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2 by Lyons, Traci R, O'Brien, Jenean, Borges, Virginia F, Conklin, Matthew W, Keely, Patricia J, Eliceiri, Kevin W, Marusyk, Andriy, Tan, Aik-Choon, Schedin, Pepper

“…Postpartum involution of the mammary gland is a recognized risk factor for breast cancer. This report identifies a mechanism that could be at least partially…”
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Mechano-Signal Transduction in Mesenchymal Stem Cells Induces Prosaposin Secretion to Drive the Proliferation of Breast Cancer Cells by Ishihara, Seiichiro, Inman, David R, Li, Wan-Ju, Ponik, Suzanne M, Keely, Patricia J

“…In response to chemical stimuli from cancer cells, mesenchymal stem cells (MSC) can differentiate into cancer-associated fibroblasts (CAF) and promote tumor…”
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Aligned Collagen Is a Prognostic Signature for Survival in Human Breast Carcinoma by Conklin, Matthew W, Eickhoff, Jens C, Riching, Kristin M, Pehlke, Carolyn A, Eliceiri, Kevin W, Provenzano, Paolo P, Friedl, Andreas, Keely, Patricia J

“…Evidence for the potent influence of stromal organization and function on invasion and metastasis of breast tumors is ever growing. We have performed a…”
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Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer by Bredfeldt, Jeremy S, Liu, Yuming, Pehlke, Carolyn A, Conklin, Matthew W, Szulczewski, Joseph M, Inman, David R, Keely, Patricia J, Nowak, Robert D, Mackie, Thomas R, Eliceiri, Kevin W

“…Second-harmonic generation (SHG) imaging can help reveal interactions between collagen fibers and cancer cells. Quantitative analysis of SHG images of collagen…”
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COX-2 modulates mammary tumor progression in response to collagen density by Esbona, Karla, Inman, David, Saha, Sandeep, Jeffery, Justin, Schedin, Pepper, Wilke, Lee, Keely, Patricia

“…High breast density is linked to an increased risk of breast cancer, and correlates with changes in collagen. In a mouse model of mammary carcinoma in the…”
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Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells by Barcus, Craig E, Holt, Elizabeth C, Keely, Patricia J, Eliceiri, Kevin W, Schuler, Linda A

“…Breast cancers that express estrogen receptor alpha (ERα+) constitute the majority of breast tumors. Estrogen is a major driver of their growth, and targeting…”
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Contact Guidance Mediated Three-Dimensional Cell Migration is Regulated by Rho/ROCK-Dependent Matrix Reorganization by Provenzano, Paolo P., Inman, David R., Eliceiri, Kevin W., Trier, Steven M., Keely, Patricia J.

“…Cells generate mechanical force to organize the extracellular matrix (ECM) and drive important developmental and reparative processes. Likewise, tumor cells…”
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Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217 by Northey, Jason J, Barrett, Alexander S, Acerbi, Irene, Hayward, Mary-Kate, Talamantes, Stephanie, Dean, Ivory S, Mouw, Janna K, Ponik, Suzanne M, Lakins, Jonathon N, Huang, Po-Jui, Wu, Junmin, Shi, Quanming, Samson, Susan, Keely, Patricia J, Mukhtar, Rita A, Liphardt, Jan T, Shepherd, John A, Hwang, E Shelley, Chen, Yunn-Yi, Hansen, Kirk C, Littlepage, Laurie E, Weaver, Valerie M

“…Women with dense breasts have an increased lifetime risk of malignancy that has been attributed to a higher epithelial density. Quantitative proteomics,…”
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Stiff Collagen Matrices Increase Tumorigenic Prolactin Signaling in Breast Cancer Cells by Barcus, Craig E., Keely, Patricia J., Eliceiri, Kevin W., Schuler, Linda A.

“…Clinically, circulating prolactin levels and density of the extracellular matrix (ECM) are individual risk factors for breast cancer. As tumors develop, the…”
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The Action of Discoidin Domain Receptor 2 in Basal Tumor Cells and Stromal Cancer-Associated Fibroblasts Is Critical for Breast Cancer Metastasis by Corsa, Callie A.S., Brenot, Audrey, Grither, Whitney R., Van Hove, Samantha, Loza, Andrew J., Zhang, Kun, Ponik, Suzanne M., Liu, Yuming, DeNardo, David G., Eliceiri, Kevin W., Keely, Patricia J., Longmore, Gregory D.

“…High levels of collagen deposition in human and mouse breast tumors are associated with poor outcome due to increased local invasion and distant metastases…”
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